A5008719719- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
University Medical Center Utrecht
2020-2024
Utrecht University
2020-2024
Oncode Institute
2020-2024
Collagens are a primary component of the extracellular matrix and functional ligands for inhibitory immune receptor leukocyte-associated immunoglobulin-like (LAIR)-1. LAIR-2 is secreted protein that can act as decoy by binding collagen with higher affinity than LAIR-1. We propose collagens promote evasion interacting LAIR-1 expressed on cells, releases LAIR-1-mediated suppression. Analysis public human datasets shows collagens, have unique overlapping associations survival in certain tumors....
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, extracellular matrix (ECM). During development, ECM homeostasis dysregulated. Collagen remodeling by metalloproteinases (MMPs) generates specific collagen fragments, that can be detected in the circulation cancer patients correlate with poor disease outcome. Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) an inhibitory receptor expressed on cells TME circulation. We...
Abstract Collagen expression and structure in the tumour microenvironment are associated with development therapy response. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a widely expressed inhibitory collagen receptor. LAIR-2 soluble homologue of LAIR-1 that competes for binding. Multiple studies mice implicate blockade LAIR-1:collagen interaction cancer as promising therapeutic strategy. Here, we investigated role anti-tumour responses. We show although inhibits...
Despite major successes with inhibitory receptor blockade in cancer, the identification of novel receptors as putative drug targets is needed due to lack durable responses, therapy resistance, and side effects. Most signal via immunoreceptor tyrosine-based motifs (ITIMs) previous studies estimated that our genome contains over 1600 ITIM-bearing transmembrane proteins. However, testing development these candidates requires increased understanding their expression patterns likelihood function...
Despite major successes with inhibitory receptor blockade in cancer, the identification of novel receptors as putative drug targets is needed due to lack durable responses, therapy resistance, and side effects. Most signal via immunoreceptor tyrosine-based motifs (ITIMs) previous studies estimated that our genome contains over 1600 ITIM-bearing transmembrane proteins. However, testing development these candidates requires increased understanding their expression patterns likelihood function...
Blocking inhibitory receptors like PD-1 and CTLA-4 has revolutionized cancer treatment in recent years. However, despite major successes melanoma lung cancer, the majority of types are not responsive to these immunotherapies. As such, there is an ongoing need for identification novel as drug targets. Most signal via immunoreceptor tyrosine-based motifs (ITIMs) previous studies have estimated that our genome contains over 1600 ITIM-bearing transmembrane proteins. further testing development...
Blocking inhibitory receptors like PD-1 and CTLA-4 has revolutionized cancer treatment in recent years. However, despite major successes melanoma lung cancer, the majority of types are not responsive to these immunotherapies. As such, there is an ongoing need for identification novel as drug targets. Most signal via immunoreceptor tyrosine-based motifs (ITIMs) previous studies have estimated that our genome contains over 1600 ITIM- bearing transmembrane proteins. further testing development...
Abstract Collagens are a primary component of the extracellular matrix and functional ligands for inhibitory immune receptor leukocyte associated immunoglobulin-like receptor-1 (LAIR-1). Leukocyte receptor-2 (LAIR-2) is secreted protein that can act as decoy by binding collagen with higher affinity than LAIR-1. We propose collagens promote evasion interacting LAIR-1 LAIR-2 could release mediated suppression. Analysis public datasets shows high expression being favorable outcome in certain...
Abstract Blocking inhibitory receptors like PD-1 and CTLA-4 has revolutionized cancer treatment in recent years. However, despite major successes melanoma lung cancer, the majority of types are not responsive to these immunotherapies. As such, there is an ongoing need for identification novel as drug targets. Most signal via immunoreceptor tyrosine-based motifs (ITIMs) previous studies have estimated that our genome contains over 1600 ITIM- bearing transmembrane proteins. further testing...