A5022072240- Skin and Cellular Biology Research
- Hair Growth and Disorders
- melanin and skin pigmentation
- Wound Healing and Treatments
- Cellular Mechanics and Interactions
- Genomics and Chromatin Dynamics
- Developmental Biology and Gene Regulation
- Amphibian and Reptile Biology
- Plant Gene Expression Analysis
- Magnetic and transport properties of perovskites and related materials
- Electrospun Nanofibers in Biomedical Applications
- Genomics and Phylogenetic Studies
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Biochemical Analysis and Sensing Techniques
- Pluripotent Stem Cells Research
- Physics of Superconductivity and Magnetism
- Animal Ecology and Behavior Studies
- Olfactory and Sensory Function Studies
- RNA Research and Splicing
- Electronic and Structural Properties of Oxides
- Genetic diversity and population structure
- Animal testing and alternatives
- Silk-based biomaterials and applications
- Animal Vocal Communication and Behavior
China Medical University
2015-2025
China Medical University Hospital
2014-2025
Zhejiang Hospital
2025
Duke-NUS Medical School
2025
Fujian Medical University
2025
First Affiliated Hospital of Fujian Medical University
2025
Dongguan People’s Hospital
2024
Southern Medical University
2024
Nanjing Agricultural University
2024
National Taiwan University
1991-2021
Lineage commitment and tumorigenesis, traits distinguishing stem cells, have not been well characterized compared in mesenchymal cells derived from human dental pulp (DP-MSCs) bone marrow (BM-MSCs). Here, we report DP-MSCs exhibit increased osteogenic potential, possess decreased adipogenic form dentin pulp-like complexes, are resistant to oncogenic transformation when BM-MSCs. Genome-wide RNA-seq differential expression analysis reveal differences adipocyte osteoblast differentiation...
Organoids made from dissociated progenitor cells undergo tissue-like organization. This in vitro self-organization process is not identical to embryonic organ formation, but it achieves a similar phenotype vivo. implies genetic codes do specify morphology directly; instead, complex tissue architectures may be achieved through several intermediate layers of cross talk between information and biophysical processes. Here we use newborn adult skin organoids for analyses. Dissociated mouse form...
Significance Avian skin appendages include feathers, scales, claws, and beaks. They are mainly composed of α-keratins, found in all vertebrates, β-keratins, only birds reptiles. Scientists have wondered how keratins interwoven to form different appendages. By studying keratin gene expression patterns chicken appendages, we α- β-keratin interactions crucial for appendage morphogenesis. Mutations either or β-keratins can disrupt cause structural defects. Thus, combinations contribute the...
Spatial variation of communities composition (metacommunities) results from multiple assembly mechanisms, including environmental filtering and dispersal; however, whether why the relative importance mechanisms in shaping bacterial metacommunity changes through time marine pelagic systems remains poorly studied. Here, we applied elements structure framework partitioning to examine temporal hydrographic conditions influences bacterioplankton dynamics southern East China Sea (ECS). The...
Abstract Tissue regeneration is a process that recapitulates and restores organ structure function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice ( Mus ), the limited to center of wound unlike those observed African spiny Acomys ) mice. mechanics been implicated as an integral part tissue morphogenesis. Here, we use WIHN model investigate mechanical molecular responses mice, report these models demonstrate opposing trends spatiotemporal...
The origin of feathers is an important question in Evo-Devo studies, with the eventual evolution vaned which are aerodynamic, allowing feathered dinosaurs and early birds to fly venture into new ecological niches. Studying how scales developmentally specified provides insight a organ may evolve. We identified feather-associated genes using genomic analyses. candidate were tested by expressing them chicken alligator scale forming regions. Ectopic expression these induced intermediate...
Animal skin pigment patterns are excellent models to study the mechanism of biological self-organization. Theoretical approaches developed mathematical patterning and molecular genetics have brought progress; however, responsible cellular is not fully understood. One long unsolved controversy whether information autonomously determined by melanocytes or nonautonomously from environment. Here, we transplanted purified demonstrated that could form periodic cell autonomously. Results...
