About
Contact & Profiles
A5062599985
Research Areas
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
Institute of Biomedical Sciences, Academia Sinica
2020-2024
Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well patients receiving polyethylene glycol-functionalized drugs. Antibodies against PEG-coated nanocarriers can accelerate their clearance, but impact on nanodrug properties including nanocarrier integrity is unclear. Here, we show that anti-PEG IgG and IgM bind to PEG molecules the surface of liposomal doxorubicin (Doxil, Doxisome, LC-101, Lipo-Dox), resulting complement activation, formation membrane...
10.1021/acsnano.9b07218
article
EN
ACS Nano
2020-03-06
Binding of anti-PEG antibodies to poly(ethylene glycol) (PEG) on the surface PEGylated liposomal doxorubicin (PLD)
10.1021/acsnano.4c05409
article
EN
cc-by
ACS Nano
2024-08-09
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