Phoebe Ivain
A5021239416- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Metabolism and Genetic Disorders
- Dialysis and Renal Disease Management
- Cerebral Palsy and Movement Disorders
- Down syndrome and intellectual disability research
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Maternal and Perinatal Health Interventions
- Chronic Disease Management Strategies
King's College London
2025
Imperial College London
2019-2023
BackgroundAlthough therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy low-income middle-income countries is unclear. We aimed to examine whether alongside optimal supportive intensive care moderate severe south Asia.MethodsWe did a multicountry open-label, randomised controlled trial seven tertiary units India, Sri Lanka, Bangladesh. enrolled infants born at 36 weeks of gestation with need for continued...
Importance The association between place of birth and hypothermic neuroprotection after hypoxic-ischemic encephalopathy (HIE) in low- middle-income countries (LMICs) is unknown. Objective To ascertain the efficacy whole-body hypothermia for protection against brain injury measured by magnetic resonance (MR) biomarkers among neonates born at a tertiary care center (inborn) or other facilities (outborn). Design, Setting, Participants This nested cohort study within randomized clinical trial...
Abstract INTRODUCTION The Cambridge Cognitive Examination modified for use in people with Down syndrome (CAMCOG‐DS) is a sensitive cognitive test Alzheimer's disease (AD)–related decline DS, but needs updates sensitivity, cultural adaptability, and additional memory/executive function items. This study aimed to develop validate the CAMCOG‐DS‐II. METHODS In this multi‐language, multi‐site study, psychometric properties of CAMCOG‐DS‐II were evaluated against previously validated measures 223...
We examined the association of Total Sarnat Score (TSS) with brain injury on neonatal magnetic resonance (MR) and adverse neurodevelopmental outcome (NDO) (death or moderate severe disability) at 2 years age in 145 infants undergoing therapeutic hypothermia for encephalopathy. TSS was associated basal ganglia/thalamic conventional MR (p=0.03) thalamic N-acetyl aspartate spectroscopy (R2=0.16, p=0.004) weeks age, Bayley Composite Cognitive (R2=0.18, p=0.01), Motor (R2=0.15, p=0.02) Language...
A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate development neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth, predicts neurodevelopmental eighteen months neonatal encephalopathy. performed next generation sequencing on ribonucleic acid obtained within six hours birth from first 47 recruited Hypothermia for Encephalopathy in Low middle-income countries (HELIX) trial. Two infants...
BackgroundAlthough thalamic magnetic resonance (MR) spectroscopy (MRS) accurately predicts adverse outcomes after neonatal encephalopathy, its utility in infants without MR visible deep brain nuclei injury is not known. We examined MRS metabolite perturbations encephalopathic with white matter (WM) or cortical and associations outcomes.MethodsWe performed a subgroup analysis of all recruited to the MARBLE study isolated WM mixed WM/cortical injury, but no basal ganglia/thalamus (BGT)...