A5048962942- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Thermal Regulation in Medicine
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Machine Learning in Healthcare
- Peripheral Neuropathies and Disorders
- Transplantation: Methods and Outcomes
- Electronic Health Records Systems
- SARS-CoV-2 detection and testing
- Fibromyalgia and Chronic Fatigue Syndrome Research
- vaccines and immunoinformatics approaches
- Autoimmune and Inflammatory Disorders Research
- Intensive Care Unit Cognitive Disorders
- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Evolution and Genetic Dynamics
- Colorectal Cancer Treatments and Studies
- Neuroinflammation and Neurodegeneration Mechanisms
Vere Software (United States)
2021-2025
Duke University
2021
University of Alabama at Birmingham
2021
Sage Bionetworks
2021
<h3>Importance</h3> Persons with immune dysfunction have a higher risk for severe COVID-19 outcomes. However, these patients were largely excluded from SARS-CoV-2 vaccine clinical trials, creating large evidence gap. <h3>Objective</h3> To identify the incidence rate and ratio (IRR) breakthrough infection after vaccination among persons or without dysfunction. <h3>Design, Setting, Participants</h3> This retrospective cohort study analyzed data National COVID Cohort Collaborative (N3C),...
Variation in risk of adverse clinical outcomes patients with cancer and COVID-19 has been reported from relatively small cohorts. The NCATS' National COVID Cohort Collaborative (N3C) is a centralized data resource representing the largest multicenter cohort cases controls nationwide. We aimed to construct characterize within N3C identify factors for all-cause mortality COVID-19.
To provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort cases controls.
The integration of diverse clinical data sources requires standardization through models like OMOP (Observational Medical Outcomes Partnership). However, mapping elements to concepts demands significant technical expertise and time. While large healthcare systems often have resources for conversion, smaller trials studies frequently lack such support, leaving valuable research siloed. To develop validate a user-friendly tool that leverages language automate the conversion process trial,...
Background. Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality solid organ transplant (SOT) recipients. The National COVID Cohort Collaborative was developed to facilitate analysis of patient-level data for those tested COVID-19 across the United States. Methods. In this study, we identified a cohort SOT recipients testing positive or negative (COVID+ COVID−, respectively) between January 1, 2020, November 20, 2020. Univariable multivariable logistic...
ABSTRACT Background Individuals with immune dysfunction, including people HIV (PWH) or solid organ transplant recipients (SOT), might have worse outcomes from COVID-19. We compared odds of COVID-19 between patients and without dysfunction. Methods evaluated data the National Cohort Collaborative (N3C), a multicenter retrospective cohort electronic medical record (EMR) across United States, on. 1,446,913 adult laboratory-confirmed SARS-CoV-2 infection. HIV, SOT, comorbidity, markers were...
Relatively little is known about the use patterns of potential pharmacologic treatments COVID-19 in United States.To National COVID Cohort Collaborative (N3C), a large, multicenter, longitudinal cohort, to characterize hydroxychloroquine, remdesivir, and dexamethasone, overall as well across individuals, health systems, time.Retrospective cohort study.43 systems States.137 870 adults hospitalized with between 1 February 2020 28 2021.Inpatient or dexamethasone.Among 137 persons confirmed...
While older males are at the highest risk for poor coronavirus disease 2019 (COVID-19) outcomes, it is not known if this applies to immunosuppressed recipient of a solid organ transplant (SOT), nor how type allograft transplanted may impact outcomes. In cohort study adult (>18 years) patients testing positive COVID-19 (January 1, 2020-June 21, 2021) from 56 sites across United States identified using National COVID Cohort Collaborative (N3C) Enclave, we used multivariable Cox proportional...
Objective This study aimed to compare COVID-19 positivity by HIV status and race/ethnicity using data from the U.S. National COVID Cohort Collaborative (N3C). Methods The N3C cohort (≥ 18 years) includes patients with any encounter after 1/1/2020 SARS-CoV-2 laboratory tests. Detailed electronic medical records are centralized harmonized across health-care organizations (34 sites). diagnosis was defined RT-PCR or antibody testing. infection standard diagnostic codes within 2 years prior...
