A5060170825- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Agriculture Sustainability and Environmental Impact
- Eicosanoids and Hypertension Pharmacology
- Dialysis and Renal Disease Management
- Hormonal Regulation and Hypertension
- Nutrition and Health in Aging
- Frailty in Older Adults
- Estrogen and related hormone effects
- Bladder and Urothelial Cancer Treatments
- Thermoregulation and physiological responses
- Hippo pathway signaling and YAP/TAZ
- Antioxidant Activity and Oxidative Stress
- Musculoskeletal pain and rehabilitation
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Opioid Use Disorder Treatment
- Sexual function and dysfunction studies
- Cancer Risks and Factors
- Pressure Ulcer Prevention and Management
- Nutritional Studies and Diet
Eli Lilly (United States)
2025
San Francisco VA Medical Center
2019-2024
University of California, San Francisco
2014-2024
San Francisco VA Health Care System
2021-2024
University of Colorado Denver
2024
Universitetshospitalernes Center for Sundhedsfaglig Forskning
2021
University of San Francisco
2019
Advisory Board Company (United States)
2016-2018
IFC Research (United Kingdom)
2018
Online Technologies (United States)
2018
Hypotension is common during tracheal intubation of critically ill adults and increases the risk cardiac arrest death. Whether administering an intravenous fluid bolus to undergoing prevents severe hypotension, arrest, or death remains uncertain.
As cystatin C is increasingly adopted to estimate glomerular filtration rate (eGFR), clinicians will encounter patients in whom C-based eGFR (eGFRcys) and creatinine-based (eGFRcr) differ widely. The clinical implications of these differences, eGFRdiffcys-cr, are unknown.To evaluate the associations eGFRdiffcys-cr with end-stage kidney disease (ESKD) mortality among individuals chronic (CKD).This a prospective cohort study 4956 mild moderate CKD from 7 centers United States who enrolled...
Abstract Background Plant‐based diets have many health benefits, including a lower risk of fatal prostate cancer, and greater environmental sustainability. However, less is known regarding the impact plant‐based on quality life among individuals diagnosed with cancer. The authors' objective was to examine relationship between diet indices postdiagnosis life. Methods This prospective cohort study included 3505 participants in Health Professionals Follow‐Up Study (1986–2016) nonmetastatic...
Lower urinary tract symptoms (LUTS) in older men are associated with an increased risk of mobility limitations. extremity muscle quality may represent a novel shared mechanism both LUTS and We evaluated associations thigh skeletal measures (strength, area, specific force) total severity (American Urologic Association Symptom Index; AUASI) voiding storage subscores among 352 aged ≥60 years enrolled the Baltimore Longitudinal Study Aging. Thigh strength (Nm) was defined as maximum concentric...
A higher difference in estimated glomerular filtration rate by cystatin C versus creatinine (eGFRDiff = eGFRCys - eGFRCreat) is associated with decreased frailty risk. Since eGFRCreat influenced muscle more than eGFRCys, mass may explain this association. Previous work could not account for when considering regional measures imaging. Deuterated creatine (D
<h3>Importance</h3> Erectile dysfunction, especially in younger men, is an early sign of cardiovascular disease and may decrease quality life. Men be motivated to adopt a healthy dietary pattern if it lowers their risk erectile dysfunction. <h3>Objective</h3> To assess the association between adherence diet index based on patterns dysfunction men. <h3>Design, Setting, Participants</h3> This population-based prospective cohort study included men from Health Professionals Follow-up Study with...
To estimate associations between lower urinary tract symptoms (LUTS) and phenotypic frailty in older men.
BACKGROUND Observational studies suggest an inverse association between selenium and risk of prostate cancer. However, randomized controlled trials supplementation have reported conflicting results. Thus, we examined plasma selenium-related genes in relation to high-grade cancer recurrence among men initially diagnosed with non-metastatic disease. METHODS We measured genotyped 73 single nucleotide polymorphisms TXNRD1, TXNRD2, GPX1, GPX3, GPX4, SEP15, SEPP1, SELENBP1, OGG1, CAT 568 who...
Abstract Background Older men frequently develop lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Risk factors for LUTS/BPH include sedentary lifestyle, anxiety/depression, obesity, and frailty, which all increase with age. Although physical exercise may reduce the progression and/or severity of LUTS/BPH, age-related mechanisms responsible remain unknown. Methods Voiding symptoms, body mass, frailty were assessed after 4-weeks voluntary wheel running in...
Observational studies suggest an inverse association between vitamin E and risk of prostate cancer, particularly aggressive tumors. However, three large randomized controlled trials have reported conflicting results. Thus, we examined circulating E-related genes in relation to high-grade cancer recurrence among men initially diagnosed with clinically organ-confined disease.We measured α- γ-tocopherol genotyped 30 SNPs SOD1, SOD2, SOD3, TTPA, SEC14L2 573 who underwent radical prostatectomy....
Age is the greatest risk factor for lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Although LUTS/BPH can be managed with pharmacotherapy, treatment failure has been putatively numerous pathological features of BPH (eg, fibrosis, inflammation). Mitochondrial dysfunction a hallmark aging; however, its impact on remains unknown. Publicly available gene array data were analyzed. Immunohistochemistry examined mitochondrial proteins in human prostate. The...
Inhibition of proliferative neointima formed by vascular smooth muscle cells is a potential target in preventing angioplasty-induced restenosis. We have created potent antiproliferative fusing the active regions p27 and p16 cell cycle inhibitors. Intravascular delivery replication-deficient adenoviral vector (AV) encoding this p27-p16 fusion protein, named W9, inhibited balloon injury-induced neointimal hyperplasia rabbit carotid arteries. In therapeutically more relevant model, AV-W9 was...
Background Patients with chronic noncancer pain treated higher doses of opioids or concurrent substance use are at increased risk adverse events. Although several national guidelines recommend maximum dosing thresholds and urine drug testing, adherence to these is inconsistent. Methods To identify predictors higher-risk opioid prescriptions in 2 academic primary care clinics, the authors developed a retrospective cohort 842 patients who were prescribed ≥5 for between March 2012 2013. The...
<h3>Importance</h3> Benign prostatic hyperplasia (BPH) in older men can cause lower urinary tract symptoms (LUTS), which are increasingly managed with medications. Frailty may contribute to both symptom progression and serious adverse events (SAEs), shifting the balance of benefits harms drug therapy. <h3>Objective</h3> To assess association between a deficit accumulation frailty index clinical BPH or SAE. <h3>Design, Setting, Participants</h3> This cohort study used data from Medical...