A5100418663- Fluid Dynamics and Turbulent Flows
- Lung Cancer Treatments and Mutations
- Wind and Air Flow Studies
- RNA modifications and cancer
- Fluid Dynamics and Vibration Analysis
- Particle Dynamics in Fluid Flows
- Heat Transfer Mechanisms
- Cancer Immunotherapy and Biomarkers
- Lattice Boltzmann Simulation Studies
- Ferroptosis and cancer prognosis
- Computational Fluid Dynamics and Aerodynamics
- Combustion and flame dynamics
- Aerodynamics and Acoustics in Jet Flows
- Meteorological Phenomena and Simulations
- Plant Water Relations and Carbon Dynamics
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Quinazolinone synthesis and applications
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Industrial Technology and Control Systems
- Granular flow and fluidized beds
- Melanoma and MAPK Pathways
- Aerodynamics and Fluid Dynamics Research
- Eosinophilic Disorders and Syndromes
Tsinghua University
2016-2025
Ono Pharmaceutical (United States)
2022-2025
Shuozhou Central Hospital
2025
East China Normal University
2022-2024
Zhejiang Center for Disease Control and Prevention
2023-2024
Chinese Academy of Sciences
2015-2023
Zhejiang Province Institute of Architectural Design and Research
2023
Zhejiang University
2023
Institute of Electrical Engineering
2020-2023
Aerospace Research Institute of Materials and Processing Technology
2023
The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non-small lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrative approach define novel therapeutic targets KRAS-driven LKB1-mutant cancers. High-throughput RNA interference screens cancer lines from genetically engineered mouse models driven by activated or...
Drag reduction in turbulent channel and pipe e ows by spanwise (circumferential) wall oscillations is studied numerically. The ine uence of the oscillation on near-wall streamwise vortices examined. By use Stokes second problem, a wall-normal distanceparameter an acceleration parameterare obtained toestimate drag rate. A simple equation derived for expressing rate oscillations. relation between low- high-speed uids scrutinized to extract key parameters. mechanism analyzed terms attenuation...
Finite dilatational effects in wall-bounded compressible turbulence are investigated. We find that finite correlation between the solenoidal and parts of velocity field account for a nonnegligible fraction turbulent shear stress near walls.
Direct numerical simulations of turbulent channel flow at Reτ = 205 and 932 have been carried out to examine Taylor’s “frozen turbulence” hypothesis. The terms in hypothesis appear the transport equation for instantaneous momentum (Navier-Stokes) this flow. additional terms, i.e., convective acceleration term pressure gradient viscous force act diminish validity when they are relatively large compared not balance. A similar analysis has applied vorticity. equation, namely, rates change...
Compressibility effects on velocity and temperature fluctuations in hypersonic turbulence over cold walls are investigated by exploiting a direct numerical simulation database. We found that the compressibility enhanced decrease wall temperature, which is directly reflected rapid increase divergence turbulent Mach number. Helmholtz decomposition adopted to evaluate genuine splitting fluctuation into solenoidal component dilatational component. As decreases, vertical motion gradually...
Direct numerical simulations of particle-laden turbulent channel flows at friction Reynolds number $Re_\tau$ from $600$ to $2000$ have been performed examine the near-wall particle streaks. Different well-observed small-scale streaks in turbulence low , present results show large-scale through computational domain formed for relatively high-inertia particles high . Transferred by sweep and ejection events ( $Q^-$ ), these preferentially accumulate regions beneath low-speed flow observed...
Dilatational motions in the shape of travelling wave packets have been identified recently to be dynamically significant hypersonic turbulent boundary layers. The present study investigates mechanisms their generation and association with solenoidal motions, especially well-recognized near-wall self-sustaining process regeneration cycle between velocity streaks quasi-streamwise vortices. By exploiting direct numerical simulation databases orchestrating experiments, we explore systematically...
A hybrid immersed boundary/wall-model approach for large eddy simulation is developed turbulent flows with complex/moving boundaries. The filtered Navier-Stokes equations are solved on a regular Eulerian mesh, the no-slip condition wall imposed through continuous forcing of boundary (IB) method. To implement model, thin layer equation an embedded mesh refined along wall-normal direction and dynamic matching procedure adopted. Near-wall subgrid-scale viscosity further modified by taking into...
