A5101691387- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Plant Disease Management Techniques
- Probiotics and Fermented Foods
- Postharvest Quality and Shelf Life Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Pathogens and Fungal Diseases
- Heavy metals in environment
- Heme Oxygenase-1 and Carbon Monoxide
- Arsenic contamination and mitigation
- Gut microbiota and health
- Proteins in Food Systems
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Seaweed-derived Bioactive Compounds
- Traditional Chinese Medicine Analysis
- Curcumin's Biomedical Applications
- Coal and Its By-products
- Mercury impact and mitigation studies
Beijing Union University
2013-2025
Donghua University
2024
Soochow University
2011
Probiotics, recognized as beneficial and active microorganisms, often face challenges in maintaining their functionality under harsh conditions such exposure to stomach acid bile salts. In this investigation, we developed probiotic microcapsules assessed protective effects underlying mechanisms a murine model of dextran sulfate sodium (DSS)-induced colitis using male C57BL/6J mice. The administration the significantly mitigated body weight loss, prevented colon length shortening, decreased...
Alzheimer's disease (AD) is a neurodegenerative disorder that damages health and welfare of the elderly, there has been no effective therapy for AD until now. It proved tanshinone IIA (tan IIA) could alleviate pathological symptoms via improving non-amyloidogenic cleavage amyloid precursor protein, decreasing accumulations p-tau amyloid-β1-42 (Aβ1-42), so forth. However, further biochemical mechanisms tan are not clear. The experiment was undertaken to explore metabolites in rats induced by...
Alzheimer’s disease (AD) is characterized by the abnormal aggregation of amyloid-β peptide (Aβ) in extracellular deposits known as senile plaques. The tyrosine residue (Tyr-10) believed to be important Aβ-induced neurotoxicity due formation tyrosyl radicals. To reduce likelihood cross-linking, here we designed an Aβ-40 analogue (Aβ-40 Y10F) which was substituted a structurally similar residue, phenylalanine. rate determined Thioflavin T (ThT) assay, Y10F populated ensemble folded...
Alzheimer's disease (AD) is a neurodegenerative disorder with insidious onset and progressive development. There an urgent need to find drugs that prevent slow AD progression. We focus our attention on 3,6'-disinapoyl sucrose (DISS), oligosaccharide antidepressant antioxidant activities. In this work, APP/PS1 transgenic mice were used explore the neuroprotective impact of DISS provide new applications for prevention therapy AD. This study aims assess DISS's learning memory deficits in using...
A comprehensive evaluation of the chemical forms heavy metals, rather than their total amount elements, is basis scientific and objective safety in metals. As mercury, most toxic metal environment (such as water, soil, air), accumulates medicinal plants, mercury plants preparation need to be clearly understood. This study aims summarize status bulk Chinese herbs traditional medicine preparations discuss research methods for analysis. Further, widespread high-performance liquid...
The newly designed butterfly-shaped hetero-tetranuclear CuII-NaI coordination compound, [Cu3(HL)2Na]∙Pic (Pic− is abbreviation of picrate) (1) which derived from a naphthalenediol-based bis(Salamo)-type chelating ligand H4L have been synthesized and characterized by elemental analyses, UV-vis spectra, IR spectra analysis, Hirshfeld surface analysis. X-ray crystallographic analyses revealed that the compound 1 novel it differs heterotrinuclear reported earlier. Cu1 Cu3 atoms are...
Alzheimer's disease (AD) is a degenerative of the central nervous system characterized by progressive impairment neural activity. Studies have shown that 3,6'-disinapoyl sucrose (DISS) can alleviate pathological symptoms AD through activation cAMP/CREB/BDNF signaling pathway. However, exact biochemical mechanisms action DISS are not clear. This study explores metabolism in an mouse model, induced microinjection lentiviral expression plasmid APPswe695 gene into CA1 hippocampus. After gavage...
Alzheimer’s disease (AD) is a common neurological in the elderly, and major manifestations are cognitive dysfunction, neuronal loss, neuropathic lesions brain. In process of AD pathogenesis, inflammatory response plays an indispensable role. The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin containing 3 (NLRP3) inflammasome NOD, leucine-rich repeat (LRR), pyran domains multi-molecular complex that can detect dangerous signals related to diseases. assembly NLRP3...
Abstract The absorption, distribution, and transport trends of organic inorganic arsenic (As) in honesuckle ( Lonicera japonica ) were studied using synchrotron X-ray fluorescence spectroscopy (μ-XRF). root, stem, leaf samples analyzed by μ-XRF, proving that the presence dimethyl arsenate acid, a small amount As accumulated local areas epidermis cortex roots, while most migrated to upper plant through middle vascular column. After reaching was mainly distributed outer skin, indicating root...
The aim of this study is to explore the effect and mechanism 3,6'-disinapoylsucrose (DISS) on an Alzheimer's disease (AD) mice model induced by APPswe695 lentivirus (LV) intraperitoneal injection lipopolysaccharide (LPS). results show that DISS improves cognitive ability, decreases levels IL-2, IL-6, IL-1β, TNF-α, reduces expression NF-κB p65, alleviates Aβ deposition nerve cell damage. can regulate tyrosine kinase B (TrkB)/brain-derived neurotrophic factor (BDNF) signaling in hippocampus....
Lead anode slime is produced in large quantities during lead electrolysis, which has a high Sb content of 10-50 wt% and can be easily recycled. However, general alkaline pressure leaching process for pre-removal As, was partially converted to Na3SbO4 with stability. This limited the reduction recovery subsequent Na2CO3 smelting reduction. Considering this fact, ZnS creatively used as an additive study destroy stable structure increase reduction, meanwhile reduced volatile Zn (g) In certain...