Abstract Patients with multiple myeloma (MM), an age-dependent neoplasm of antibody-producing plasma cells, have compromised immune systems and might be at increased risk for severe COVID-19 outcomes. This study characterizes factors associated clinical indicators severity all-cause mortality in patients utilizing NCATS’ National COVID Cohort Collaborative (N3C) database. The N3C consortium is a large, centralized data resource representing the largest multi-center cohort cases controls...
While coronavirus disease 2019 (COVID-19) is no longer a public health emergency, certain patients remain at risk of severe outcomes. To better understand changing profiles, we studied the factors for with and without solid organ transplantation (SOT) through various waves pandemic.
ABSTRACT Summary Mutation is the key for a variant of concern (VOC) to overcome selective pressures, but this process still unclear. Understanding association mutational with VOCs an unmet need. Motivation: Here, we developed VOC-alarm, method predict and their caused COVID surges, using mutations about 5.7 million SARS-CoV-2 complete sequences. We found that rely on lineage-level entropy value mutation numbers compete other variants, suggestive importance population-level in virus...
ABSTRACT Importance Since late 2019, the novel coronavirus SARS-CoV-2 has given rise to a global pandemic and introduced many health challenges with economic, social, political consequences. In addition complex acute presentation that can affect multiple organ systems, there is mounting evidence of various persistent long-term sequelae. The worldwide scientific community characterizing diverse range seemingly common outcomes associated infection, but underlying assumptions in these studies...
Background: Individuals with immune dysfunction, including people HIV (PWH) or solid organ transplant recipients (SOT), might have worse outcomes from COVID-19. We compared odds of COVID-19 between patients and without dysfunction.Methods: evaluated data the National Cohort Collaborative (N3C), a multicenter retrospective cohort electronic medical record (EMR) across United States, on. 1,446,913 adult laboratory-confirmed SARS-CoV-2 infection. HIV, SOT, comorbidity, markers were identified...
1540 Background: Post-acute sequelae of SARS-CoV-2 or long COVID, is characterized by persistence symptoms and/or emergence new post COVID-19 infection. As evidence accumulates and national initiatives arise to address this increasingly prevalent syndrome, characterization specific patient groups still lacking including patients with cancer. Using a nationally representative sample over 4.3M from the National COVID Cohort Collaborative (N3C), we aim describe characteristics cancer COVID....
1500 Background: The impact of COVID-19 has disproportionately affected every aspect cancer care and research—from introducing new risks for patients to disrupting the delivery treatment continuity research. Variation in risk adverse clinical outcomes by type been reported from relatively small cohorts. Gaps understanding effects on can be addressed through study a well-constructed representative cohort. NCATS’ National COVID Cohort Collaborative (N3C) is centralized data resource...
ABSTRACT Background Effects of timing Convalescent plasma (CP) administration on hospitalized COVID-19 patients are not established. Methods We used the National COVID Cohort Collaborative data to perform a retrospective cohort study in United States between 07-01-2020 and 12-19-2020. stratified based day CP (Day 0, 1, 2, 3 4) from diagnosis. 35 predictors frame matched cohorts accounting for clinical sociodemographic characteristics. competing risk survival models examine association length...
e24142 Background: The survival benefits and the risks of severe immune-related adverse events (sirAEs) Immune checkpoint inhibitors (ICI) vary dramatically among cancer patients. Among sirAEs, acute kidney injury (AKI) incidences are rising, often cause sustained renal damage, responsible for deterioration patients’ overall health quality life. There is an urgent need to support oncologists nephrologists in choosing right ICI drugs We aim comprehensively scrutinize tradeoff between AKI risk...
<sec> <title>BACKGROUND</title> The integration of diverse clinical data sources requires standardization through models such as Observational Medical Outcomes Partnership (OMOP). However, mapping elements to OMOP concepts demands significant technical expertise and time. While large health care systems often have resources for conversion, smaller trials studies frequently lack support, leaving valuable research siloed. </sec> <title>OBJECTIVE</title> This study aims develop validate a...
e18672 Background: Comprehensive real-world evidence of the virulence COVID-19 Omicron, Delta, and Alpha variants as well effectiveness booster vaccinations in patients with cancer are lacking. We aimed to fill these gaps for provide essential insights on management fast-evolving pandemic by leveraging nationally-representative electronic medical records from National COVID Cohort Collaborative (N3C) registry. Methods: The was examined according severe outcomes infected cancer, compared...