A5054505561- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Statistical Methods and Bayesian Inference
- RNA Research and Splicing
- Electrocatalysts for Energy Conversion
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
- Electrochemical Analysis and Applications
- Statistical Methods in Clinical Trials
- Prostate Cancer Treatment and Research
- CRISPR and Genetic Engineering
- Advanced battery technologies research
- Statistical Methods and Inference
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Chalcogenide Semiconductor Thin Films
- Genetic Syndromes and Imprinting
- Work-Family Balance Challenges
- Skin and Cellular Biology Research
- Lung Cancer Research Studies
- Seaweed-derived Bioactive Compounds
- Plant Molecular Biology Research
- Advanced Causal Inference Techniques
Guardant (United States)
2023-2025
Beijing Union University
2025
Soochow University
2023-2025
Broad Center
2015-2024
University of Southern California
2015-2024
Southwest Medical University
2023
Macau University of Science and Technology
2023
Chinese University of Hong Kong
2022
General Department of Preventive Medicine
2016
Beijing Technology and Business University
2006
In the volatile, uncertain, complex, and ambiguous environment (VUCA), employees can better match organization jobs by crafting their job perceptions, work tasks, relationships, which is valuable to maintain organizational sustainable competitiveness promote employees' personal growth. This study explores influence mechanisms of autonomy meaning on job-crafting behaviors moderating effect perceived change through a survey 318 in Chinese companies. The results show that increasing...
Kruppel-like factor 4 (Klf4) is a zinc-finger-containing protein that plays critical role in diverse cellular physiology. While most of these functions attribute to its as transcription factor, it postulated Klf4 may play other than transcriptional regulation. Here we demonstrate loss neural progenitor cells (NPCs) leads increased neurogenesis and reduced self-renewal mice. In addition, interacts with RNA-binding Staufen1 (Stau1) RNA helicase Ddx5/17. They function together complex maintain...
Genome-wide association studies identified single-nucleotide polymorphism (SNP) rs55958994 as a significant variant associated with increased susceptibility to prostate cancer. However, the mechanisms by which this SNP mediates risk cancer are still unknown. In study, we show that is located in an enhancer active cells. Deletion of from tumor cells resulted decreased initiation, growth, and invasive migration, well loss stem-like Using combination capture chromosome conformation (Capture-C)...
Abstract Genome-wide association studies (GWAS) have identified >100 independent susceptibility loci for prostate cancer, including the hot spot at 8q24. However, how genetic variants this locus confer disease risk hasn’t been fully characterized. Using circularized chromosome conformation capture (4C) coupled with next-generation sequencing and an enhancer 8q24 as “bait”, we genome-wide partners interacting in cell lines LNCaP C4-2B. These 4C-identified regions are distributed open...
The increasing demand for compact and high-performance photonic devices drives the development of optical resonators with nanoscale sizes ultrahigh quality factors. Fabry-Pérot (FP) resonators, most widely employed can support factors in simple structure, which is particularly attractive applications lasers, filters, ultrasensitive sensors. However, construction FP both high has still faced challenges. Herein we demonstrate nanoresonators out single Au nanodisks (NDs) a film, WS2 flake...
180 Background: A considerable number of patients with stage II-III colon cancer experience disease recurrence following definitive treatment while others may receive unnecessary toxicity from adjuvant chemotherapy. Minimal residual (MRD) detection through ctDNA analysis can be evaluated without reliance on tissue which comes logistic advantages and the only option for limited tumor specimens. Methods: COSMOS-CRC-01 is an ongoing biomarker study that enrolled resectable 0-III colorectal...
Abstract Background: The detection of ctDNA in patients with early-stage breast cancer after completion adjuvant therapy is associated a high risk recurrence. Current clinical guidelines do not recommend routine screening for metastatic disease unless there are signs and symptoms who completed therapy. However, may serve as an early biomarker recurrence which allow effective identification asymptomatic distant metastases or molecular relapse only, could benefit from treatment intervention....
Developing efficient electrocatalysts is very important for water electrolysis technology to deal with the energy crisis. The oxygen evolution reaction (OER) in semireaction of electrolytic a crucial step. Herein, we report facial strategy fabricate bird nest-like Fe3O4/CoOx (BN-Fe3O4/CoOx) nanosphere heterojunctions amorphous/crystalline (a/c) structure through cation-exchange and subsequent calcination treatment reducing Ar/H2 atmosphere. Owing its unique electron state near heterogeneous...
Herein, we report a strategy to fabricate hollow ternary metal selenide (CoNiFe–Se) nanocubes derived from Prussian blue analogues (PBAs) by phytic acid etching and low-temperature gas-phase selenization.
Abstract Introduction: Distinguishing between tumor derived variants and those from clonal hematopoiesis (CH, or CHIP) can impact clinical decisions. It is essential to develop tools that accurately differentiate vs CH in tests with expanded gene panels. One method confirm involves sequencing both the buffy coat plasma samples. However, this approach cost-prohibitive has two key limitations: detection sensitivity of for low allele fractions, possibility originate tissues other than immune...
