A5105864117- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
University of South Florida
2024-2025
DNA double-strand breaks (DSBs) are harmful lesions and major sources of genomic instability. Studies have suggested that DSBs induce local transcriptional silencing consequently promotes stability. Several factors been proposed to actively participate in this process, including Ataxia-telangiectasia mutated (ATM) Polycomb repressive complex 1 (PRC1). Here, we found disrupting PRC1 clustering disrupts DSB-induced gene silencing. Interactome analysis PHC2, a subunit the clustering, several...
<title>Abstract</title> DNA Double-strand breaks (DSBs) are harmful lesions and major sources of genomic instability. Studies have suggested that DSBs induce local transcriptional silencing consequently promotes stability. Several factors been proposed to actively participate in this process, including ATM Polycomb repressive complex 1 (PRC1). Here we found disrupting PRC1 clustering disrupts DSB-induced gene silencing. Interactome analysis PHC2, a subunit the formation body, several...