A5037413796- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- RNA Research and Splicing
- Obsessive-Compulsive Spectrum Disorders
- Ion channel regulation and function
- Neurofibromatosis and Schwannoma Cases
- Veterinary medicine and infectious diseases
- Multiple Sclerosis Research Studies
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Adrenal Hormones and Disorders
- Photochromic and Fluorescence Chemistry
- Peripheral Nerve Disorders
- Neurogenetic and Muscular Disorders Research
- RNA Interference and Gene Delivery
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
Centre National de la Recherche Scientifique
2015-2020
Université de Bordeaux
2019-2020
Institut Interdisciplinaire de Neuroscience
2019-2020
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2015-2019
Aix-Marseille Université
2015-2019
University of Pavia
2016-2019
Fondazione IRCCS Istituto Neurologico Carlo Besta
2019
University College London
2019
National University of Singapore
2016
The University of Sydney
2016
We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies.
Chronic inflammatory demyelination polyneuropathy is a heterogeneous and treatable immune-mediated disorder that lacks biomarkers to support diagnosis. Recent evidence indicates paranodal proteins (contactin 1, contactin-associated protein neurofascin-155) are the targets of autoantibodies in subsets patients showing distinct clinical presentations. Here, we identified neurofascin-186 neurofascin-140 as main five presenting IgG reactivity against nodes Ranvier. Four displayed predominantly...
A Spanish group recently reported that four patients with chronic inflammatory demyelinating polyneuropathy carrying IgG4 autoantibodies against contactin 1 showed aggressive symptom onset and poor response to intravenous immunoglobulin. We aimed describe the clinical serological features of Japanese displaying anti-contactin antibodies. Thirteen 533 (2.4%) had whereas neither from disease or normal control subjects did (P = 0.02). Three 13 (23%) subacute onset, but all presented sensory...
To assess the prevalence and isotypes of anti-nodal/paranodal antibodies to nodal/paranodal proteins in a large chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cohort, compare clinical features seronegative vs seropositive patients, gather evidence their isotype-specific pathogenic role.
Paranodal axoglial junctions formed by the association of contactin-1, contactin-associated protein 1, and neurofascin-155, play important functions in nerve impulse propagation along myelinated axons. Autoantibodies to contactin-1 neurofascin-155 define chronic inflammatory demyelinating polyradiculoneuropathy subsets patients with specific clinical features. These autoantibodies are mostly IgG4 isotype, but their pathogenicity has not been proven. Here, we investigated mechanisms how IgG...
Neurofascin-155 (Nfasc155) is an essential glial cell adhesion molecule expressed in paranodal septate-like junctions of peripheral and central myelinated axons. The genetic deletion Nfasc155 results the loss conduction slowing. In humans, IgG4 antibodies against are implicated pathogenesis chronic inflammatory demyelinating polyneuropathy (CIDP). These associated with aggressive onset, a refractoriness to intravenous immunoglobulin, tremor possible cerebellar origin. Here, we examined...
Astrocytes constantly adapt their ramified morphology in order to support brain cell assemblies. Such plasticity is partly mediated by ion and water fluxes, which rely on the channel aquaporin-4 (AQP4). The mechanism this locally contributes process dynamics has remained elusive. Using a combination of single-molecule calcium imaging approaches, we here investigated hippocampal astrocytes dynamic distribution AQP4 isoforms M1 M23. Surface AQP4-M1 formed small aggregates that contrast with...
Combined central and peripheral demyelination (CCPD) encompasses a wide array of disorders ranging from myeloradiculoneuritis encephalomyeloradiculoneuritis, which often occur after infection or vaccination, to co-occurrence multiple sclerosis (MS) chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).1,2 Acknowledgment: The authors thank Dr. Isabel Illa (Hospital de la Santa Creu I Sant Pau Barcelona, Universitat Autònoma Spain) for providing the control NF155-positive CIDP...
Hippocampal pyramidal neurons are characterized by a unique arborization subdivided in segregated dendritic domains receiving distinct excitatory synaptic inputs with specific properties and plasticity rules that shape their respective contributions to integration action potential firing. Although the basal regulation plastic range of proximal distal synapses known be different, composition nanoscale organization key proteins at these remains largely elusive. Here we used superresolution...