A5083541221- Vitamin D Research Studies
- Bacterial Identification and Susceptibility Testing
- Cellular Mechanics and Interactions
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Blood properties and coagulation
- Antibiotic Resistance in Bacteria
- 3D Printing in Biomedical Research
- Ethics and Legal Issues in Pediatric Healthcare
- Microfluidic and Bio-sensing Technologies
- Hippo pathway signaling and YAP/TAZ
National Cheng Kung University
2015-2025
In vivo, epithelial cells maintain structural integrity under dynamic mechanical perturbations. To study this, we treated various cell lines with long-term cyclic stretch (CS). Surprisingly, transitioned from cuboidal to columnar shape (columnarization) in MDCK cells, while others only elongated. This change correlated actin accumulation at the top and stress fiber realignment bottom. Blocking stimulation via FAK inhibition or reducing vinculin partially prevented columnarization; however,...
Gram-negative bacteria (GNBs) are common pathogens causing severe sepsis. Rapid evaluation of drug susceptibility would guide effective antibiotic treatment and promote life-saving. A total 78 clinical isolates 13 species collected between April 2013 November from two medical centers in Tainan were tested. Bacterial morphology changes different concentrations antibiotics observed under the electric field a quadruple electrode array using light microscopy. The minimal inhibitory (MICs) four...
To investigate the effects of dietary methionine restriction (MetR) and endurance exercise on bone quality under a condition estrogen deficiency, female Sprague-Dawley rats (36-wk-old) were assigned to sham surgery group or one five ovariectomized groups subjected interventions no treatment (Ovx), (Exe), (MetR), plus (MetR + Exe), (Est). Rats in treadmill running regimen. MetR control diets contained 0.172 0.86% methionine, respectively. After 12-wk intervention, all animals killed, serum...