A5102770377- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Hedgehog Signaling Pathway Studies
- Cancer Mechanisms and Therapy
- Cervical and Thoracic Myelopathy
- Dendrimers and Hyperbranched Polymers
- Liver physiology and pathology
- Bone Tumor Diagnosis and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protease and Inhibitor Mechanisms
- Connective Tissue Growth Factor Research
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Proteoglycans and glycosaminoglycans research
- Biomarkers in Disease Mechanisms
- Piperaceae Chemical and Biological Studies
- Amino Acid Enzymes and Metabolism
- Receptor Mechanisms and Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemokine receptors and signaling
Xi'an Medical University
2013-2023
Center for Cancer Research
2022
Beijing Friendship Hospital
2022
Xi'an Jiaotong University
2011-2012
First Affiliated Hospital of Xi'an Jiaotong University
2009-2011
First Hospital of Xi'an
2009
Combination chemotherapy has been proven to be an efficient strategy for the treatment of prostate cancer (PCA). However, pharmacokinetic distinction between drugs is insurmountable barrier realization their synergistic use against cancer. To overcome disadvantages combination in PCA, targeted nanoparticles (NPs), which can codeliver docetaxel (DOC) and doxorubicin (DOX) at optimal proportions, have designed. The DOC DOX codelivery (DDC NPs) were constructed by hyaluronic acid (HA) cationic...
Background: Combination chemotherapy plays an important role in the clinical therapy of non-small cell lung cancer (NSCLC).However, pharmacokinetic differences between drugs are insurmountable barrier traditional treatment.For synergistic NSCLC, nanoparticles (EDS NPs) loaded with both EGFR inhibitor and doxorubicin (DOX) were designed prepared.Methods: Erlotinib, apatinib icotinib evaluated for optimal combination DOX treatment NSCLC via CCK-8 assay.Then cationic amphipathic starch (CSaSt)...
Objective: The long-noncoding RNAs (lncRNAs) have been identified as key players in diverse cellular processes non-small cell lung cancer (NSCLC). However, the understanding of biological functions and detailed mechanisms lncRNAs is still limited. Herein, lncRNA susceptibility candidate 9 (CASC9) on NSCLC progression investigated. Materials Methods: Expressions CASC9, HuR division cycle 6 (CDC6) tissues were detected with quantitative real-time polymerase chain reaction (qRT-PCR). counting...
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which transcriptionally activated c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid derivatives were identified as DFMO adjunct agents. Further studies far upstream binding protein 1 (FUBP1) target of lead compound 9. FUBP1 a single-stranded DNA/RNA and master controller specific genes including c-Myc p21. We showed 9 does not inhibit...
Fibronectin and CD44v6 are involved in tumor invasion metastasis. We examined fibronectin expression normal liver cancer by immunohistochemistry. was identified 37.5% of specimens. Well-differentiated tumors expansive growth were associated with continuous periacinar, or cytoplasmic periacinar expression; poorly differentiated invasive showed interrupted vascular mesenchymal expression. absent controls but observed 67.5% cancers. Increased more common poor clinical characteristics. FN...
To investigate the effects of piperlongumine (PL) and vitamin C (VC) on signal transducer activator transcription 3 (STAT3) signalling in gastric cancer cell lines.In vivo tumour xenograft anticancer assays were undertaken to confirm activity PL. Cell viability, flow cytometry Western blot evaluate PL, VC combinations PL AGS KATO III cells.Both induced apoptosis inhibited proliferation cells. These dependent reactive oxygen species (ROS). effectively suppressed STAT3 activation while caused...
[b]Background[/b] The aim of this study was to evaluate the feasibility treating vertebral compression fractures using an autonomously developed nitinol memory alloy stent. [b]Material and Methods[/b] Thoracolumbar specimens from adult human cadavers were made into models fractures. divided group A, which received percutaneous kyphoplasty (PKP), balloon dilation, stent implantation (PKP + group); B, vertebroplasty (PVP) direct a (PVP C, PKP, bone cement polymethylmethacrylate (PMMA) group)....
At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet needs patients. The integrated theranostic system, in which functional materials are used load different active molecules, created a new developmental direction combination carcinoma, realizing synchronization treatment. In this study, polydopamine (PDA), has functions self-assembly, encapsulation, photothermal conversion, photoacoustic interaction, was as carrier material. IR780,...
Abstract this research was developed to investigate the expression level of miR520a-5p in serum fetal growth restriction (FGR) and role its target genes, mitogen-activated protein kinase (MAPK) 1 (MEK1), pathogenesis FGR. Thirty cases FGR group 30 normal birth weight (control group) were selected. MiR520a-5p genes MEK1 MAPK mRNA two groups detected by RT‒PCR. The levels determined Western blotting. Spearman grade correlation used analyze between expression. Compared with control group,...