A5054296849- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Chronic Myeloid Leukemia Treatments
- HIV, Drug Use, Sexual Risk
- Drug Transport and Resistance Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Hernia repair and management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Plant-based Medicinal Research
- Biosimilars and Bioanalytical Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Neurotransmitter Receptor Influence on Behavior
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Gallbladder and Bile Duct Disorders
- Acute Myeloid Leukemia Research
- Stoma care and complications
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
Bangalore Medical College and Research Institute
2023
Incyte (United States)
2020-2022
University of Florida
2020
Columbus Oncology and Hematology Associates
2020
University of North Carolina at Chapel Hill
2015-2019
Weatherford College
2015
Abstract Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (HCT) is a primary cause of nonrelapse mortality and major barrier to successful transplant outcomes. Itacitinib Janus kinase (JAK)1–selective inhibitor that has demonstrated efficacy in preclinical models aGVHD. We report results from the first registered study JAK patients with This was an open-label phase 1 enrolling aged ≥18 years HCT any source who developed grade IIB IVD Patients...
1. Antiretroviral concentrations in cerebrospinal fluid (CSF) are used as surrogate for brain tissue, although sparse data support this. We quantified antiretrovirals tissue across preclinical models, compared them to CSF, and calculated 90% inhibitory quotients (IQ90) nonhuman primate (NHP) tissue. Spatial distribution of efavirenz was performed by mass-spectrometry imaging (MSI). 2. HIV or RT-SHIV-infected uninfected animals from two humanized mouse models (hemopoietic-stem cell/RAG2-, n =...
For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs three preclinical animal models humans. found that standard dosing species closely mimicked tissue humans for some, but not all, ARVs. These results have implications interpreting treatment, prevention, or interventions between clinical models.
Drug transporters affect antiretroviral therapy (ART) tissue disposition, but quantitative measures of drug transporter protein expression across preclinical species are not available. Our objective was to use proteomics obtain absolute concentrations and assess agreement with corresponding gene immunometric data.In order make interspecies comparisons, two humanized mouse [hu-HSC-Rag (n = 41); bone marrow-liver-thymus 13)] one primate [rhesus macaque (nonhuman primate, n 12)] models were...
Itacitinib is a novel, selective, Janus kinase 1 inhibitor in development for treatment of graft-versus-host disease. The objective this study was to assess pharmacokinetics and safety 300-mg itacitinib dosed participants with normal renal function (n = 10), severe impairment 8), end-stage disease (ESRD) on hemodialysis 8). Serial plasma urine samples (urine from groups only) were collected before dosing until 72 hours after dosing. In the ESRD group, evaluated 2 periods, when (period 1) 2)...
Maraviroc-based regimens have been explored as preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). In this study, we utilized mucosal tissue drug exposure data, combined with target concentrations generated in vitro, a pharmacokinetic-pharmacodynamic analysis to predict the effects of combinations and adherence on PrEP efficacy. Mucosal maraviroc were measured 24 healthy women. The 90% effective (EC90) (alone tenofovir emtricitabine) for protection HIV identified CD4+...
Sparse data exist on the penetration of antiretrovirals into brain tissue. In this work, we present a framework to use efavirenz (EFV) pharmacokinetic (PK) in plasma, cerebrospinal fluid (CSF), and tissue eight rhesus macaques predict concentrations HIV-infected individuals. We then perform exposure-response analysis with model-predicted EFV area under concentration-time curve (AUC) neurocognitive scores collected from group 24 participants. Adult were dosed daily 200 mg (as part four-drug...
Although traditional approaches to biomarker discovery have elucidated key molecular markers that improved drug selection (precision medicine), the of biomarkers inform optimal dose dosing) continues be a challenge in many therapeutic areas. Larger and more diverse study populations are necessary discover additional provide resolution needed for tailored dose. To generate accommodate large datasets response phenotypes, time- cost-efficient strategies necessary. In particular, multitude...
BACKGROUND: Follicular variant of papillary thyroid carcinoma is relatively common carcinoma. Fine needle aspiration cytology (FNAC) an important investigation in preoperative diagnosis lesions. The follicular FNAC usually missed and challenging compared to classic OBJECTIVES: To assess the clinical histopathological features subtypes document that would improve sensitivity diagnosis. METHODS: Retrospective study histologically confirmed our institution over 5 years from 2009 2013.RESULTS:...
BACKGROUND: An umbilical hernia with a narrow neck and wide sac is more prone to complications, thus the morphology of an crucial in determining development symptoms consequences. The sac-neck ratio ultrasonographic ndings are used this study take into account physical properties order anticipate onset complications. MATERIALS AND METHODS: This prospective observational conducted Victoria Hospital from February 2021 July 2022.Atotal 115 patients underwent ultrasound abdomen note size...
Cholelithiasis is one of the most common conditions affecting gastrointestinal tract. For gallstone disease, laparoscopic cholecystectomy has emerged as preferred method surgery. The use expanding in circumstances where surgery was previously contraindicated. By accurately anticipating challenging nature before surgery, many difculties these cases can be avoided. Recent advances say that Gall bladder wall thickness crucial factor determining cholecystectomy.