A5020999058- Gut microbiota and health
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Bacillus and Francisella bacterial research
- Animal Disease Management and Epidemiology
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal motility and disorders
- T-cell and B-cell Immunology
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Exercise and Physiological Responses
- Zoonotic diseases and public health
- Effects and risks of endocrine disrupting chemicals
- Tryptophan and brain disorders
- Digestive system and related health
- Microscopic Colitis
- Veterinary Equine Medical Research
- Food Supply Chain Traceability
- Cannabis and Cannabinoid Research
- Osteoarthritis Treatment and Mechanisms
- Galectins and Cancer Biology
Texas A&M University
2016-2024
Bryan College
2022
Texas A&M Health Science Center
2016-2019
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used classes medications in world. Unfortunately, NSAIDs induce an enteropathy associated with high morbidity and mortality. Although pathophysiology this condition involves interaction gut epithelium, microbiota, NSAIDs, precise mechanisms by which microbiota influence NSAID unclear. One possible mechanism is that may attenuate severity disease specific metabolite-mediated regulation host inflammation injury. The...
Several previous studies have pointed to environmental chemical exposure during windows of development as a contributing factor in neurodevelopmental disorders and correlated these with microbiota dysbiosis; however, little is known about how the chemicals specifically alter interfere development. The findings reported this paper unambiguously establish that pollutant linked can directly modify promote production potentially toxic metabolite ( p -cresol) has also been disorders. Furthermore,...
Osteoarthritis (OA) is a prevalent and economically costly source of lameness in the athletic horse. Previous studies investigating OA pathology have focused on localized trauma to articular cartilage joint, largely ignoring systemic immune status animal. In this study, yearling Quarter Horses were used evaluate cytokine gene expression circulating leukocytes following intra-articular inflammatory insult endotoxin, lipopolysaccharide (LPS). Treatments for 35-d experiment included an...
Immunotherapy has led to impressive advances in the treatment of autoimmune and pro-inflammatory disorders; yet, its clinical outcomes remain limited by a variety factors including microenvironment (IME). Discovering effective immunomodulatory agents, mechanisms which they control disease, will lead innovative strategies for enhancing effectiveness current immunotherapeutic approaches. We have metabolically engineered an attenuated bacterial strain (i.e., Brucella melitensis 16M ∆vjbR,...
Abstract Autophagy is an evolutionarily conserved cellular mechanism that crucial for promoting cell survival, pathogen clearance, and homeostasis. Dysregulated autophagy destabilizes GI tract homeostasis, promotes Crohn’s Disease, perturbs the microbiota, a prominent feature during gut inflammation. Classically, energy substrate starvation induces autophagy, yet host dietary intake makes nutritionally abundant. Thus, discrete signals able to induce overcome cues from fully replete...
The Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N) convened an "Applied Biorisk Biosafety Gap Assessment Workshop" held February 9-10, 2023, in Baltimore, Maryland. As the global prevalence, complexity, severity of infectious transboundary veterinary diseases emerging zoonotic are increasing, there is growing recognition concern that biorisk management data required to understand counter these threats lacking. With sponsorship from U.S. Department Agriculture...
Abstract A significant hallmark of the chronic inflammatory disease, atherosclerosis, is accumulation pro-inflammatory M1-like macrophages (macs) and dendritic cells (DCs) in coronary arteries that respond to pro-atherogenic stimuli fail digest lipids contribute formation foam atherosclerotic plaques. Mechanisms reduce Mac/DC inflammation, increase lipid degradation, prevent cell are likely decrease progression atherosclerosis. regulate autophagy macs DCs will reveal targets for prevention...
Abstract Exposure to environmental chemicals during windows of development is a potentially contributing factor in gut microbiota dysbiosis, and linked chronic diseases developmental disorders. We used community-level model metabolism investigate the effects diethylhexyl phthalate (DEHP), ubiquitous plasticizer implicated neurodevelopmental disorders, on composition metabolite outputs young mice. Administration DEHP by oral gavage increased abundance Lachnoclostridum , while decreasing...
Abstract Immunotherapy has led to impressive advances in the treatment of autoimmune and pro-inflammatory disorders; yet, its clinical outcomes remain limited by a variety factors including microenvironment (IME). Discovering effective immunomodulatory agents, mechanisms which they control disease, will lead innovative strategies for enhancing effectiveness current immunotherapeutic approaches. We have metabolically engineered an attenuated bacterial strain (i.e., Brucella melitensis 16M Δ...