A5104228610- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- RNA modifications and cancer
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Advanced Breast Cancer Therapies
- Microtubule and mitosis dynamics
- Amino Acid Enzymes and Metabolism
- RNA Interference and Gene Delivery
- Biotin and Related Studies
- Mechanisms of cancer metastasis
New York University
2024-2025
NYU Langone Health
2025
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2024
Although mismatch repair (MMR) is essential for correcting DNA replication errors, it can also recognize other lesions, such as oxidized bases. In G0 and G1, MMR kept in check through unknown mechanisms error-prone during these cell cycle phases. We show that mammalian cells, D-type cyclins are recruited to sites of oxidative damage a PCNA- p21-dependent manner. inhibit the proteasomal degradation p21, which competes with proteins binding PCNA, thereby inhibiting MMR. The ability limit CDK4-...
In healthy cells, cyclin D1 is expressed during the G1 phase of cell cycle, where it activates CDK4 and CDK6. Its dysregulation a well-established oncogenic driver in numerous human cancers. The cancer-related function has been primarily studied by focusing on phosphorylation retinoblastoma (RB) gene product. Here, using an integrative approach combining bioinformatic analyses biochemical experiments, we show that GTSE1 (G-Two S phases protein 1), positively regulating cycle progression,...
In healthy cells, cyclin D1 is expressed during the G1 phase of cell cycle, where it activates CDK4 and CDK6. Its dysregulation a well-established oncogenic driver in numerous human cancers. The cancer-related function has been primarily studied by focusing on phosphorylation retinoblastoma (RB) gene product. Here, using an integrative approach combining bioinformatic analyses biochemical experiments, we show that GTSE1 (G-Two S phases protein 1), positively regulating cycle progression,...
DNA double-strand breaks (DSBs) are harmful lesions and major sources of genomic instability. Studies have suggested that DSBs induce local transcriptional silencing consequently promotes stability. Several factors been proposed to actively participate in this process, including Ataxia-telangiectasia mutated (ATM) Polycomb repressive complex 1 (PRC1). Here, we found disrupting PRC1 clustering disrupts DSB-induced gene silencing. Interactome analysis PHC2, a subunit the clustering, several...
ABSTRACT The large majority of oxidative DNA lesions occurring in the G1 phase cell cycle are repaired by base excision repair (BER) rather than mismatch (MMR) to avoid long resections that can lead genomic instability and death. However, molecular mechanisms dictating pathway choice between MMR BER have remained unknown. Here, we show that, during G1, D-type cyclins recruited sites damage a PCNA- p21-dependent manner. shield p21 from its two ubiquitin ligases CRL1 SKP2 CRL4 CDT2...
Cyclin D1 is the activating subunit of cell cycle kinases CDK4 and CDK6, its dysregulation a well-known oncogenic driver in many human cancers. The biological function cyclin has been primarily studied by focusing on phosphorylation retinoblastoma (RB) gene product. Here, using an integrative approach combining bioinformatic analyses biochemical experiments, we show that GTSE1 (G2 S phases expressed protein 1), positively regulating progression, previously unknown substrate D1-CDK4/6....
<title>Abstract</title> DNA Double-strand breaks (DSBs) are harmful lesions and major sources of genomic instability. Studies have suggested that DSBs induce local transcriptional silencing consequently promotes stability. Several factors been proposed to actively participate in this process, including ATM Polycomb repressive complex 1 (PRC1). Here we found disrupting PRC1 clustering disrupts DSB-induced gene silencing. Interactome analysis PHC2, a subunit the formation body, several...
Cyclin D1 is the activating subunit of cell cycle kinases CDK4 and CDK6, its dysregulation a well-known oncogenic driver in many human cancers. The biological function cyclin has been primarily studied by focusing on phosphorylation retinoblastoma (RB) gene product. Here, using an integrative approach combining bioinformatic analyses biochemical experiments, we show that GTSE1 (G2 S phases expressed protein 1), positively regulating progression, previously unknown substrate D1-CDK4/6....
Cyclin D1 is the activating subunit of cell cycle kinases CDK4 and CDK6, its dysregulation a well-known oncogenic driver in many human cancers. The biological function cyclin has been primarily studied by focusing on phosphorylation retinoblastoma (RB) gene product. Here, using an integrative approach combining bioinformatic analyses biochemical experiments, we show that GTSE1 (G2 S phases expressed protein 1), positively regulating progression, previously unknown substrate D1-CDK4/6....