A5003783081- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Tumors and Oncological Cases
- Advanced Radiotherapy Techniques
- Neuroendocrine Tumor Research Advances
- Renal Transplantation Outcomes and Treatments
- Renal and related cancers
- Soft tissue tumor case studies
Banner - University Medical Center Tucson
2022-2024
University of Arizona
2022-2024
University of Arizona Cancer Center
2022
Phoenix Children's Hospital
2018-2021
Cell-free DNA (cfDNA) in urine is a promising analyte for noninvasive diagnostics. However, cfDNA highly fragmented. Whether characteristics of these fragments reflect underlying genomic architecture unknown. Here, we characterized fragmentation patterns using whole-genome sequencing. Size distribution showed multiple strong peaks between 40 and 120 base pairs (bp) with modal size 81- sharp 10-bp periodicity, suggesting transient protection from complete degradation. These properties were...
Abstract Cell-free DNA (cfDNA) in urine is a promising analyte for noninvasive diagnostics. However, cfDNA highly fragmented and whether characteristics of these fragments reflect underlying genomic architecture unknown. Here, we perform comprehensive characterization fragmentation patterns cfDNA. We show modal size genome-wide distribution are consistent with transient protection from degradation by stable intermediates nucleosome disassembly. Genome-wide occupancy fragment sizes...
A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift immaturity, basophilia or eosinophilia. While the peripheral blood bone marrow findings initially suggested essential thrombocythemia, BCR-ABL1 translocation detected chronic myeloid leukemia, phase, diagnosed. Apheresis for platelet depletion performed as a bridge given delayed effects of medical therapy.
A full-term infant with an unremarkable prenatal course presented at birth a large midline facial mass and smaller masses in the head neck. In addition, multiple diffuse flesh-colored nodules spread along all upper lower limbs. An extensive evaluation to cover broad differential diagnosis of infectious, lymphatic/vascular, oncologic etiology was undertaken. The initial suspicion confirmed by biopsy skin lesion as congenital alveolar rhabdomyosarcoma (RMS). RMS is most common soft tissue...
PurposeThe purpose of this investigation was to evaluate the efficacy and safety stereotactic body radiotherapy (SBRT) for pulmonary metastases from pediatric sarcomas.MethodsThis study a single institutional retrospective chart review including patients younger than 21 years age at diagnosis who had received SBRT metastasis metastatic sarcoma. Our current electronic record system queried all eligible patients. Primary endpoint tumor response as defined by RECIST 1.1 criteria. Secondarily,...
Pancreatoblastoma, a rare pancreatic tumor, exhibits diverse differentiation pathways, including acinar, ductal, and neuroendocrine lineages, often with distinct squamoid nests [3]. We present notable case of pancreatoblastoma coexisting large cell carcinoma in 10-year-old boy, presenting abdominal discomfort, weight loss, lesions the pancreas, spleen, liver visible on imaging. A biopsy revealed poorly differentiated features, while splenic showed acinar differentiation, raising possible...
Allogeneic hematopoietic cell transplantation (allo-HCT) remains a curative option for patients with high-risk myeloid malignancies.We present our 10-year experience (October 2012 to October 2021) of consecutive allo-HCT in malignancies treated on the pediatric HCT service and conditioned myeloablative targeted dose-busulfan (BU), fludarabine (FLU), melphalan (MEL). Twenty-three children, adolescents, young adult (CAYA) (median age 15.4 years) acute leukemia (AML, n = 17), myelodysplastic...
Abstract Cell-free DNA (cfDNA) in plasma has been shown to be a promising analyte for noninvasive diagnostics. The collection of blood requires venipuncture, and volume obtainable at single point is limited. In contrast, cfDNA urine can collected noninvasively, with minimal assistance larger volumes. However, so far there limited success diagnostic development using as highly fragmented, whether the characteristics these fragments reflect underlying genomic architecture unknown. Here, we...
Abstract Background: Allogeneic hematopoietic cell transplantation (allo-HCT) remains a curative option for patients with high-risk myeloid malignancies. Objectives : We reviewed our ten-year experience (October 2012 thru October 2021) of allo-HCT in malignancies treated on the pediatric HCT service and conditioned myeloablative targeted dose-busulfan (BU), fludarabine (FLU) melphalan (MEL). Study Design: Twenty-three children, adolescents, young adult (CAYA) (median age 15.4 years, range...
Background: Allogeneic hematopoietic cell transplantation (allo-HCT) remains a curative option for patients with high-risk myeloid malignancies. Procedure: We present our ten-year experience (October 2012-October 2021) of consecutive allo-HCT in malignancies treated on the pediatric HCT service and conditioned myeloablative targeted dose-busulfan (BU), fludarabine (FLU) melphalan (MEL). Twenty-three children, adolescents, young adult (CAYA) (median age 15.4yr) acute leukemia (AML, n=17),...