A5077644083- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Spinal Cord Injury Research
- Neuroblastoma Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Management of metastatic bone disease
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Medical Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Shoulder Injury and Treatment
- Spinal Hematomas and Complications
- Lung Cancer Research Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Polish Historical and Cultural Studies
- Nerve Injury and Rehabilitation
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- Spinal Dysraphism and Malformations
New York Hospital Queens
2019-2025
Neurological Surgery
2019-2025
NewYork–Presbyterian Hospital
2019-2025
Cornell University
2019-2025
Weill Cornell Medicine
2021-2025
Presbyterian Hospital
2020-2024
Médecins Sans Frontières
2024
Texas Health Dallas
2021-2024
Memorial Sloan Kettering Cancer Center
2020-2023
Médecins Sans Frontières
2021-2023
The addition of immunotherapy, including a combination anti-GD2 monoclonal antibody (mAb), ch14.18, and cytokines, improves outcome for patients with high-risk neuroblastoma. However, this therapy is limited by ch14.18-related toxicities that may be partially mediated complement activation. We report the results phase I trial to determine maximum-tolerated dose (MTD), safety profile, pharmacokinetics hu14.18K322A, humanized mAb single point mutation (K322A) reduces complement-dependent...
<h3>ABSTRACT</h3> The human intervertebral disc (IVD) is a complex organ composed of fibrous and cartilaginous connective tissues, it serves as boundary between 2 adjacent vertebrae. It provides limited range motion in the torso well stability during axial compression, rotation, bending. Adult IVDs have poor innate healing potential due to low vascularity cellularity. Degenerative disease (DDD) generally arises from disruption homeostasis maintained by structures IVD, genetic environmental...
OBJECTIVE Chronic subdural hematoma (cSDH) is a common and challenging pathology to treat due both the historically high recurrence rate following surgical evacuation medical comorbidities inherent in aging patient population that it primarily affects. Middle meningeal artery (MMA) embolization has shown promise treatment of cSDHs, most convincingly avoid relatively asymptomatic patients. Symptomatic patients requiring may also benefit from perioperative MMA prevent cSDH recurrence. The goal...
Background Addition of anti‐GD2 antibody ch14.18 to the treatment neuroblastoma has improved outcomes. The most common side effect is neuropathic pain, which may in part be complement‐mediated. Hu14.18K322A a humanized designed diminish complement activation and induce less pain. We compare pain outcomes patients treated with those hu14.18K322A, explore dose‐dependent relationships between scores, opioid requirements, levels hu14.18K322A. Procedure Opioid (morphine equivalent mg/kg)...
Image-guided spinal surgery (IGSS) underwent rapid development over the past decades. The goal of IGSS is to increase patient safety and improve workflow. We present an overview history IGSS, illustrate its current state, highlight future developments. Currently, requires image set, a tracking system, calibration method.Two-dimensional images have many disadvantages as source for navigation. most common navigation technique three-dimensional (3D) based on cross-sectional imaging techniques...
The two most dreaded complications of traumatic hyphema, secondary glaucoma and blood staining the cornea are much more likely to occur if there is further hemorrhage after initial bleeding episode. Hence, any means preventing this renewed would be a great boon ophthalmologist patient alike. In paper evidence presented that in conjugated estrogens we may have at our disposal such an agent. Rationale preparation estrogenic substances (Premarin)* I.V. was used first control uterine bleeding....
Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a highly reproducible procedure for the of spinal segments. We recently introduced concept "total navigation" to improve workflow and eliminate fluoroscopy. Imageguided surgery incorporating augmented reality (AR) may further facilitate workflow. In this study, we developed evaluated protocol integrate AR into MISTLIF.A case series 10 patients was basis evaluation tubular MIS-TLIF by application AR. Surgical TLIF...
Minimally invasive endoscope-assisted approaches to the anterior skull base offer an alternative traditional open craniotomies. Given restrictive operative corridor, appropriate case selection is critical for success. In this paper, authors present results of three different minimal access meningiomas and middle fossae examine differences in target areas considered each approach, as well outcomes, determine whether surgical goals were achieved.
Background: Mechanomyography (MMG) is a neurodiagnostic technique with documented ability to evaluate the compression of nerve roots. Its utility in degenerative spine surgery unknown. Objective: To assess intraoperative MMG during cervical posterior foraminotomy, minimally invasive transforaminal interbody fusion (MIS-TLIF), and tubular lumbar far lateral discectomy. Methods: A prospective feasibility study was conducted which applied three procedures. Adhesive accelerometers were placed on...
Surgical resection of benign intradural extramedullary tumors (BIETs) is effective for appropriately selected patients. Minimally invasive surgical (MIS) techniques have been described successful BIET while minimizing soft tissue injury. Augmented reality (AR) a promising new technology that can accurately allow intraoperative localization from skin through the compartment. We present case series evaluating timing, steps, and accuracy at which this able to enhance resection.A protocol MIS...
OBJECTIVE Cervical spondylotic myelopathy (CSM) can cause significant difficulty with driving and a subsequent reduction in an individual’s quality of life due to neurological deterioration. The positive impact surgery on postoperative patient-reported capabilities has been seldom explored. METHODS CSM module the Quality Outcomes Database was utilized. Patient-reported ability assessed via section Neck Disability Index (NDI) questionnaire. This is ordinal scale which 0 represents absence...
OBJECTIVE Telemedicine technology has been developed to allow surgeons in countries with limited resources access expert technical guidance during surgical procedures. The authors report their initial experience using state-of-the-art wearable smart glasses wireless capability transmit intraoperative video content spine surgery from sub-Saharan Africa experts the US. METHODS A novel system integrated camera and microphone was worn by a surgeon Dar es Salaam, Tanzania, 3 scoliosis correction...
Prospective observational study, level of evidence 1 for prognostic investigations.To evaluate the prevalence sleep impairment and predictors improved quality 24 months postoperatively in cervical spondylotic myelopathy (CSM) using outcomes database.Sleep disturbances are a common yet understudied symptom CSM.The database was queried patients with CSM, assessed through neck disability index component at baseline postoperatively. Multivariable logistic regressions were performed to identify...
Abstract Purpose: Fc-gamma receptors (FCGRs) are expressed on immune cells, bind to antibodies, and trigger antibody-induced cell-mediated antitumor responses when tumor-reactive antibodies present. The affinity of the FCGR/antibody interaction is variable dependent upon FCGR polymorphisms. Prior studies patients with cancer treated immunotherapy indicate that polymorphisms can influence response for certain immunotherapies act via therapeutically administered mAbs or endogenous induced from...
BACKGROUND: The management of spinal metastatic renal cell carcinoma (mRCC) is controversial regarding extent resection and radiation dosing. OBJECTIVE: To determine outcomes in patients treated with hybrid therapy (separation surgery plus adjuvant stereotactic body [SBRT]) for mRCC. METHODS: A retrospective study a prospectively collected cohort undergoing mRCC between 2003 2017 was performed. SBRT delivered as high-dose single-fraction, hypofractionated, or low-dose hypofractionated....