A5090929397- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
- Neuroscience of respiration and sleep
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Diabetes Treatment and Management
- Ion channel regulation and function
- Effects of Environmental Stressors on Livestock
- Diet and metabolism studies
- Cancer-related cognitive impairment studies
- Reproductive Physiology in Livestock
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Infant Health and Development
- Cardiac Ischemia and Reperfusion
- Muscle Physiology and Disorders
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Advanced Breast Cancer Therapies
Fukushima Medical University
2016-2025
University of Oxford
2024
Hokkaido University of Science
2022
Fukushima University
2022
University of Shizuoka
2020
Kobe University
2020
Jichi Medical University
2007-2018
Andalas University
2015
Utsunomiya University
2003-2009
Tokyo University of Agriculture and Technology
2005-2008
Nesfatin-1, a newly discovered satiety molecule, is located in the hypothalamic nuclei, including paraventricular nucleus (PVN) and supraoptic (SON). In this study, fine localization regulation of nesfatin-1 neurons PVN SON were investigated by immunohistochemistry neuropeptides c-Fos. PVN, 24% overlapped with oxytocin, 18% vasopressin, 13% CRH, 12% TRH neurons. SON, 35% oxytocin 28% vasopressin. After 48-h fast, refeeding for 2 h dramatically increased number expressing c-Fos...
Recent studies suggest that oxytocin (Oxt) is implicated in energy metabolism. We aimed to explore acute and sub-chronic effects of peripheral Oxt treatment via different routes on food intake balance. Intraperitoneal (ip) injection concentration-dependently decreased mice. Ip induced c-Fos expression the hypothalamus brain stem including arcuate nucleus (ARC), paraventricular (PVN) tractus solitarius (NTS). Subcutaneous (sc) suppressed normal high fat diet-induced obese (DIO) Daily sc for...
Oxytocin (Oxt), a neuropeptide produced in the hypothalamus, is implicated regulation of feeding. Recent studies have shown that peripheral administration Oxt suppresses feeding and, when infused subchronically, ameliorates hyperphagic obesity. However, route through which informs brain obscure. This study aimed to explore whether vagal afferents mediate sensing and anorexigenic effect peripherally injected mice. Intraperitoneal injection suppressed food intake increased c-Fos expression...
Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological distress, this a major source of increased morbidity mortality in cancer patients. This study aimed to clarify the gut–brain peptides involved pathogenesis determine effective treatment for anorexia–cachexia. We show that both ghrelin insufficiency resistance were observed tumor-bearing rats. Corticotropin-releasing factor (CRF) plasma level acyl ghrelin, its...
Aging | doi:10.18632/aging.100207. Natsu Yoshida, Yuko Maejima, Udval Sedbazar, Akihiko Ando, Hideharu Kurita, Boldbaatar Damdindorj, Eisuke Takano, Darambazar Gantulga, Yusaku Iwasaki, Tomoyuki Kurashina, Tatsushi Onaka, Katsuya Dezaki, Masanori Nakata, Masatomo Mori, Toshihiko Yada
Abstract Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or various endogenous diseases related to bacterial translocation from the gut. Systemic inflammatory responses induced by endotoxemia induce severe involuntary loss of skeletal muscle, termed muscle wasting, which adversely affects survival and functional outcomes these patients. Currently, no drugs available for treatment endotoxemia-induced wasting. Here, we tested effects TAK-242, a...
The aim of the present study is to investigate effects canagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, on non-alcoholic steatohepatitis (NASH) and NASH-related hepatocellular carcinoma (HCC) in mouse model diabetes NASH-HCC. First, mice aged five weeks were divided into two groups (vehicle group canagliflozin group) treated for three weeks. Then, nine animals each: vehicle group, early (treated from weeks), continuous 16 weeks). Canagliflozin was administered at...
Soluble dipeptidyl peptidase-4 (sDPP-4) is secreted by hepatocytes and induces adipose tissue inflammation insulin resistance. Sodium-glucose co-transporter-2 (SGLT2) inhibitors can improve hepatic steatosis inhibiting de novo lipogenesis. We investigated the effects of dapagliflozin (an SGLT2 inhibitor) on serum levels sDPP-4 in patients with type 2 diabetes non-alcoholic fatty liver disease (NAFLD).Fifty-seven NAFLD were randomized to a group (5 mg/d for 24 weeks) (n = 33) or control 24)....
By restoring glucose-regulated insulin secretion, glucagon-like peptide-1–based (GLP-1–based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose levels by stimulation of secretion pancreatic β cells. However, reason why only GLP-1–based drugs effective improving after presentation has not been resolved. ATP-sensitive K+ (KATP) channels play a crucial role...
Abstract The intricate link between glucose metabolism, ATP production, and glucose‐stimulated insulin secretion (GIIS) in pancreatic β‐cells has been well established. However, the effects of other digestible monosaccharides on this mechanism remain unclear. This study examined interaction intracellular fructose metabolism GIIS using MIN6‐K8 β‐cell lines mouse islets. Fructose at millimolar concentrations potentiated presence stimulatory levels (8.8 mM) glucose. potentiation was dependent...