Very-large-scale motions are commonly observed in moderate- and high-Reynolds-number wall turbulence, constituting a considerable portion of the Reynolds stress skin friction. This study aims to investigate behaviour these high-speed turbulent boundary layers at varying Mach numbers. With aid high-precision numerical simulations, experiments theoretical analysis, it is demonstrated that very-large-scale weakened high-Mach-number turbulence same friction numbers, leading reduction kinetic...
In the present study, we perform direct numerical simulations of compressible turbulent boundary layers at free stream Mach numbers $2\unicode{x2013}6$ laden with dilute phase spherical particles to investigate number effects on particle transport and dynamics. Most phenomena observed well-recognized for inertia in incompressible wall-bounded flows – such as near-wall preferential accumulation clustering beneath low-speed streaks, flatter mean velocity profiles, trend variation fluctuations...
In the literature, a major discrepancy is reported between value of kurtosis for normal velocity fluctuations close to wall as found from direct numerical simulations and obtained experiments. The origin these high levels analyzed with help simulation turbulent channel flow. addition, detailed analysis LDV measurements in near-wall region pipe flow made results DNS starting point. both data sets, i.e. experiments, similar events were that contribute level. dynamics can be associated...
Abstract Near-wall streamwise vortices are closely related to the generation of high skin friction in wall-bounded turbulent flows. A common feature controlled, friction-reduced flows is weakened near-wall vortices. In present study, streak transient growth (STG) mechanism for generating by Schoppa & Hussain ( J. Fluid Mech. , vol. 453, 2002, pp. 57–108) employed, and opposition control proposed Choi, Moin Kim 262, 1994, 75–110) imposed during process perturbations determine how active...
Compressibility effects on pressure fluctuations in wall-bounded turbulent flows at various Mach numbers are investigated by deriving a Poisson equation that allows splitting into rapid and slow terms, as incompressible flows, additional mass-flux viscous terms. The terms further split their solenoidal dilatational components using Helmholtz decomposition. found to be independent of number similar whereas the increase quadratically with number.
The effect of mass loading on turbulence modulation in channel flows is investigated two-way coupled direct numerical simulations with the Lagrangian point-particle method. We carried out turbulent at Reτ = 180, and particle ranges from 0 to 0.96 a fixed Stokes number St 30. statistics show that intensity streamwise velocity fluctuation augmented non-monotonically increase loading. maximum enhancement observed mass-loading ϕm 0.75 60% greater than unladen flow. However, fluctuations spanwise...
Abstract
Marine microorganisms must cope with complex flow patterns and even turbulence as they navigate the ocean. To survive avoid predation find efficient energy sources. A major difficulty in analysing possible survival strategies is that time series of environmental cues non-linear complex, it depends on decisions taken by organism. One way determining evaluating optimal reinforcement learning. In a proof-of-principle study, Colabrese et al. [Phys. Rev. Lett. (2017)] used this method to out how...
The complex behaviours of supersonic turbulent boundary-layer flows interacting with combustion is explored through the use direct numerical simulations. chosen flow model a non-premixed hydrogen–air flame ignited within three-dimensional flat-plate boundary layer operating at Mach number 2.33 and friction Reynolds approximately 1000. simulation involves finite-rate for reaction including 9 species 19 steps adiabatic non-catalytic wall conditions. inlet consists preheated air in main stream...
In this study, a data-driven method for the construction of reduced-order model (ROM) complex flows is proposed. The uses proper orthogonal decomposition (POD) modes as basis and dynamic mode to obtain linear equations temporal evolution coefficients modes. This eliminates need governing involved, therefore saves effort deriving projected proving their consistency, convergence stability, required by conventional Galerkin projection method, which has been successfully applied incompressible...
In the present study, we perform direct numerical simulations to investigate spatial development and basic flow statistics in supersonic turbulent boundary layers at free-stream Mach number of 2.0 over smooth disturbed walls, latter which enforces extra Reynolds shear stress streamwise direction emulate drag increment mean streamline curvature effects rough walls. Such disturbances escalate growth rate layer thickness shape factor. It is found that under rescaled global coordinate, velocity,...
The oblique shock impinging on the supersonic turbulent boundary layer leads to a mixing and emergence of large-scale coherent structures within interaction zone which leave significant velocity defect turbulence amplification downstream. In present study, we investigate recovery in post-shock region by exploiting direct numerical simulation data oblique-shock/turbulent flow at incoming Mach number $2.28$ angle $33.2^\circ$ , with special attention paid contribution dynamics. For that...