A5025607929- Mass Spectrometry Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- thermodynamics and calorimetric analyses
- Microfluidic and Capillary Electrophoresis Applications
- Toxic Organic Pollutants Impact
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Chromatography
- Water Treatment and Disinfection
- Ion-surface interactions and analysis
- Environmental remediation with nanomaterials
- Analytical chemistry methods development
- Spectroscopy and Chemometric Analyses
- Metabolomics and Mass Spectrometry Studies
- Microplastics and Plastic Pollution
- Recycling and Waste Management Techniques
Imperial College London
2016-2022
National Physical Laboratory
2016-2022
Laboratoire Sols et Environnement
2013-2015
Departement Gesundheit und Soziales
2014
A new, more robust sprayer for desorption electrospray ionization (DESI) mass spectrometry imaging is presented. The main source of variability in DESI thought to be the uncontrolled various geometric parameters sprayer, primarily position solvent capillary, or specifically, its positioning within gas capillary nozzle. If off-center, becomes asymmetrical, making geometry difficult control and compromising reproducibility. stiffness, tip quality, are improved, reproducibility can improved by...
Analyzing lipid composition and distribution within the brain is important to study white matter pathologies that present focal demyelination lesions, such as multiple sclerosis. Some lesions can endogenously re-form myelin sheaths. Therapies aim enhance this repair process in order reduce neurodegeneration disability progression patients. In context, a lipidomic analysis providing both precise molecular classification well-defined localization crucial detect changes content. Here we develop...
In this study, we examine the suitability of desorption electro-flow focusing ionization (DEFFI) for mass spectrometry imaging (MSI) biological tissue. We also compare performance electrospray (DESI) with and without flow setup. The main potential advantages applying mechanism in DESI is its rotationally symmetric jet, higher intensity, more controllable parameters, better portability due to robustness sprayer. parameters DEFFI have therefore been thoroughly optimized, primarily spatial...
In this study, the impact of sprayer design and geometry on performance in desorption electrospray ionization mass spectrometry (DESI-MS) is assessed, as thought to be a major source variability. Absolute intensity repeatability, spectral composition, classification accuracy for biological tissues are considered. Marked differences tissue analysis seen between commercially available lab-built sprayer. These associated with solvent capillary resulting shape primary electrospray. Experiments...
Options were explored for fulfilling the legally required safety assessment a widely applied epoxy/amine coating used restoring corroded domestic drinking water supply systems. The was made up of two components mixed shortly before application, first mainly consisting bisphenol A diglycidyl ether (BADGE), second various amines. analytically identified starting substances all authorised, but only constituted small proportion low molecular mass material left after curing and potentially...