A5027159451- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Infective Endocarditis Diagnosis and Management
- Drug-Induced Adverse Reactions
- Orthopedic Infections and Treatments
- Neonatal and Maternal Infections
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Vitamin D Research Studies
- Cytomegalovirus and herpesvirus research
- Vitamin C and Antioxidants Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Ethics in Clinical Research
- Dermatological diseases and infestations
- Mycobacterium research and diagnosis
- Pharmacovigilance and Adverse Drug Reactions
- Fungal Infections and Studies
- Microfluidic and Capillary Electrophoresis Applications
- Antibiotic Use and Resistance
- Viral Infections and Outbreaks Research
- Impact of AI and Big Data on Business and Society
- Bacterial Identification and Susceptibility Testing
Rainbow Babies & Children's Hospital
2018-2025
Case Western Reserve University
2020-2024
University School
2023-2024
Cleveland Research (United States)
2021
University Hospitals of Cleveland
2021
Center for Clinical Research (United States)
2020
Goa Medical College
2015
Children's Healthcare of Atlanta
2015
Emory University
2015
Streptococcus pneumoniae (SP) serotype distribution among nasopharyngeal (NP) carriage isolates changed significantly after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7). We evaluated impact on NP and invasive disease SP 13-valent PCV (PCV13) in March 2010.NP swabs were collected from children 6-59 months age an emergency department July 2010 to June 2013. After broth enrichment, samples cultured for serotyped. Clinical immunization records reviewed. Findings during 6...
We investigated the association of vitamin K and D with coronavirus disease 2019 (COVID-19) outcomes.Levels inactive K-dependent dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP; marker status) 25-hydroxyvitamin (25(OH)D; were measured in plasma samples from participants confirmed acute COVID-19 age- sex-matched to healthy controls. Unadjusted odds ratios adjusted (AORs) 95% CIs computed using cumulative logistic regression.One hundred fifty subjects included, 100 COVID-19+ 50...
Background: Pneumonia has a major impact on childhood health and care costs. This study was designed to obtain contemporary information the clinical characteristics etiology of community-acquired pneumonia (CAP) in children from both inpatient outpatient settings USA. Methods: We conducted prospective, multicenter, observational CAP among previously healthy 2 months 18 years age 6 children’s hospitals Ohio 2015 2018. For pathogen detection, nasopharyngeal swabs were collected all subjects....
Background Few reports have been published on the clinical presentation of pediatric patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aim to shed more light disease 2019 (COVID-19), and also potential risk factors for case presentation. Methods used a large global health research network gather data extracted from electronic medical records aged < 18 years confirmed SARS-CoV-2 January 1, 2020 May 7, 2020. Clinical symptoms at presentation,...
Abstract Background Cytomegalovirus (CMV) is the most common viral cause of congenital defects in U.S. Early identification CMV (cCMV) infection allows for optimal antiviral treatment which reduces progression sensorineural hearing loss and improves neurodevelopmental outcomes. There varying guidance from expert consensus groups ranging universal screening to selective based on clinical features. With conflicting data, many hospitals have no standardized protocol cCMV screening. This study...
Objective: Mycoplasma pneumoniae (Mp) is the most detected bacterial pathogen in children with community-acquired pneumonia (CAP). Our primary objective was to compare clinical presentation, management, and outcomes of without Mp CAP across 6 children’s hospitals. Methods: Eligible were 2 months old or above diagnosed a prospective multicenter cohort study between October 1, 2015 June 31, 2018. Children excluded if they had complex chronic conditions. tested for via polymerase chain reaction...
Abstract Background Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality in children. Assessing disease severity etiology remains challenging the clinical setting. The objective this study was to identify mucosal biomarkers that could potentially assist with patient classification. Methods We analyzed concentrations cytokines nasopharyngeal samples obtained from convenience sample 182 children CAP 26 matched healthy controls. Pathogens were identified by cultures...
The use of 16S rRNA sequencing in culture-negative infections has improved identification bacterial pathogens select scenarios, but its clinical impact requires further elucidation, especially the pediatric population. This retrospective study aims to determine utility on management our institution. Significant was identified 30 (40.5%) 74 samples (p < 0.0001). Of all specimens, pulmonary yielded most (n = 9, 30%), followed equally by joint fluid 6, 20%) and bone 20%), with no difference...