We analyzed bacterial communities of six distinct gut sites (the food bolus and mucus layer the proximal small intestine, cecum distal large intestine), using wild folivorous flying squirrels. found significant spatial heterogeneity in composition, diversity, species abundance distributions (SADs) microbiota, corresponding to physicochemical conditions. High diversity was detected intestine cecum, followed by relatively low likely due disturbance resource partitioning. The SADs showed...
Abstract House mice ( Mus musculus ) are human commensals and have served as a primary model in biomedical, ecological evolutionary research. Although there is detailed knowledge of the biogeography house Europe, little known history China, despite fact that China encompasses an enormous portion their range. In present study, 535 caught from 29 localities were studied by sequencing mitochondrial D‐loop genotyping 10 nuclear microsatellite markers distributed on chromosomes. Phylogenetic...
Abstract Coat color variation due to melanin pigment synthesis in house mice Mus musculus Asia is described and found be consistent with Gloger's rule, which states that individuals of endothermic animals are darker humid habitats than those drier habitats. Three properties coat (hue, value chroma) were measured, a lightness variable was derived from principal components analysis using 428 skin specimens representing three subspecies 85 localities. Dorsal ranged yellow through brown black,...
Abstract Amniote skin appendages such as feathers, hairs and scales, provide thermoregulation, physical protection display different color patterns to attract a mate or frighten an adversary. A long-standing question is whether “reptile scale” “avian leg scales” are of the same origin. Understanding relation between avian scales reptilian will enhance our understanding appendage evolution. We compared molecular cellular profiles in chicken feather, alligator found that scutate similar...
Stem cells in organoids self-organize into tissue patterns with unknown mechanisms. Here, we use skin to analyze this process. Cell behavior videos show that the morphological transformation from multiple spheroidal units morphogenesis competence (CMU) planar is characterized by two abrupt cell motility–increasing events before calming down. The self-organizing processes are controlled a morphogenetic module composed of molecular sensors, modulators, and executers. Increasing dermal...
The integument plays a critical role in functional adaptation, with macro-regional specification forming structures like beaks, combs, feathers, and scales, while micro-regional modifies skin appendage shapes. However, the molecular mechanisms remain largely unknown. Craniofacial displays dramatic diversity, exemplified by Polish chicken (PC) homeotic transformation of comb-to-crest caused 195–base pair (bp) duplication HoxC10 intron. Micro-C analyses show that HoxC-containing topologically...
Introduction: The aim of this article was to explore the rehabilitation effects early precision exercise on patients with hemiplegia due acute ischemic stroke (AIS) and its effect in improving neurological function, motor ability, self-care daily life assess impact treatment levels patients’ inflammatory factors (such as TNF-α, hs-CRP, IL-6, IL-18), further understand potential mechanisms neural repair outcomes Material Method: A retrospective inclusion 230 AIS conducted, were grouped: group...
Abstract Introduction: C-X-C motif chemokine receptor 4 (CXCR4) is highly expressed by many kinds of tumors. Radiolabeled Pentixafor/Pentixather as typical targeting CXCR4 radioligands have been widely used in clinical practice, while there still remains barriers such inadequate tumor uptake and high retention blood or liver. Therefore, we designed a novel CXCR4-targeted agent, JH12. This research evaluated the specificity, biodistribution, pahrmacokinetics, dosimetry 68Ga/177Lu-JH12...
Abstract Introduction: Fibroblast activation protein (FAP) is an ideal target for tumor imaging and therapy. To enhance uptake prolong the retention of FAP-targeting agents, we developed JH04, a novel cyclic peptide composed ligand. The objective this study to evaluate specificity, biodistribution, pharmacokinetics, dosimetry 68Ga/177Lu-JH04 through preclinical preliminary clinical investigations, compare these findings with those 68Ga/177Lu-FAP-2286. Methods: FAP-positive cell line...
Abstract Tissue patterning is critical for the development and regeneration of organs. To advance use engineered reconstituted skin organs, we study cardinal features important tissue hair regeneration. We find they spontaneously form spheroid configurations, with polarized epidermal cells coupled dermal through a newly formed basement membrane. Functionally, becomes competent morphogenetic units (CMU) that promote patterns. The emergence new cell types molecular interactions during CMU...