Inflammation plays a critical role in cancer progression. In this study we investigate the pro-tumorigenic activities and gene expression profiles of lung cells after interaction with macrophages.We measured intratumoral microvessel counts macrophage density 41 tumor specimens correlated these patients' clinical outcome. The between macrophages cell lines was assessed using transwell coculture system. invasive potential evaluated by vitro invasion assay. matrix-degrading activity assayed...

Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing breathing difficulties to hypothermia, hypotension, death in the most severe cases. Because many normal individuals have pre-existing antibodies that bind poly(ethylene glycol) (PEG), which is often present on surface of nanomedicines drugs, we examined if how anti-PEG HSRs PEGylated liposomal doxorubicin (PLD). Anti-PEG IgG but not IgM induced including altered lung...

Methoxy polyethylene glycol (mPEG) is attached to many proteins, peptides, nucleic acids and nanomedicines improve their biocompatibility. Antibodies that bind PEG are present in individuals can be generated upon administration of pegylated therapeutics. Anti-PEG antibodies the "backbone" accelerate drug clearance detrimentally affect activity safety, but no studies have examined how anti-methoxy antibodies, which selectively terminus mPEG, drugs. Here, we investigated defined IgG IgM...

A new lignan glycoside, 4-O-α-l-arabinopyranosyl-(1' ''→2' ')-β-d-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure 2 was established by spectral analysis chemical methods. justicidin (1), diphyllin (3), tuberculatin (4) showed potent cytotoxic effects against a number cancer cells in vitro. Compounds 1 4 also strongly enhanced tumor-necrosis factor-α (TNF-α) generation mouse macrophage-like RAW...

ABSTRACT Background Daily chlorhexidine gluconate (CHG) bathing may reduce central line‐associated bloodstream infections (CLABSI) in critically ill patients, but evidence remains inconclusive, particularly regarding long‐term effects and varying frequencies of use. Aim This study aimed to examine the association between different CHG CLABSI rates medical intensive care units (MICUs). Study Design A retrospective analysis was conducted three MICUs northern Taiwan from March 2018 June 2022....

We had previously demonstrated that lung cancer cells, upon contact with macrophages, could be induced to secrete angiogenic factors promote tumor angiogenesis. In this study, we focused on the paracrine and autocrine regulation of interleukin (IL)-8 expression in sensitized cells after interacting macrophages. found IL-8 mRNA significantly increased coculture phorbol myristate acetate-treated THP-1 human primary Fresh CL1-5 cocultured macrophage-sensitized still a 35% increase expression....

In this study, a nanocomposite coating composed of polydopamine, functionalized poly(3,4-ethylenedioxythiophene) (PEDOT), and silver nanoparticles (AgNPs) was synthesized through layer-by-layer deposition. Biomimitic polydopamine hydroxyl-functionalized PEDOT were used to enhance the adhesion strength. The deposition with zwitterionic phosphorylcholine can contribute antifouling property. After immersion in AgNO3 solution, Ag+ ions adsorbed on films further reduced form AgNPs spontaneously,...

Binding of anti-PEG antibodies to poly(ethylene glycol) (PEG) on the surface PEGylated liposomal doxorubicin (PLD)

AFTIR (after flowing through immobilized receptor) is a novel method for screening herbal extracts pharmaceutical properties. Using AFTIR, we identified Cynarin in Echinacea purpurea by its selective binding to chip CD28, receptor of T-cells, which instrumental immune functioning. The results surface plasma resonance show that between CD28 and stronger than the CD80, co-stimulated antigen presenting cells. Cynarin's function was verified ability downregulate CD28-dependent interleukin-2...

Abstract Background Theophylline has been used widely as a bronchodilator for the treatment of bronchial asthma and suggested to modulate immune response. While importance macrophages in reappraised emphasized, their significance not well investigated. We conducted genome-wide profiling gene expressions response theophylline. Methods Microarray technology was profile expression patterns modulated by Northern blot real-time quantitative RT-PCR were also validate microarray data, while Western...

Ion implant is very important process in semiconductor manufacturing. In this study, we discuss a problem of low yield caused by an related defect on specific location and structure the device. The paper explains how general Failure Analysis (FA) techniques such as top view analysis Scanning Electron Microscope (SEM), Passive Voltage Contrast (PVC) cross section Focused Beam (FIB) coupled with Transmission Microscopy (TEM) are unable to identify which causes gate driver failure turn leads...

Precise defect positioning by EFA has become critically important for yield improvement due to the reduction in CMOS size and increase complexity. Some kind of leakage current caused metal defects could not be detected conventional Photo emission microscope (like InGaAs EMMI), because detector responds near-infrared light (NIR); therefore, Lock-in thermography (LIT) equipped with InSb camera is used detection mid-infrared wavelength (MIR), better sensitivity heat dissipation. The LIT system...

Described here is a method for navigating multiple mobile robots which estimate locations and motions of unknown moving objects. Each robot with conic projection image sensor COPIS can observe an omnidirectional view around the in real-time use mirror. First, each communicates exchanges information sensory data. Then, objects reciprocating are discriminated, estimated by cooperative observation azimuth changes between two robots. >

AA (Active Area) is a very critical layer, it related to the MOSFET devices operation. If structure of suffered damage, will cause device operate abnormally. Generally speaking, damage issue always discussed phenomenon, but few people really explored root in detail [1]. Because was unknown, we were unable perform an effective improvement on abnormality. In this paper, provide two identified causes for damage. One abnormal CoSi <sub xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Success in product development is a critical management issue for the modern firm, especially those technology driven industries. Opportunity identification initial stage new process where ideas are generated and screened. One interesting area use of neural networks event prediction. This research develops back-propagation network model prediction screening tests it using data from experts. A comparison predictive abilities both discriminate analysis method presented. On major drawbacks long...