A5069087753- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Peripheral Artery Disease Management
- Pressure Ulcer Prevention and Management
- Diagnosis and Treatment of Venous Diseases
- Skin Diseases and Diabetes
- Retinal Diseases and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Retinal Development and Disorders
- Thyroid Cancer Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Bone and Joint Diseases
- Pain Mechanisms and Treatments
- Orthopedic Infections and Treatments
- Retinal Imaging and Analysis
- Pain Management and Treatment
- Streptococcal Infections and Treatments
- Angiogenesis and VEGF in Cancer
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Acute Ischemic Stroke Management
- Thyroid and Parathyroid Surgery
- Lower Extremity Biomechanics and Pathologies
- Hematological disorders and diagnostics
- Protease and Inhibitor Mechanisms
University of Rome Tor Vergata
2016-2025
CTO Hospital
2023-2025
CTO Andrea Alesini
2022-2025
Policlinico Tor Vergata
2012-2024
ASL Roma
2024
Policlinico Abano Terme
2019
Istituti di Ricovero e Cura a Carattere Scientifico
1997-2012
Istituto Superiore di Sanità
2008
Beth Israel Deaconess Medical Center
2003
Centro San Giovanni di Dio Fatebenefratelli
1997
Outcome data on individuals with diabetic foot ulcers are scarce, especially in those peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome a large population of ulcer patients and whether such predictors differ between without PAD.Analyses were conducted within EURODIALE Study, prospective cohort study 1,088 across 14 centres Europe. Multiple logistic regression modelling was used to identify independent (i.e. non-healing...
The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners. Now considered an inflammatory syndrome, characterized by varying degrees bone joint disorganization secondary underlying neuropathy, trauma, perturbations metabolism. An international task force experts was convened American Diabetes Association Podiatric...
The aim of the present study was to investigate resource utilisation and associated costs in patients with diabetic foot ulcers analyse differences between individuals or without peripheral arterial disease (PAD) and/or infection.Data on were collected prospectively a European multicentre study. Data 1,088 available for analysis use, data 821 included costing analysis. Costs calculated each patient by multiplying country-specific direct indirect unit number resources used from inclusion into...
Critical appraisal of secondary data made available by the OECD for time frame 2000-2011.Comparison trends and variation amputations in people with diabetes across countries. Generalized estimating equations to test statistical significance annual change adjusting major potential confounders.A total 26 countries contributed collection at least 1 year reference frame, showing a decline rates over 40 %, from mean 13.2 (median 9.4, range 5.1-28.1) 7.8 per 100,000 general population (9.9,...
Infection commonly complicates diabetic foot ulcers and is associated with a poor outcome. In cohort of individuals an infected ulcer, we aimed to determine independent predictors lower-extremity amputation the predictive value for International Working Group on Diabetic Foot (IWGDF) classification system develop risk score predicting amputation.We prospectively studied 575 patients ulcer presenting 1 14 clinics in 10 European countries.Among these patients, 159 (28%) underwent amputation....
OBJECTIVE To evaluate the efficacy of manufactured shoes specially designed for diabetic patients (Podiabetes by Buratto Italy) to prevent relapses foot ulcerations. RESEARCH DESIGN AND METHODS A prospective multicenter randomized follow-up study with previous ulcerations was conducted. Patients were alternatively assigned wear either their own (control group, C; n = 36) or therapeutic P; 33). The number ulcer recorded during 1-year follow-up. RESULTS Both C and P groups had similar risk...
To determine current management and to identify patient-related factors barriers that influence strategies in diabetic foot disease.The Eurodiale Study is a prospective cohort study of 1232 consecutive individuals presenting with new ulcer 14 centres across Europe. We determined the use strategies: referral, offloading, vascular imaging revascularization.Twenty-seven percent patients had been treated for > 3 months before referral clinic. This varied considerably between countries (6-55%)....
Diabet. Med. 28, 199–205 (2011) Abstract Objectives The incidence of minor amputation may vary significantly, and determinants have not been studied systematically. We evaluated rate, the differences in rate between European centres. Methods In Eurodiale study, a prospective cohort study 1232 patients (1088 followed until end‐point) with new diabetic foot ulcer were on monthly basis healing, death, major or up to maximum 1 year. Ulcers treated according international guidelines. Baseline...
OBJECTIVE We describe the long-term outcomes of 510 diabetic patients with critical limb ischemia (CLI) and an active foot ulcer or gangrene, seen at University Hospital Rome Tor Vergata, a tertiary care clinic. RESEARCH DESIGN AND METHODS These were between November 2002 2007 (mean follow-up 20 ± 13 months [range 1–66 months]). The Texas Wound Classification was used to grade these wounds that either class C (ischemia) D (ischemia+infection) 2–3 (deep–very deep). This comprehensive...
Abstract Aim To identify the factors responsible for low health‐related quality of life associated with foot ulcers and relative importance these factors. Methods A total 1232 patients a new ulcer, who presented at one 14 centres in 10 European countries participating Eurodiale study, were included this cross‐sectional study. Patient ulcer characteristics obtained as well results from Euro‐Qol‐5D questionnaire, instrument five domains (mobility, self‐care, usual activities, pain/discomfort...
This study aims to evaluate clinical and ulcer characteristics as well the outcomes of patients with diabetic foot ulcers (DFUs). The group was composed DFUs managed by a limb salvage protocol according guidance. Clinical findings were described, 1-year defined salvage, healing, healing time, major amputation death compared between neuropathic ischemic DFUs. One thousand, one hundred ninety-eight subjects included; 386 (32.2%) 812 (67.8%) Neuropathic younger (69.5 ± 11.5 vs. 74.5 11.5, p...
Our aim was to evaluate the role of SPECT/CT for diagnosis diabetic foot infection by labeled leukocytes.Seventeen patients with 19 clinically suspected sites were included. After leukocyte labeling and administration, planar scans acquired at 30 min, 4 h, 24 h 18 consecutive patients. obtained 6 h. The final established clinical follow-up (24 mo) in all cases bone biopsy 14 sites.Leukocyte scanning positive 16 lesions negative 3. changed interpretation SPECT images 10 (52.6%): it excluded...
Diabetic foot (DF) is a chronic and highly disabling complication of diabetes. The prevalence peripheral arterial disease (PAD) high in diabetic patients and, associated or not with neuropathy (PN), can be found 50% cases DF. It worth pointing out that the number major amputations still very high. Many PAD are revascularised due to lack technical expertise or, even worse, negative beliefs because poor experience. This despite progress obtained techniques distal revascularisation nowadays...
OBJECTIVE Low health-related quality of life (HRQoL) has been consistently reported to be associated with poor prognosis for a variety health outcomes in various settings. We aimed evaluate whether HRQoL patients presenting new diabetic foot ulcers (DFUs) prognostic significance ulcer healing, major amputation, and death. RESEARCH DESIGN AND METHODS followed 1,088 DFUs treatment at one the 14 centers 10 European countries participating Eurodiale (European Study Group on Diabetes Lower...
AimTo define the outcomes of persons with diabetes and foot ulcers (DFUs) managed through a specific triage pathway during COVID-19 crisis.MethodsPatients who had an active DFU emergency were included. All participants using system driven both by ulcer'severity concomitant co-diseases. Subjects severely complicated DFUs urgently referred to hospital regardless comorbidities. received outpatient evaluation (within 48–72 h) admitted if required (revascularization, surgical intervention,...