A5079024647- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Catalytic Cross-Coupling Reactions
- Neuroscience and Neuropharmacology Research
- Sulfur-Based Synthesis Techniques
- Microwave-Assisted Synthesis and Applications
- Intestinal and Peritoneal Adhesions
- Computational Drug Discovery Methods
- Carbon Nanotubes in Composites
- Radiopharmaceutical Chemistry and Applications
- Mesoporous Materials and Catalysis
- Fullerene Chemistry and Applications
- Tuberous Sclerosis Complex Research
- Synthesis and Properties of Aromatic Compounds
- Asymmetric Synthesis and Catalysis
- Plant Gene Expression Analysis
- Eosinophilic Disorders and Syndromes
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Cyclopropane Reaction Mechanisms
- Biochemical Analysis and Sensing Techniques
- Alzheimer's disease research and treatments
Shandong First Medical University
2020
Fudan University
1997-2019
GlaxoSmithKline (China)
2011-2018
Zhongshan Hospital
2008
Zhejiang University
2007
A novel and efficient protocol for the controllable synthesis of various di-, tri- tetra-substituted imidazoles <italic>via</italic> cascade palladium catalyzed C–C coupling followed by intramolecular C–N bond formation was developed.
A novel and regioselective Ni(I) catalyzed C-C C-N cascade coupling reactions has been developed. The furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines. regioselectivity of C(sp3)-cyano group over C(sp2)-cyano was revealed supported by mechanism studies as well the preliminary density functional theory (DFT) calculations.
Abstract Introduction: Fibroblast activation protein (FAP) is an ideal target for tumor imaging and therapy. To enhance uptake prolong the retention of FAP-targeting agents, we developed JH04, a novel cyclic peptide composed ligand. The objective this study to evaluate specificity, biodistribution, pharmacokinetics, dosimetry 68Ga/177Lu-JH04 through preclinical preliminary clinical investigations, compare these findings with those 68Ga/177Lu-FAP-2286. Methods: FAP-positive cell line...
Abstract A convenient Ni(II)‐catalyzed C−C and C−N cascade coupling reaction was developed to directly access various 2,4‐disubstituted imidazoles. The scope covers a variety of aryl aliphatic substitutions, which demonstrate moderate‐to‐excellent yields. tolerance halogen N ‐containing heterocyclic groups demonstrates the versatility this method for further synthetic explorations. magnified image
A convenient microwave-assisted protocol for the synthesis of hydroxyl-containing isoquinolines from a metal-free radical cyclization reaction vinyl isonitriles with alcohols was developed moderate-to-excellent yields.
A metal-free radical cyclization reaction of vinyl isocyanides with alkanes is developed, allowing convenient access to a diverse range potentially valuable 1-alkylisoquinolines. The methodology simple and efficient, demonstrating excellent functional group tolerance broad substrate scope. mechanism involving process supported by kinetic isotope effect inhibition studies.
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