A5083086858- Cannabis and Cannabinoid Research
- Immune Cell Function and Interaction
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Connective tissue disorders research
- Photoreceptor and optogenetics research
- Laser Applications in Dentistry and Medicine
- Herbal Medicine Research Studies
- Protease and Inhibitor Mechanisms
- Urinary Bladder and Prostate Research
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Insect Utilization and Effects
- COVID-19 epidemiological studies
- Tea Polyphenols and Effects
- Diverse Scientific Research Studies
- Urinary Tract Infections Management
- Transgenic Plants and Applications
- Dermatological and Skeletal Disorders
- Vaccine Coverage and Hesitancy
- Invertebrate Immune Response Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Pediatric Urology and Nephrology Studies
- Cardiovascular Function and Risk Factors
Clemson University
2017-2023
Mississippi State University
2015-2020
Massachusetts General Hospital
2010-2012
The University of Tokyo
2010-2012
Abstract Background and Objectives Traumatic brain injury (TBI) affects millions worldwide is without effective treatment. One area that attracting growing interest the use of transcranial low‐level laser therapy (LLLT) to treat TBI. The fact near‐infrared light can penetrate into would allow non‐invasive treatment be carried out with a low likelihood treatment‐related adverse events. LLLT may TBI by increasing respiration in mitochondria, causing activation transcription factors, reducing...
Aim Abdominal aortic aneurysms (AAA) is a life-threatening weakening and expansion of the abdominal aorta due to inflammatory cell infiltration gradual degeneration extracellular matrix (ECM). There are no pharmacological therapies treat AAA. We tested hypothesis that nanoparticle (NP) therapy targets degraded elastin delivers anti-inflammatory, anti-oxidative, ECM stabilizing agent, pentagalloyl glucose (PGG) will reverse advance stage aneurysm in an elastase-induced mouse model Method...
Abstract Pulmonary hypertension worsens outcome in left heart disease. Stiffening of the pulmonary artery may drive this pathology by increasing right ventricular dysfunction and lung vascular remodeling. Here we show increased stiffness arteries from patients with disease that correlates impaired hemodynamics. Extracellular matrix remodeling arterial wall, manifested dysregulated genes implicated elastin degradation, precedes onset hypertension. The resulting degradation elastic fibers is...
Low level laser (or light) therapy (LLLT) has been clinically applied for many indications in medicine that require the following processes: protection from cell and tissue death, stimulation of healing repair injuries, reduction pain, swelling inflammation. One area is attracting growing interest use transcranial LLLT to treat stroke traumatic brain injury (TBI). The fact near-infrared light can penetrate into would allow non-invasive treatment be carried out with a low likelihood...
Abstract Abdominal aortic aneurysm (AAA) disease causes dilation of the aorta, leading to rupture and death if not treated early. It is 14th cause in U.S. 10th men over age 55, affecting thousands patients. Despite prevalence AAA, no safe efficient pharmacotherapies exist for The deterioration elastic lamina aneurysmal wall a consistent feature AAAs, making it an ideal target delivering drugs AAA site. In this research, we conjugated nanoparticles with elastin antibody that only targets...
A polysaccharide was purified from a hot water extract of green tea leaves by measuring the immunostimulatory activity in silkworm larvae. Nuclear magnetic resonance and chemical analysis acid hydrolysates revealed that substance possessed backbone containing polygalacturonic acids with methyl ester residues. Treatment β-glucanase attenuated muscle contraction sample, suggesting β-glucan structure, probably as branched form, required for its activity. The fraction stimulated production...
Abstract Cannabis sativa-derived cannabinoid compounds are being investigated as potential immunosuppressive agents and important drug candidates for immune related diseases. Our previous data demonstrated that under conditions of suboptimal T cell activation, cannabidiol (CBD) could increase interleukin-2 (IL-2) production. Initially this result was surprising given cannabinoids immunosuppressive, but IL-2 can also contribute to regulatory (Treg) induction. We tested the hypothesis part...
Abstract We previously reported that cannabidiol (CBD), one of the Cannabis sativa-derived cannabinoid compounds and a potent immunosuppressive agent, increased CD25 FOXP3 expression on CD4+ cells under “ultrasuboptimal” T cell stimulation (1 nM PMA/0.0125 μM Ionomycin, designated “Us/o”). also observed CBD IL-10 il10 mRNA Us/o stimulation. Thus, we tested hypothesis CBD-induced CD25+ FOXP3+ are functional Tregs. First, determined was induced CD4-enriched in response to (10 μM) plus...
Abstract We previously reported that cannabidiol (CBD), one of the Cannabis sativa-derived cannabinoids, induced functional CD4+CD25+FOXP3+ Tregs in response to low level stimulation PMA/Io. CBD increased CD25+FOXP3+ cells CD4+, CD4+CD25+, and CD4+CD25− T cells, as well CD4+ derived from FOXP3-GFP mice. cell conditions were suboptimal PMA/Io (4 nM/0.05 μM, S/o) ultrasuboptimal (1 nM/0.0125 Us/o). also observed + Us/o IL-2, IL-10 TGF-β1 immunomodulatory cytokines. Here, we measured effect or...
ABSTRACT Aim Abdominal aortic aneurysms (AAA) is a life-threatening weakening and expansion of the abdominal aorta due to inflammatory cell infiltration gradual degeneration extracellular matrix (ECM). There are no pharmacological therapies treat AAA. We tested hypothesis that nanoparticle (NP) therapy targets degraded elastin delivers anti-inflammatory, anti-oxidative, ECM stabilizing agent, pentagalloyl glucose (PGG) will reverse advance stage aneurysm in an elastase-induced mouse model...