A5090952116- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Pain Mechanisms and Treatments
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Child Nutrition and Feeding Issues
- Neurogenetic and Muscular Disorders Research
- Tracheal and airway disorders
- Migraine and Headache Studies
- Parkinson's Disease and Spinal Disorders
- Myasthenia Gravis and Thymoma
- Amyotrophic Lateral Sclerosis Research
- Musculoskeletal pain and rehabilitation
- Peripheral Nerve Disorders
- Neuroscience and Neural Engineering
- Multiple Sclerosis Research Studies
- Trigeminal Neuralgia and Treatments
- Long-Term Effects of COVID-19
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2013-2025
Urology Foundation
1999-2022
Foundation Center
2013-2020
Ospedale Vincenzo Cervello
2013-2020
Institute for Biomedical Research and Innovation
2020
National Academies of Sciences, Engineering, and Medicine
2020
University of Pavia
2002-2019
Mayo Clinic
2019
University College London
2019
Istituto delle Scienze Neurologiche di Bologna
2019
To assess the prevalence and isotypes of anti-nodal/paranodal antibodies to nodal/paranodal proteins in a large chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cohort, compare clinical features seronegative vs seropositive patients, gather evidence their isotype-specific pathogenic role.
After extensive evaluation, one-third of patients affected by polyneuropathy remain undiagnosed and are labelled as having chronic idiopathic axonal polyneuropathy, which refers to a sensory or sensory-motor, axonal, slowly progressive neuropathy unknown origin. Since neuropathy/neuronopathy is identified in all with genetically confirmed RFC1 cerebellar ataxia, neuropathy, vestibular areflexia syndrome, we speculated that expansions could underlie fraction neuropathies also diagnosed...
Acute disseminated encephalomyelitis (ADEM) refers to a monophasic acute multifocal inflammatory CNS disease. However, both relapsing and site-restricted variants, possibly associated with peripheral nervous system (PNS) involvement, are also observed, systematic classification is lacking.To describe cohort of postinfectious ADEM patients, propose based on clinical instrumental features, identify subgroups patients different prognostic factors.Inpatients Neurologic Infectious Disease Clinic...
<b>Objectives: </b> To assess the presence, severity, and differences in dysphagia Parkinson disease (PD), variant of multiple system atrophy (MSA-P), progressive supranuclear palsy (PSP), to study pathophysiology swallowing abnormalities these disorders. <b>Methods: We applied an electrophysiologic method evaluate oral-pharyngeal swallowing. analyzed following measures: duration EMG activity suprahyoid/submental muscles (SHEMG-D); laryngeal–pharyngeal mechanogram (LPM-D); inhibition...
Botulinum toxin (BTX) injection into the cricopharyngeal (CP) muscle has been proposed for treatment of neurogenic dysphagia due to CP hyperactivity. The aim was determine whether an electrophysiological method exploring oropharyngeal swallowing could guide and discriminate responders from non-responders, based on association dysfunction with other abnormalities swallowing.Patients different neurological disorders were examined: Parkinson disease, progressive supranuclear palsy, multiple...
Abstract Abnormal postures of the trunk are a typical feature Parkinson's disease (PD). These include Pisa syndrome (PS), tonic lateral flexion associated with slight rotation along sagittal plane. In this study we describe clinical, electromyographic (EMG), and radiological features PS in group 20 PD patients. All patients deviation underwent EMG (RX CT scan) investigation. Clinical characteristics were compared control without deviation. showed significantly higher score asymmetry group....
During the recent Coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing Acute Motor-Sensory Axonal Neuropathy, variant of Guillain-Barré syndrome (GBS), twelve days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation immune system due post-infectious mechanisms, such as molecular mimicry, could lead an indirect damage peripheral nervous related...
Coronavirus disease 2019 (COVID-19), a caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become global pandemic. Patients with myasthenia gravis (MG), often treated immunosuppressants, might be at higher risk of developing COVID-19 and demonstrating course. We aimed to study prevalence describe features in MG patients.In May 2020, we conducted telephonic interviews patients followed our referral center. collected structured data regarding COVID-19, which...
Electromyography (EMG) was performed in 10 patients with multiple system atrophy, laryngeal or pharyngeal symptoms, both. In stridor, EMG during quiet breathing revealed persistent tonic activity both abductor and adductor vocal cord muscles. dysphagia, the cricopharyngeal muscle showed throughout all phases of swallowing. Botulinum toxin injection into determined subjective improvement reduced activity. Therefore, cause stridor atrophy is dystonia cords.
The "off" painful dystonia (OPD), usually concerning the feet, is a type of abnormal involuntary movement, induced by chronic use levodopa. It mostly observed in advanced stage Parkinson's disease (PD), particularly early morning, evening, and late at night. Indeed, some patients have experienced OPD also during "on" periods when dystonic posture foot alternates with dyskinesia. pain probably due to sustained muscle contraction, which causes prolonged spasm, as primary or torticollis....
Postinfectious neurologic syndromes (PINSs) of the CNS include heterogeneous disorders, sometimes relapsing. In this study, we aimed to a) describe spectrum PINSs; b) define predictors outcome in and c) assess clinical/paraclinical features that help differentiate PINSs from multiple sclerosis (MS).In prospective cohort adult inpatients with underwent extensive diagnostic assessment therapeutic protocols at inclusion during a minimum 2-year follow-up. We compared them newly diagnosed,...
We investigated 8 healthy male volunteers, evaluating RII and RIII thresholds every 6 h starting from noon, for a 24-h period. Both reflex responses exhibited circadian rhythmicity: the lowest values were found in early morning (9.1 ± 3.0 13.1 4.4 mA, respectively), while highest observed at midnight (13.1 3.5 18.5 5.3 mA). Also mean cosinor analysis indicated existence of significant rhythm with acrophase 20:12 22:29 RIII. In 4 subjects, β-endorphin plasma (β-EP) level was tested during...
In order to evaluate the role of endogenous opioids in sustaining analgesia induced by transcutaneous nerve stimulation (TNS), we measured plasma beta-lipotropin (BLPH), beta-endorphin (BEP), ACTH and cortisol changes concomitantly with nociceptive flexion reflex (RIII) threshold after TNS (80 microseconds rectangular waves at 85 Hz) a group healthy volunteers (A). The same protocol was carried out another using placebo (0.5 (B). RIII significantly increased 0.5 h A no were recorded B....
Background and Aims: Neurogenic dysphagia linked to failed relaxation of the upper esophageal sphincter (UES) can be treated by injecting botulinum toxin (BTX) into cricopharyngeal (CP) muscle. We compared effects this treatment in different neurological disorders with dysphagia, evaluate its efficacy over time including response a second injection. Materials Methods: Sixty-seven patients neurogenic associated incomplete or absent opening UES (24 brainstem hemispheric stroke, 21 parkinsonian...