The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay genetic or epigenetic components, but the underlying mechanism incompletely understood. Here, we demonstrate that Suppressor Mek null (Smek) interact with methyl-CpG–binding domain 3 (Mbd3) and plays critical role in self-renewal neuronal differentiation NPCs. We found Smek promotes Mbd3 polyubiquitylation degradation, blocking recruitment repressive Mbd3/nucleosome remodeling deacetylase...
Significance Receptor-like tyrosine kinase (Ryk) is a Wnt receptor and important for many developmental processes, including cranial facial development, neurogenesis, axon guidance. However, little known about the role of intracellular domain, Ryk-ICD, in signal transduction. Its downstream targets are also unknown. We have previously shown that Ryk-ICD located cytoplasm neural stem cells whereas it moves into nucleus upon neuronal differentiation. In this study, we discovered Smek1/2...
Glioblastoma multiforme (GBM) heterogeneity causes a greater number of deaths than any other brain tumor, despite the availability alkylating chemotherapy. GBM stem-like cells (GSCs) contribute to complexity and chemoresistance, but it remains challenging identify target GSCs or factors that control their activity. Here, we identified specific GSC subset show activity these is positively regulated by stabilization methyl CpG binding domain 3 (MBD3) protein. MBD3 binds CK1A BTRCP E3 ubiquitin...
Both 3D chromatin architecture and long non-coding RNAs (lncRNAs) play essential roles in pluripotency maintenance. However, whether lncRNAs are involved organizing structure remains largely unexplored. We identified 39 bound by Klf4, among which we further revealed the 5430416N02Rik promoter is a interaction hub. Knockout of locus reduces proliferation rate embryonic stem cells (ESCs). Moreover, deleting both gene body causes more severe defect has profound impact on transcriptome than...
Nuclear architecture underlies the transcriptional programs within cell to establish identity. As previously demonstrated, long-range chromatin interactions of Oct4 distal enhancer (DE) are correlated with active transcription in naïve state embryonic stem cells. Here, we identify and characterize extreme DE through a novel CRISPR labeling technique developed chromosome conformation capture lethal giant larvae 2 (Llgl2) growth factor receptor-bound protein 7 (Grb7) as putative functional...
Circularized Chromosome Conformation Capture followed by deep sequencing (4C-Seq) is a powerful technique to identify genome-wide partners interacting with pre-specified genomic locus. Here, we present computational and statistical approach analyze 4C-Seq data generated from both enzyme digestion sonication fragmentation-based methods. We implemented command line software tool web interface called w4CSeq, which takes in the raw 4C (FASTQ files) as input, performs automated analysis presents...
With declining birth rates, and decreasing family sizes being witnessed around the world, helicopter parenting-characterized by high warmth, control, low empowerment-is becoming increasingly common among parents. Parenting styles exert long-term effects on individuals' cognition behavior, not only in early childhood, but also adulthood: therefore, within this context, study explored underlying influence mechanism of parenting style interpersonal conflict, through a survey 505 Chinese college...
Background Due to the lack of further studies on influence age factors plantar fasciitis, this study evaluates characteristic observation points magnetic resonance imaging in various cohorts patients with fasciitis help diagnosis. Methods A retrospective analysis 160 cases and normal subjects (who have disease unrelated fasciitis) who undergone an MRI examination our institution. The two groups were separately divided into young adult (36 44 years old), middle (45 59 older (60 79 old). Data...
Abstract Background: Assessing how clinical resistance to PARP inhibitors develops has been challenging, due the lack of coverage potential genes in sequencing panels and biopsies being subject spatial heterogeneity. We studied development PARPi and/or platinum resistant disease using both tissue a novel liquid biopsy assay, patients treated for BRCA1/2-mutated metastatic breast cancer (BRCA1/2m mBC). Approach: A cohort 35 mBC with germline or somatic BRCA1/2 mutations were identified as...
Cobalt-based spinel oxides are considered potential candidates for the oxygen evolution reaction (OER) due to their abundant valence changes and promising electrochemical activity, but low intrinsic activity hinders practical applications. Herein, we synthesize a series of CoCeMOx (M = Zn, Ni, Ru, Er, Mg, Mn, Sn) derived from CoCeM coordination-driven self-assembled aggregates (CDSAAs) using general ion exchange subsequent calcination method. Interestingly, exhibit different morphologies...
Abstract Genome structure or nuclear organization has fascinated researchers investigating genome function. Recently, much effort gone into defining relationships between specific structures and gene expression in pluripotent cells. We previously analyzed chromosomal interactions of the endogenous Oct4 distal enhancer Here, we derive ES iPS cells from a transgenic reporter mouse. Using sonication-based Circularized Chromosome Conformation Capture (4C) coupled with next generation sequencing,...
Abstract Background: ctDNA has shown promise as a prognostic biomarker in early-stage solid tumors. Current breast cancer clinical guidelines do not recommend routine screening for metastatic disease outside of features suggestive recurrence. The detection may be useful the management patients to identify who are at high risk Methods: Patients with stage II or III TNBC undergoing neoadjuvant docetaxel and carboplatin chemotherapy on trial (NCT02124902) followed by surgery were included this...