A5069973098- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Spinal Dysraphism and Malformations
- Spinal Cord Injury Research
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Infectious Diseases and Tuberculosis
- Spinal Hematomas and Complications
- Vascular Malformations Diagnosis and Treatment
- Anesthesia and Pain Management
- Intracranial Aneurysms: Treatment and Complications
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Sarcoma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
Medical College of Wisconsin
2016-2025
Neurological Surgery
2015-2025
Froedtert Hospital
2022-2025
University of California, San Francisco
2021-2023
XinHua Hospital
2022
Lutheran Hospital
2022
University of California System
2022
Children's Hospital of Wisconsin
2016-2018
Neurosciences Institute
2015
Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received great deal of interest in recent years as potential target for the development new therapeutics against melanoma and glioblastoma tumors. Despite strong obtaining structural information, only structures apo-AC enzyme its zymogen activated conformations are available. In this work, crystal structure AC complex with covalent carmofur inhibitor presented. Carmofur an antineoplastic drug containing electrophilic...
There is a learning curve for surgeons performing "awake" spinal surgery. No comprehensive guidelines have been proposed the selection of ideal candidates awake fusion or decompression. The authors sought to formulate an algorithm aid in patient who are startup phase surgery.The developed selecting patients appropriate decompression using anesthesia supplemented with mild sedation and local analgesia. anesthetic protocol that was used has previously reported literature. This formulated based...
Prospective observational study, level of evidence 1 for prognostic investigations.To evaluate the prevalence sleep impairment and predictors improved quality 24 months postoperatively in cervical spondylotic myelopathy (CSM) using outcomes database.Sleep disturbances are a common yet understudied symptom CSM.The database was queried patients with CSM, assessed through neck disability index component at baseline postoperatively. Multivariable logistic regressions were performed to identify...
OBJECTIVE Cervical spondylotic myelopathy (CSM) can cause significant difficulty with driving and a subsequent reduction in an individual’s quality of life due to neurological deterioration. The positive impact surgery on postoperative patient-reported capabilities has been seldom explored. METHODS CSM module the Quality Outcomes Database was utilized. Patient-reported ability assessed via section Neck Disability Index (NDI) questionnaire. This is ordinal scale which 0 represents absence...
OBJECTIVE Cervical spondylotic myelopathy (CSM) can be associated with urinary dysfunction, leading to an inability or marked difficulty micturition. This study aimed evaluate the long-term prognosis, and recovery in patients CSM following surgical intervention. METHODS The cases of Quality Outcomes Database SpineCORe group were analyzed. Urinary control was assessed using modified Japanese Orthopaedic Association (mJOA) function subscore. Improvement defined as a minimum improvement 1 point...
Study Design Retrospective cohort study. Objectives Obesity and metabolic syndrome have become a common comorbidity among patients undergoing spine surgery. This study aimed to evaluate 30-day postoperative outcomes following cervical laminoplasty, stratified by BMI categories the presence of syndrome. Methods utilized 2007-2022 ACS-NSQIP database. Patients who underwent laminoplasty were identified categorized into six groups, according World Health Organization guidelines, based on The...
Assessment of bone quality can guide spinal surgery. However, surgeons infrequently evaluate in a quantitative manner. Recent literature suggests role for computed tomography (CT) Hounsfield units (HUs) as marker quality. Limited data exist regarding its utility with respect to posterolateral lumbar fusion (PLF).From fall 2010 winter 2012, 10 patients underwent revision surgery symptomatic pseudoarthrosis (defined intractable pain associated either radiographic evidence nonunion or...
Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology.With the SEER-18 registry database, information from all patients diagnosed with intracranial HB 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent receipt radiation, tumor size, location, and follow-up data. Age-adjusted incidence rates overall survival (OS). Cox proportional hazards model was employed for both univariate multivariate...
Lumbar back pain and radiculopathy are common diagnoses. Unfortunately, conventional magnetic resonance imaging (MRI) findings clinical symptoms do not necessarily correlate in the lumbar spine. With upright imaging, disc pathologies or foraminal stenosis may become more salient, leading to improvements diagnosis.Seventeen adults (10 asymptomatic 7 symptomatic volunteers) provided their informed consent participated study. A 0.6T MRI scan was performed on each adult seated position....
Glioblastoma can mimic various pathologies, including arteriovenous malformation, hemorrhage from ischemic stroke, cerebral contusion, metastatic disease, lymphoma, and infection. The literature is limited regarding diagnostic confusion with meningioma. Herein, we present 2 patients that exhibited imaging, angiography during preoperative embolization, which was consistent meningioma, but where final surgical diagnosis revealed glioblastoma.Case 1 a 57-year-old woman presenting headache,...
As the opioid epidemic accelerates in United States, numerous sociodemographic factors have been implicated its development and are, furthermore, a driving factor of disparities postoperative pain management. Recent studies suggested potential associations between influence race ethnicity on perception but also presence unconscious biases treatment minority patients.To characterize perioperative requirements across racial groups after spine surgery.A retrospective, observational study 1944...
OBJECTIVE Conventional MRI is routinely used to demonstrate the anatomical site of spinal cord injury (SCI). However, quantitative and qualitative imaging parameters have limited use in predicting neurological outcomes. Currently, there are no reliable neuroimaging biomarkers predict short- long-term outcome after SCI. METHODS A prospective cohort 23 patients with SCI (19 cervical [CSCI] 4 thoracic [TSCI]) treated between 2007 2014 was included study. The American Spinal Injury Association...