A5008399319- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Practices
- Asthma and respiratory diseases
- Economic and Financial Impacts of Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS Research and Interventions
- Bacterial Infections and Vaccines
- Renal cell carcinoma treatment
- Meta-analysis and systematic reviews
- Respiratory and Cough-Related Research
- Chronic Disease Management Strategies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- HIV Research and Treatment
- Statistical Methods in Clinical Trials
- Hepatitis Viruses Studies and Epidemiology
- Healthcare Policy and Management
- Multiple and Secondary Primary Cancers
- Ovarian cancer diagnosis and treatment
- Diabetes Treatment and Management
- Vaccine Coverage and Hesitancy
GlaxoSmithKline (France)
2010-2024
GlaxoSmithKline (United Kingdom)
2019-2021
Bristol-Myers Squibb (France)
2021
GlaxoSmithKline (India)
2021
French Norwegian Foundation
2020
Abstract A potentially traumatic event (PTE) contributes to trauma through its frequency, conditional probability of posttraumatic stress disorder (PTSD), and experience other PTEs. cross‐sectional survey was conducted, enrolling 21,425 adults nationally representative six European countries. Using the WHO‐Composite International Diagnostic Interview, 8,797 were interviewed on 28 PTEs PTSD. Prevalence 12‐month PTSD 1.1%. When present, mean number experienced 3.2. In a multivariate analysis...
Vaccination of at-risk populations against Neisseria meningitidis is an important strategy to prevent invasive meningococcal disease (IMD). The objective this study was characterize preexisting risk factors in patients with IMD and compare their relative importance. This case-control analysis performed the French national public health insurance database (SNDS). Cases consisted all people hospitalized for France over a six-year period (2012–2017). Controls were matched by age, gender,...
Objectives A novel long-acting regimen (LAR) of cabotegravir and rilpivirine for HIV treatment requires dosing every 2 months instead daily. We assessed what proportion people living with physicians would be interested in trying offering LAR respectively why. Methods 688 on treatment, 120 completed web-based surveys Germany, Italy, the UK France during 2019. Balanced description a hypothetical regarding efficacy, administration possible side effects were provided. The injections assumed to...
This clinical trial assessed whether a potent, selective GPR109A agonist, GSK256073, could, through inhibition of lipolysis, acutely improve glucose homeostasis in subjects with type 2 diabetes mellitus.Thirty-nine diabetic were enrolled the randomized, single-blind, placebo-controlled, three-period crossover trial. Each subject received placebo and two four regimens GSK256073 for days. was dosed 5 mg every 12 h before breakfast supper (BID), 10 24 (QD), 25 BID 50 QD.The change from baseline...
Invasive meningococcal disease (IMD) is an uncommon but serious infectious disease. Its economic burden known to be high poorly characterised. The objective of this study was determine costs, as captured in the healthcare claims database, incurred by all patients hospitalised for IMD France over a 6-year period.This case-control performed using French national public health insurance database (SNDS). Cases comprised individuals with acute between 2012 and 2017 inclusive. For each case, three...
Patient characteristics and survival outcomes in randomized trials may be different from those real-life clinical practice. The objective of this study was to describe treatment pathways, safety, drug costs patients with metastatic Renal Cell Carcinoma (mRCC) a real world setting. A retrospective analysis performed using IQVIA oncology cross-sectional survey data, database collecting anonymized patient-level data Europe. Data on naïve mRCC who received first-line targeted therapy France were...
Background: Increasing availability of therapeutic options for COPD may drive new treatment pathways. This study describes in France, focusing on identifying initial modifications patients with who either initiated long-acting bronchodilator (LABD)-based therapy or escalated to triple (long-acting muscarinic antagonist [LAMA] + β 2 -agonist [LABA] inhaled corticosteroid [ICS]). Methods: retrospective analysis a large general practitioner database (IQVIA Longitudinal Patient Database) France...
The aim of this study was to assess the economic burden hospitalisations for metastatic renal cell carcinoma (mRCC), describe patterns prescribing expensive drugs and explore impact geographic socio-demographic factors on use these drugs.We performed a retrospective analysis from French national hospitals database. Hospital stays mRCC between 2008 2013 were identified by combining 10th revision International Classification Diseases (ICD-10) codes (C64) metastases (C77 C79). Incident cases...
Objectives: The objective of this study was to describe treatment patterns, survival, healthcare use and costs in patients with metastatic renal cell carcinoma (mRCC) a real-world setting.Research design methods: We used the National Health Insurance (NHI) claims database for Ile-de-France region perform retrospective cohort analysis mRCC treated by first-line targeted therapy. Treatment naïve were identified combining 10th revision International Classification Diseases (ICD-10) codes (C64 &...
Background & aims Pulmonary arterial hypertension is a severe disease associated with frequent hospitalisations. This retrospective analysis of the French medical information PMSI-MSO database aimed to describe incident cases patients pulmonary hospitalised in France 2013 and document hospitalisation costs from national health insurance perspective. Methods Cases were identified using diagnostic algorithm. All no previous two years retained. hospital stays during year following index...
Abstract Background The daily oral dosing requirement for antiretroviral therapy (ART) may be challenging some people living with HIV (PLWHIV) comorbid conditions, confidentiality concerns or pill fatigue. We investigated suboptimal adherence from the perspective of PLWHIV and physicians. Methods on ART (n = 688) physicians 120) were surveyed during 2019 in France, Germany, Italy UK. Suboptimal was a report participant missed taking their dose as prescribed ‘Sometimes’/‘Often’/‘Very often’....
Quantitative benefit-risk models (qBRm) applied to vaccines are increasingly used by public health authorities and pharmaceutical companies as an important tool help decision makers with supporting assessment (BRA). However, many publications on vaccine qBRm provide insufficient details the methodological approaches used. Incomplete and/or inadequate reporting may affect result interpretation confidence in BRA, highlighting a need for development of standard guidance.Our objective was...
Invasive meningococcal disease (IMD) carries a high burden in terms of mortality, long-term complications, and cost, which can be significantly reduced by vaccination. The objectives this case-control study were to document the care pathways patients with IMD before, during, after hospitalization assess in-hospital complications sequelae. Cases consisted all people hospitalized for France between 2012 2017. Controls matched age, gender, district residence. Data extracted from French national...
Current asthma guidelines recommend use of inhaled corticosteroids (ICS) in patients with persistent disease. This study was designed to investigate (1) the proportion prescribed ICS-containing maintenance treatment who achieve control, (2) determinants control and (3) how physicians adapt level control.General practitioners (GPs) chest (CPs) France recruited consulting for an ICS. Over a 2-year follow-up period, symptoms previous 3 months treatments were documented at each visit. Variables...