A5064335398- Rheumatoid Arthritis Research and Therapies
- Chronic Disease Management Strategies
- Neonatal Respiratory Health Research
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Frailty in Older Adults
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Enzyme Production and Characterization
- Protease and Inhibitor Mechanisms
- Inflammatory Bowel Disease
- Immune cells in cancer
- Biosimilars and Bioanalytical Methods
- Metabolomics and Mass Spectrometry Studies
- Spondyloarthritis Studies and Treatments
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- Healthcare cost, quality, practices
- Porphyrin Metabolism and Disorders
- Myofascial pain diagnosis and treatment
- Genomics and Rare Diseases
University of Glasgow
2016-2025
Centre for Immunity, Infection and Evolution
2023
Versus Arthritis
2021
Wellcome Sanger Institute
2005-2007
Wellcome Trust
2007
Institut Pasteur
2005
Centre National de la Recherche Scientifique
2005
International Livestock Research Institute
2005
Louisiana State University
1970
Peptidases (proteolytic enzymes or proteases), their substrates and inhibitors are of great relevance to biology, medicine biotechnology. The MEROPS database ( http://merops.sanger.ac.uk ) aims fulfil the need for an integrated source information about these. organizational principle is a hierarchical classification in which homologous sets peptidases protein grouped into species, families turn clans. Important additions include newly written, concise text annotations peptidase clans small...
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome compared it with to understand mechanisms underlying transformation tropism. Despite high conservation gene sequences synteny, analysis reveals unequally expanded families species-specific genes. also identify divergent putative secreted polypeptides may reduce immune recognition, candidate regulators host-cell transformation, a Theileria-specific...
Bacterial cell characteristics change significantly during differentiation between planktonic and biofilm states. While established methods exist to detect identify transcriptional proteomic changes, metabolic fluctuations that distinguish these developmental stages have been less amenable investigation. The objectives of the study were develop a robust reproducible sample preparation methodology for high throughput analysis determine differences Staphylococcus aureus in method uses bead...
The Polyomics integrated Metabolomics Pipeline (PiMP) fulfils an unmet need in metabolomics data analysis. PiMP offers automated and user-friendly analysis from mass spectrometry acquisition to biological interpretation. Our key innovations are the Summary Page, which provides a simple overview of experiment format scientific paper, containing findings along with associated metadata; Metabolite list each metabolite accompanied by 'evidence cards', provide variety criteria behind annotation...
Abstract To understand the contribution of mononuclear phagocytes (MNP), which include monocyte-derived intestinal macrophages, to pathogenesis inflammatory bowel disease (IBD), it is necessary identify functionally-different MNP populations. We aimed characterise macrophage populations in patients with IBD. developed 12-parameter flow cytometry protocols and human MNPs. used these purify characterize colonic macrophages from tissue Crohn’s (CD), ulcerative colitis (UC), or non-inflamed...
Objective To assess the prevalence of frailty in rheumatoid arthritis (RA) and its association with baseline longitudinal disease activity, all-cause mortality hospitalisation. Participants People RA identified from Scottish Early Rheumatoid Arthritis (SERA) inception cohort (newly diagnosed, mean age 58.2 years) UK Biobank (established using diagnostic codes, 59 years). Frailty was quantified index (both datasets) phenotype (UK only). Disease activity assessed Activity Score 28 joints...
ABSTRACT Background Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights can inform clinical decisions. However, despite its potential, gene remains challenging clinicians due to specialised skills required access, integrate, and analyse large datasets. Existing tools primarily focus on RNA-Seq data analysis, providing user-friendly interfaces but often falling short in several critical...
Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies against modified proteins, known as anti-modified protein (AMPAs). While relationship between different AMPA isotypes and various risk factors remains poorly understood, investigating this association important for a deeper understanding RA pathophysiology. Smoking, has its primary effects in lungs, it unclear whether smoking preferentially linked to specific isotypes, such...
Abstract Background Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights can inform clinical decisions. However, despite its potential, gene remains challenging clinicians due to specialised skills required access, integrate, and analyse large datasets. Existing tools primarily focus on RNA-Seq data analysis, providing user-friendly interfaces but often falling short in several critical...
Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently identified lysosomal cysteine protease belonging to clan CD. To date it has been shown be involved in antigen presentation within class II MHC positive cells and pro-protein processing. Further elucidation of the biological functions enzyme will require potent selective inhibitors thus we describe here new acyloxymethylketone AEP. The most series 2,6-dimethyl-benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl...
Campylobacter jejuni is the leading cause of foodborne bacterial enteritis in humans, and yet little known regard to how genetic diversity metabolic capabilities among isolates affect their phenotype pathogenicity. For instance, C. 11168 strain can utilize both l-fucose l-glutamate as a carbon source, which provides with competitive advantage some environments this study we set out assess response presence growth medium. To achieve this, untargeted hydrophilic liquid chromatography coupled...
We aimed to classify individuals with RA and ≥2 additional long-term conditions (LTCs) describe the association between different LTC classes, number of LTCs adverse health outcomes.We used UK Biobank participants who reported (n=5,625) employed latent class analysis (LCA) create classes combinations for those LTCs. Cox-proportional hazard negative binomial regression were compare risk all-cause mortality, major cardiac events (MACE), emergency hospitalisations over an 11-year follow-up...
Memory T cells respond rapidly in part because they are less reliant on a heightened levels of costimulatory molecules. This enables rapid control secondary infecting pathogens but presents challenges to efforts or silence memory CD4 cells, for example antigen-specific tolerance strategies autoimmunity. We have examined the transcriptional and functional consequences reactivating absence an adjuvant. find that generated by infection immunisation survive activation with antigen delivered...
To investigate association between presence of multimorbidity in people with established and early rheumatoid arthritis (RA) risk, duration cause hospitalisations.Longitudinal observational study.UK Biobank, population-based cohort recruited 2006 2010, the Scottish Early Rheumatoid Arthritis (SERA), inception 2011 2015. Both linked to mortality hospitalisation data.4757 UK Biobank participants self-reporting RA; 825 SERA RA meeting 2010 ACR/EULAR classification criteria. Participants...
ObjectiveRheumatoid arthritis (RA) develops after progressing through sequential 'pre-RA' phases. The mechanisms driving progression from one phase to the next remain poorly understood. This study examined longitudinal rates of community and hospital infections in patients during stages pre-RA early arthritis.The Scottish Early RA inception cohort recruited with newly diagnosed RA. Incidences infection were determined antibiotic prescriptions serious by discharge coding. Dates diagnosis...
<h3>Background:</h3> Studying which biological pathways are involved in reaching remission auto-immune diseases could highlight possible targetable mechanisms. Rheumatoid arthritis (RA) is the ideal model disease to study this hypothesis due well-defined and widely-used measures of activity. <h3>Objectives:</h3> To increase understanding mechanisms underlying autoimmune through GWAS directed functional studies. <h3>Methods:</h3> The RTCure network collected genetic data 5,622 deeply...
Abstract Lung structural cells, including epithelial cells and fibroblasts, form barriers against pathogens trigger immune responses following infections such as influenza A virus. This response leads to the recruitment of innate adaptive required for viral clearance. Some these recruited remain within lung infection contribute enhanced control subsequent infections. There is growing evidence that can also display long-term changes or insults. Here we investigate mouse endothelial virus find...