A5008642221- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Vaccine Coverage and Hesitancy
- Syphilis Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Food Security and Health in Diverse Populations
- Diet, Metabolism, and Disease
- Sex work and related issues
South African Medical Research Council
2018-2025
University of KwaZulu-Natal
2015
There is limited information on SARS-CoV-2 seroprevalence among children and adolescents in LMIC school settings. We aimed to assess (1) the of antibodies, (2) prevalence self-reported or confirmed prior infections and, (3) COVID-19 symptoms (including long-COVID) a cohort primary learners, their parents teachers semi-rural setting approximately 3-years into pandemic. Learners grades 1-7 attending two pre-selected schools close proximity Ndwedwe area, iLembe district, KwaZulu-Natal, South...
In addition to being the epicentre of HIV epidemic, South Africa also has highest burden sexually transmitted infections (STIs) in world. Therefore, understanding most influential risk factors STIs is a research priority. Using data from 9948 women who resided KwaZulu Natal, Africa, we estimated population attributable quantify combined impacts on STI diagnosis. Overall prevalence was 20%, and incidence 15 per 100 person-years. Four factors: age at sexual debut, single/not cohabiting, two or...
South Africa has the highest burden of human immunodeficiency virus (HIV) infections in world with significant geographical variations. We identified predictors HIV and their sub-geographical-level contributions to epidemic using a decade long data (2002–2012) from 6484 African women. Generalized additive models were used uncover most features these estimates across region. In overall analysis, younger age, not married or cohabiting partner, partner another partner(s) null/prim parity,...
The ambitious goal to eliminate new pediatric HIV infections by 2030 requires accelerated prevention strategies in high-risk settings such as South Africa. One approach could be pre-exposure prophylaxis (PrEP) with broadly neutralizing anti-HIV-1 monoclonal antibodies (bNAbs). aim of our study is define the optimal dose(s), ideal combination(s) bNAbs terms potency and breadth, timing subcutaneous (SC) administration(s) prevent breast milk transmission HIV. Two bNAbs, CAP256V2LS VRC07-523LS,...
Background In low- and middle-income countries (LMICs) such as South Africa, there is paucity of data on SARS-CoV-2 infections among children attending school, including seroprevalence transmission dynamics. Objective This pilot study aims to assess (1) the prevalence self-reported or confirmed prior infections, COVID-19 symptoms (including long COVID), antibodies, general/mental health, (2) longitudinal changes in seroprevalence, (3) acute immune responses, dynamics, symptomatic versus...
<h3>Background</h3> Breastmilk optimizes child survival in low-middle income high HIV prevalence settings. However, breastmilk transmission of HIV-1 continues to contribute residual vertical transmission. The Phase 1 PedMAb clinical trial aims define the optimal doses, ideal combination and timing subcutaneous (SC) administration two broadly neutralizing antibodies (bNAbs), VRC07-523LS CAP256V2LS, separately or combination, prevent incidence regions such as South Africa. is being conducted...
Abstract Background Women enrolled in human immunodeficiency virus (HIV) prevention efficacy trials receive counseling on of HIV, sexually transmitted infections (STIs), and pregnancy during every visit. Incident has an impact outcomes. Incidence rates HIV/STIs among women who became pregnant associated risk factors were assessed. Methods Data from 9165 participating HIV KwaZulu-Natal, South Africa 2002–2012 combined. Demographic behavioral predictors incidence STIs determined using Cox...
Abstract Background Elimination of vertical HIV Transmission (VHT) and maternal deaths are global health priorities. Male involvement is one the most important factors that influences women’s decisions, including uptake Prevention transmission (P-VHT). We sought to understand not knowing a male partner’s status (MPHIVs) amongst women using services prevent in six South African districts with high antenatal burden. Methods A mixed-methods cross-sectional study was conducted districts, data...
South Africa is faced with a high HIV and STI prevalence incidence, respectively, pockets of burden areas driving these diseases. Localised monitoring the epidemic endemic would enable more effective targeted prevention strategies. We assessed spatial variations in curable incidence among cohort women enrolled clinical trials between 2002 2012. rates from 7557 African five were geo-mapped using participant household GPS coordinates. Age period standardised calculated for 43 recruitment...
<title>Abstract</title> <bold>Background:</bold> The ambitious goal to eliminate new pediatric HIV infections by 2030 requires accelerated prevention strategies in high-risk settings such as South Africa. One approach could be pre-exposure prophylaxis (PrEP) with broadly neutralizing anti-HIV-1 monoclonal antibodies (bNAbs). aim of our study is define the optimal dose(s), ideal combination(s) bNAbs terms potency and breadth, timing subcutaneous (SC) administration(s) prevent breast milk...
<sec> <title>BACKGROUND</title> In low-middle income countries (LMIC), such as South Africa, there is paucity of data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections amongst children attending school, including seroprevalence and transmission dynamics. </sec> <title>OBJECTIVE</title> This pilot study aims to assess (i) the prevalence self-reported or confirmed SARS-CoV-2 prior infections, COVID-19 symptoms (including long-COVID), antibodies general/mental-health...