A5059013782- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- CRISPR and Genetic Engineering
The University of Texas at Austin
2020-2024
Io Therapeutics (United States)
2020
End-stage organ failure remains a leading cause of morbidity and mortality across the globe. The only curative treatment option currently available for patients diagnosed with end-stage is transplantation. However, due to critical shortage organs, fraction these are able receive viable Those fortunate enough transplant must then be subjected lifelong regimen immunosuppressant drugs. concept whole engineering offers promising alternative transplantation that overcomes limitations. Organ...
The human heart's limited regenerative capacity is a significant barrier to addressing cardiovascular disease (CVD). This particularly true for cardiac fibrosis, form of CVD wherein the wound healing process has gone awry. In excessive scar tissue formation due dysregulated remodeling extracellular matrix (ECM) results in increased stiffness that reduces output and can lead heart failure. ECM deposition driven by activated fibroblasts, where cell substrate known play role fibroblast...
Abstract Human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) hold great potential to resolve cardiovascular disease but are stymied by their functional immaturity. The complex electric potentials measured during cardiogenesis point the of exogenous electrical stimulation in improving cardiac differentiation and functionality. Herein, we create, validate, implement a low-cost device stimulate hiPSCs differentiation. Notably, our open-source enables generation regimes...
The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) is greatly limited by their functional immaturity. Strong relationships exist between cardiomyocyte (CM) structure and function, leading many in the field to seek ways mature hiPSC-CMs culturing on biomimetic substrates, specifically those that promote alignment. However, these vitro models have so far failed replicate alignment occurs during cardiac differentiation. We show engineered alignment,...
Abstract The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) is greatly limited by their functional immaturity. Strong relationships exist between CM structure and function, leading many in the field to seek ways mature hiPSC-CMs culturing on biomimetic substrates, specifically those that promote alignment. However, these vitro models have so far failed replicate alignment occurs during cardiac differentiation. We show engineered alignment,...