This review summarizes the complex relationship between medications used to treat type 2 diabetes and bone health. T2DM patients face an increased fracture risk despite higher mineral density; thus, we analyzed impact of key drug classes, including Metformin, Sulphonylureas, SGLT-2 inhibitors, DPP-4 GLP-1 agonists, Thiazolidinediones. promising preclinical results, lacks a clear consensus on its role in reducing risk. Sulphonylureas present conflicting data, with potential neutral effects...

Wound healing represents an interactive process which requires highly organized activity of various cells, synthesizing cytokines, growth factors, and collagen. Collagen types I III, serving as structural regulatory molecules, play pivotal roles during wound healing. The aim this study was to compare the propolis silver sulfadiazine therapeutic efficacy throughout quantitative qualitative assessment collagen III accumulation in matrix burnt tissues. Burn wounds were inflicted on pigs, chosen...

Changes in extracellular matrix glycosaminoglycans during the wound repair allowed us to apply burn model which therapeutic efficacy of propolis and silver sulfadiazine was compared. Burns were inflicted on four pigs. Glycosaminoglycans isolated from healthy burned skin quantified using a hexuronic acid assay, electrophoretic fractionation, densitometric analyses. Using reverse-phase HPLC profile sulfated disaccharides released by chondroitinase ABC chondroitin/dermatan sulfates estimated....

Secular trend in childhood obesity is a well-known phenomenon, and it important to monitor cross-sectional studies. The study aim was estimate prevalence of overweight Polish 7- 9-year-old children compare the results with French based on same protocol.The conducted 2001 according protocol European Childhood Obesity Group. Height weight were measured, BMI calculated define nutritional status randomly selected group 2916 (1445 girls 1471 boys) primary school children. estimated International...

This review summarises the complex relationship between medications used to treat type 2 diabetes, and bone health. T2DM patients face an increased fracture risk despite higher mineral density, thus we analysed impact of key drug classes, including Metformin, Sulphonylureas, SGLT-2 inhibitors, DPP-4 GLP-1 agonists, Thiazolidinediones.
 promising preclinical results, lacks a clear consensus on its role in reducing risk. Sulphonylureas present conflicting data, with potential neutral...

<i>Background:</i> The mechanisms which cause age-dependent remodeling of connective tissue are still not fully understood. Matrix metalloproteinases (MMPs) and inhibitors (TIMPs) constitute an important proteolytic pathway affecting physiological matrix remodeling. <i>Objective:</i> way in changes the extracellular metabolism during ageing process influence level circulating MMP-3 MMP-10, as well their TIMP-1 TIMP-2, a healthy population was investigated this study....

Wstęp Niewydolność serca z zachowaną frakcją wyrzutową (<i>heart failure with preserved ejection fraction</i> – HFpEF) charakteryzuje się dysfunkcją rozkurczową lewej komory (<i>left ventricle</i> LV). Zaburzenia funkcji rozkurczowej powodują zator płucny i prowadzą do zakapilarnego nadciśnienia płucnego (<i>pulmonary hypertension</i> PH), które jest istotnym czynnikiem pogorszenia stanu klinicznego zwiększonej śmiertelności. Materiał metody Przeprowadzono...

To examine the trend in prevalence of overweight and obesity schoolchildren from south-eastern Poland over a 10-year period.A cross-sectional study was conducted randomly selected primary schools. In total, 4,248 children (2,182 boys 2,066 girls), mean age 10.5±2.4 years, were examined 1998, 2,412 (1,184 1,228 10.5±2.3 years 2008. each school entire population studied.In 2008, girls 13.3% 7.7%, compared to 12.0% 10.1% 1998. The decrease statistically significant. boys, 2008 14.2% 6.4%, 10.5%...

Introduction: The study aim was to evaluate risk factors of obesity in Polish children aged 7 9 years.Material and methods: A representative group 2571 (1268 girls 1303 boys) randomly selected according the European Childhood Obesity Group protocol.Weight height were measured body mass index (BMI) calculated.A questionnaire completed by children's parents with respect behavioural family-related obesity.International Task Force criteria used for classification obesity.Results: found 3.7% 3.6%...