Neuropeptide Y (NPY) neurons in the hypothalamic arcuate nucleus (ARC) play a central role stimulation of feeding. They sense and integrate peripheral signals, including ghrelin leptin. However, mechanisms interaction these hormones NPY are largely unknown. This study explored underlying signaling cross talk between leptin neurons. Cytosolic Ca(2+) concentration ([Ca(2+)](i)) single isolated from ARC adult rats was measured by fura-2 microfluorometry. Ghrelin increased [Ca(2+)](i) 31% The...
Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), melanocortin‐dependently suppresses feeding. However, the underlying neuronal pathway is unclear. This study aimed to determine whether Oxt regulates propiomelanocortin (POMC) neurons arcuate nucleus (ARC) hypothalamus. Intra‐ARC decreased food intake. increased cytosolic Ca 2+ POMC isolated from ARC. ARC expressed receptors were contacted by...
Learning processes contributing to appropriate selection and flexible switching of behaviors are mediated through the dorsal striatum, a key structure basal ganglia circuit. The major inputs striatal subdivisions provided from intralaminar thalamic nuclei, including central lateral nucleus (CL) parafascicular (PF). Thalamostriatal neurons in PF modulate acquisition performance stimulus-response learning. Here, we address roles CL thalamostriatal learning by using selective neural pathway...
Recent studies have considered oxytocin (Oxt) as a possible medicine to treat obesity and hyperphagia. To find the effective safe route for Oxt treatment, we compared effects of its nasal intraperitoneal (IP) administration on food intake, locomotor activity, glucose tolerance in mice. Nasal decreased intake without altering activity increased number c-Fos-immunoreactive (ir) neurons paraventricular nucleus (PVN) hypothalamus, area postrema (AP), dorsal motor vagus (DMNV) medulla. IP...
Food selection is essential for metabolic homeostasis and influenced by nutritional state, food palatability, social factors such as stress. However, the mechanism responsible between a high-carbohydrate diet (HCD) high-fat (HFD) remains unknown. Here, we show that activation of subset corticotropin-releasing hormone (CRH)-positive neurons in rostral region paraventricular hypothalamus (PVH) induces an HCD over HFD mice during refeeding after fasting, resulting rapid recovery from change...
Brain-derived neurotrophic factor (BDNF) has been implicated in learning, depression and energy metabolism. However, the neuronal mechanisms underlying effects of BDNF on metabolism remain unclear. The present study aimed to elucidate pathways by which controls feeding behaviour balance. Using an osmotic mini-pump, or control artificial cerebrospinal fluid was infused i.c.v. at lateral ventricle into paraventricular nucleus hypothalamus (PVN) for 12 days. Intracerebroventricular up-regulated...
Abstract Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome atherosclerosis. Accumulating evidence suggest that adiponectin acts on the brain including hypothalamic arcuate nucleus (ARC), where proopiomelanocortin (POMC) neurons play key roles in feeding regulation. Several studies have examined intracerebroventricular (ICV) injection of reported opposite effects, increase or decrease food intake. These reports used different nutritional states. The present...
Abstract Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) an anti-obesity peptide, there no comparative study its effect This aims to determine factors (sex, initial body weight, fat distribution) that may affect ability Oxt regulate weight (BW). With regard sex, reduced BW similarly females under high diet (HFD) standard chow-fed condition. The reduction induced by correlated with male female...
Abstract Sildenafil, a phosphodiesterase‐5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated. This study examines the impact of sildenafil on secretion MIN6‐K8 mouse clonal β cells. Sildenafil amplified by enhancing Ca 2+ influx. These required depolarizing stimuli cells but not K ATP channel‐deficient cells, which were already depolarized, indicating that...
GLP-1 receptor agonists are the number one drug prescribed for treatment of obesity and type 2 diabetes. These drugs not, however, without side effects, in an effort to maximize therapeutic effect while minimizing adverse gut hormone co-agonists received considerable attention as new targets fight against obesity. Numerous previous reports identified neuropeptide oxytocin (OXT) a promising anti-obesity drug. The aims this study were evaluate OXT possible co-agonist examine effects its...
ELABELA (ELA) is a novel hormone consisting of 32 amino acid peptides found in humans as well other vertebrates and considered to play an important role the circulatory system through apelin receptor (APJ). However, whether ELA also acts central nervous remains unknown. Here, we show that functions anorexigenic adult mouse brain. An intracerebroventricular injection reduces food intake activates arginine vasopressin (AVP) corticotropin-releasing (CRH) neurons paraventricular nucleus (PVN),...
Abstract Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used to treat type 2 diabetes, reduce blood pressure (BP) in hypertensive patients. Whether this action involves central mechanisms is unknown. We here report that repeated lateral ventricular (LV) injection of GLP-1R agonist, liraglutide, once daily for 15 days counteracted the development hypertension spontaneously rats (SHR). In parallel, it suppressed urinary norepinephrine excretion, and induced c-Fos expressions area...