A5080039896- Reproductive Biology and Fertility
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Renal and related cancers
- Reproductive Health and Technologies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pregnancy and preeclampsia studies
- Dental Radiography and Imaging
- RNA Interference and Gene Delivery
- Birth, Development, and Health
- Viral Infections and Vectors
- Tissue Engineering and Regenerative Medicine
- Oral microbiology and periodontitis research
- Demographic Trends and Gender Preferences
- Sexual Differentiation and Disorders
- Evolutionary Psychology and Human Behavior
- Sperm and Testicular Function
University of Indonesia
2013-2025
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2013-2024
Eijkman Institute for Molecular Biology
2014
Chromosomal mosaicism, a phenomenon observed in minority of embryos, showcases its prevalence and inherent unpredictability, leading to variations embryo mosaic rates across different centers. This research endeavors assess the mosaicism characteristics within scope our preimplantation genetic testing-A (PGT-A) services Indonesia. Specifically focusing on center's experience since 2020, this study aims elucidate among embryos care. In retrospective approach, we collected secondary data...
Endometriosis is identified as presence of the endometrium outside uterine cavity. Retrograde menstruation contributes to endometrial tissue implantation and establishment endometriotic lesions at ectopic sites. It has been suggested that are rich in angiogenic growth factors, while they have an essential role survival invasion these cells. We investigated regulation microRNA-93 (miR-93) its involvement with vascular endothelial factor A (VEGFA) matrix metalloproteinase (MMP) 3 expression...
Embryo selection for in vitro fertilization (IVF) is an effort to increase the success rate of embryo implantation. Factors influencing implantation include quality, endometrial receptivity, characteristics, and maternal interactions. Some molecules have been found influence these factors, but their regulatory mechanisms are unclear. MicroRNAs (miRNAs) reported play essential role process. miRNAs small non-coding RNAs consisting only 20 nucleotides that stability gene expression regulation....
The dengue disease varies clinically from mild fever to hemorrhagic up potentially fatal shock syndrome.Such differences in manifestation of virus (DENV) infection have been ascribed intrinsic DENVs.Four DENV serotypes or four viruses (DENV-1 DENV-4) clearly distinguished; however, only limited information is available on their biological characteristics vitro.To shed more light this subject, replication kinetics all DENVs various cell lines and induction 26 cytokines/chemokines were...
Recently, as a delayed childbearing trend is emerging in modern women's adulthood, diminished reproductive potential due to age-related changes more prevalent. Reduction the abundance of mitochondrial DNA (mtDNA) copies and circulating anti-Müllerian hormone (AMH) have been separately reported with aging, contributing decrease successful reproduction. However, there are limited reports on impact age mtDNA AMH same individual whether copy numbers influenced by AMH. In present study, we...
Endometriosis affects women in many ways from infertility until reducing ovarian reserve. In who do not want to immediately conceive, ovarium cortex cryopreservation may be an option for preserving fertility.Two patients with chief complaints dysmenorrhea and abdominal enlargement, then checked Anti-Mullerian Hormone (AMH) level Ca-125 level. Patient underwent transrectal ultrasonography, the result of endometriosis cyst (sized 12 × 9x3 cm 7 10 11 first patient, while second patient had 18...
<ns3:p><ns3:bold>Background: </ns3:bold>This study was performed to evaluate the role of luteinizing hormone (LH) and granulosa cell LH receptor (LH-R) in poor responder patients who underwent controlled ovarian stimulation. Expression levels LH-R mRNA cells investigated compared with oocyte morphology, maturity fertilization rate. </ns3:p><ns3:p> <ns3:bold>Methods: </ns3:bold>Granulosa were obtained from 30 <ns3:italic>in vitro</ns3:italic> (IVF) at Dr. Cipto Mangunkusumo Hospital, Jakarta....
<ns3:p><ns3:bold>Background:</ns3:bold> Efforts in reproductive preservation for cancer patients have become one of the important aspects management. In fact, decline function is known to occur after exposure anti-cancer treatments. Measuring anti-Müllerian hormone (AMH) levels be best parameter predicting ovarian reserves, which indicates function. total, 68% survivors age who underwent treatments suffer from infertility. Meanwhile, reserves also decrease with increasing age. There ongoing...