Background: Less than 5% of children who report penicillin allergy have clinically pertinent type 1 immunoglobulin E mediated hypersensitivity reaction by using direct oral amoxicillin challenge. Several pathways been developed to delabel challenge, mostly in the outpatient settings, but there is relative scarcity on published outcomes these pathways, especially inpatient pediatric settings. Objective: This study aimed evaluate performance an institutionally derived screening tool. Methods:...
Human immunodeficiency virus (HIV) infection is now preventable with pre-exposure prophylaxis (PrEP) drugs, however, barriers to PrEP implementation include primary-care physician (PCP) knowledge-gap and lack of comfort prescribing managing PrEP. We hypothesized that integrating HIV-PrEP education during medical-residency would help address these problems developed a 40-minute case-based lecture focused on the 2021 United States Preventative Services Taskforce (USPSTF) oral guidelines...
Abstract Background Targeted antimicrobial regimens rely on prompt isolation and identification of the pathogen. When conventional gold standard culture-based methods fail to identify a pathogen, broad range PCR next-generation 16S rRNA sequencing has emerged as clinically useful increasingly frequent diagnostic tool. However, its impact in clinical decision making effect outcomes, particularly with negative results, remains poorly elucidated. This study aims evaluate adult infections....
Background: The development of broad-range polymerase chain reaction (BR-PCR) and next-generation sequencing techniques has significant implications for antimicrobial stewardship by increasing clinicians’ ability to provide a tailored regimen. We sought explore the clinical utility BR-PCR testing its impact on treatment among an adult cohort in large hospital system. Methods: retrospectively evaluated samples that underwent between 2017 2021 summarized their characteristics therapy....
While 10% of the population may report a penicillin (PCN) allergy, it has been shown that 90% these patients are not allergic and still be able to take PCN safely. Inaccurate reporting allergy lead prescription other non-B-lactam or broader spectrum antibiotics. Inpatients with reported antibiotic status have inappropriate prescribing, increase microbiologic resistance, suboptimal patient outcomes. Our goal was evaluate prescribing patterns for children CAP in setting allergy. The Children’s...
Abstract Background Worldwide, pneumonia is the leading cause of death in children <5 years age and second most common reason for hospitalization United States Europe. This study was designed to describe clinical characteristics etiology community-acquired (CAP) children. Methods We conducted a prospective, multicenter, observational CAP among previously healthy aged 2 months through 18 six children’s hospitals Ohio. Blood, pleural fluid, nasopharyngeal swabs were collected pathogen...
Abstract Background Only 1% of patients with penicillin allergy are truly allergic but it remains the most common drug reported. Studies show that direct oral challenge is a safe method to delabel low-risk using institutional screening stratification tools. There no verified universal tool perform this function, underscoring need address clinical gap. This study aims assess efficacy our questionnaire at correctly stratifying risk status and determine whether graded amoxicillin can be safely...
Abstract Background Community acquired pneumonia (CAP) is a leading cause of mortality in children &lt; 5 years, but our understanding disease pathogenesis remains limited. The objective this study was to define the local host immune response respiratory tract by measuring nasal mucosal cytokine (NMC) concentrations (conc.). We hypothesized that NMC represent potential biomarker help assessing severity and pathogen classification. Methods leveraged nasopharyngeal (NP) samples clinical...
Abstract Background This study describes the changing pattern of non-tuberculous, or atypical, mycobacteria (NTM) lymphadenitis over past five years in Northeast Ohio and analyzes factors that may be associated with this change. Particular attention will paid to any demographic geographic associations can linked pattern, assess for epidemiology. Methods A retrospective chart review was completed including patients presenting our tertiary medical center years. Patients clinical presentation...
Automated Teller Machine (ATM) is mostly used by the bank customers as it allows withdrawing cash quickly. For this purpose, sufficient should be available in ATM order to meet customer's requirement. Now-a-days, many people are searching location of ATMs through Google Maps but unfortunately peoples wasting their time search working ATM. We have proposed a system which consist mobile application and web module will help users find nearest check availability that using application. The...