Background: The authors studied the role of increased oxidative stress in development protein damage and extracellular matrix (ECM) components ageing. age- gender-associated disturbances connective tissue metabolism were evaluated by plasma chondroitin sulphated glycosaminoglycans (CS-GAG) non-sulphated GAG-hyaluronan (HA) measurements. Plasma concentration advanced oxidation products (AOPP) was analysed order to assess evaluate possible deleterious phenomenon on proteoglycans’ during...

Abstract Objective: To assess the frequency of obesity, overweight and underweight (thinness) in Polish 7–9‐year‐old children using a population specific definition as compared to French, US IOTF references based on body mass index (BMI). Design: Height weight were measured BMI was calculated randomly selected representative sample (N = 2916; 1445 girls; 1471 boys) define their nutritional status. Overweight (including obesity) estimated according four three definitions national references;...

Abstract The aim of this study was to evaluate the possibility incorrect assessment mortality risk factors in a group patients affected by acute coronary syndrome, due lack hazard proportionality Cox regression model. One hundred and fifty consecutive with syndrome (ACS) no age limit were enrolled. Univariable multivariable proportional analyses performed. assumptions verified using Schoenfeld residuals, χ 2 test rank correlation coefficient t between residuals time. In total 150 patients,...

Kawasaki disease (KD) remains a diagnostic challenge due to its nonspecific clinical symptoms. Delayed treatment initiation increases the risk of coronary complications.To evaluate artery involvement and perform prospective analysis course in children hospitalised KD.KD was diagnosed 38 children, including 25 boys 13 girls, aged 1.5-118 months (median 37.5 months). We assessed cardiac complications relation presence complete or incomplete form disease, age, gender laboratory test results, as...

Introduction and purpose: In recent years there has been an increase in scientific research regarding the body's exposure to low temperatures. The potential health benefits have captured attention of both researchers general public. This article review provides analysis existing literature concerning impact cold body on athletic achievements. Material methods: A available "PubMed" database books was conducted. search performed by using following keywords: "cold exposure", "cryotherapy",...

Introduction: Atrial functional mitral regurgitation (afMR) is common in patients with atrial fibrillation (AF). The presence of tricuspid (fTR), which arises as a secondary effect afMR, has the potential to impact effectiveness procedures aimed at restoring normal heart rhythm. In this study, we sought evaluate efficacy electrical cardioversion (CVE) AF regarding and degree fTR afMR. Material methods: Retrospective analysis included 521 persistent on optimal medical therapy undergoing CVE....

Abstract Background: In this study, the effect of gender and physio-logical ageing on circulating concentrations plasma sulfated glycosaminoglycans (sGAG) as well molecules involved in pro- (tumor necrosis factor-α; TNF-α) anti-inflammatory responses (soluble tumor factor receptor-1, sTNF-RI) were assessed. The relationships between sGAG age-dependent extracellular matrix (ECM) remodeling during physiological also investigated. Methods: Circulating TNF-α sTNF-RI measured 91 healthy...

Study Objectives . The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants Lipid levels 16 diabetic biochemical (T1DM-H) aged 16.3 ± 1.2 years were compared 38 normal androgen (T1DM-N) 15.8 years. 15 healthy served as controls (CG). In all patients, anthropometric measurements done, androgens SHBG assessed. Results T1DM-H, total cholesterol (TC) low density (LDL-ch)...

The objective of the study is to assess external and internal exposures aromatic hydrocarbons in tar oil naphthalene distillation processes at a coke plant. 69 workers engaged as operators 25 non-exposed subjects were examined. Personal analyses benzene, toluene, xylene isomers, ethylbenzene, naphthalene, indan, indene acenaphthene breathing zone air allowed us determine time weighted average exposure levels listed above. was investigated by measurement urinary excretion naphthols,...