<ns3:p><ns3:bold>Background:</ns3:bold> Efforts in reproductive preservation for cancer patients have become one of the important aspects management. In fact, decline function is known to occur after exposure anti-cancer treatments. Measuring anti-Müllerian hormone (AMH) levels be best parameter predicting ovarian reserves, which indicates function. total, 68% survivors age who underwent treatments suffer from infertility. Meanwhile, reserves also decrease with increasing age. There ongoing...
The lack of accuracy in embryo viability assessment methods still remains a challenge to increase the vitro fertilisation (IVF) success rate. chronological age and micro ribonucleic acid (RNA)-135b influence quality since microRNA-135b expresses stably spent culture media. Therefore, has potential become non-invasive biomarker IVF quality.(1) aim this study is determine expression distribution patients. (2) correlation between media patients.An observational was conducted Yasmin clinic.The...
This study aimed to measure the correlation between miR-183 and gene expression that regulates apoptosis adhesion mechanism may be linked pathogenesis of endometriosis.
During in vitro fertilization (IVF), not all patients receive good quality oocytes or embryos. This study investigated the frequency of aneuploidy and mosaicism embryos obtained from parthenogenetic poor morphological that also exhibited late cleavage development by preimplantation genetic screening (PGS). Twenty under IVF treatment were cultured until day 5, one blastomeres was biopsied. The divided into three groups (parthenogenetic poor-quality with dark cytoplasm, several vacuoles...
Women with poor ovarian response do not produce adequate follicles and express low estradiol levels after standard stimulation protocols; therefore, their chances of becoming pregnant are reduced. The follicle-stimulating hormone (FSH) binds to specific receptors (FSHRs) in the ovary, thereby activating adenylyl cyclase/cyclic adenosine monophosphate, a gene expression regulator. present study aimed evaluate whether FSHR responders differed from those normal responders. This cross-sectional...
Growth differentiation factor-9 (GDF9) and bone morphogenetic 15 (BMP15) are oocyte-secreted factors (OSF) that proteins members of the transforming growth factor β superfamily with roles in folliculogenesis to produce mature oocytes. GDF9 BMP15 candidates search for selective markers predict oocyte quality. Women endometriosis undergoing vitro fertilization (IVF) usually present reduced quality their The aim this study is examine expressions granulosa cells evaluate these patients. We...
Endometriosis may cause ovarian physiology disturbances and one of them, by affecting folliculogenesis that leads to a decreased oocyte quality. The plays an important role in regulating promoting follicle growth factors production. Several have been identified human oocytes, including differentiation factor-9 (GDF-9). However, studies on GDF-9 expression the granulosa cells infertile women with endometriosis are sparse. To investigate mRNA patients undergoing vitro fertilization (IVF)...
Endometriosis is a female reproductive disorder that can cause infertility by lowering oocyte quality due to low of oocytes. Granulosa cell assessment minimally invasive procedure for determining quality. Bone morphogenetic protein 15 (BMP15) also acts as growth factor derivatives regulate proliferation and granulosa differentiation. In endometriosis, higher BMP15 expression assumed induce growth. This study aimed determine the mRNA levels in cells from endometriosis patients undergoing...
<ns3:p><ns3:bold>Background:</ns3:bold> Endometriosis is one of the most common conditions causing infertility and an indication to undergo <ns3:italic>in vitro</ns3:italic> fertilization (IVF). High apoptosis rate oxidative stress in patients with endometriosis are believed negatively affect IVF success rate. However, there have been conflicting results on effect success, limited studies that directly assess its oocyte quality. This study was performed explore correlation between mRNA...
Anti-Mullerian Hormone (AMH) recently known as the most potential marker for ovarian reserve. Previous study by Wiweko, et al to 1616 subject proved that AMH can be used predict female biological age earlier than Follicle Stimulating (FSH) and Antral Count (AFC). Normogram from is programmed Android based application "Indonesian Kalkulator of Oocytes (IKO)" which has been widely help physician give information about reserve patient. In this study, we aimed validate use IKO in daily practice...
Embryo spent culture medium has been intensively investigated, considering its promising feature for non-invasive bioanalytical techniques in in-vitro fertilization (IVF). Despite, isolating DNA from such samples is quite challenging due to small volume. Carrier RNA reported exhibit retrieval effects and commonly employed various limited biological samples, but there are no reports regarding benefit on embryo media. Therefore, we aim evaluate the competence of cRNA isolated analyzed optimal...