A5028125537- RNA and protein synthesis mechanisms
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- MicroRNA in disease regulation
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Tissue Engineering and Regenerative Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Economic and Financial Impacts of Cancer
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Protease and Inhibitor Mechanisms
- Advanced Computing and Algorithms
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Renal and related cancers
- Blood Coagulation and Thrombosis Mechanisms
- Bacteriophages and microbial interactions
Indiana University – Purdue University Indianapolis
2015-2022
Indiana University School of Medicine
2015-2022
Scripps Research Institute
2007
Expanding the genetic code DNA and RNA are naturally composed of four nucleotide bases that form hydrogen bonds in order to pair. Hoshika et al. added an additional synthetic nucleotides produce eight-letter generate so-called hachimoji DNA. Coupled with engineered T7 polymerase, this expanded alphabet could be transcribed into RNA. Thus, new forms add information density biopolymers can generated may useful for future biological applications. Science , issue p. 884
In mammalian cells, specific aminoacyl-transfer RNA (tRNA) synthetases have cytokine functions that require interactions with partners outside of the translation apparatus. Little is known about these and how they facilitate expanded link protein to other cellular pathways. For example, an alternative splice fragment tryptophanyl-tRNA synthetase (TrpRS) a similar natural proteolytic are potent angiostatic factors act through vascular endothelial-cadherin receptor Akt signaling pathway. Here...
A critical function of the telomere is to disguise chromosome ends from cellular recognition as double strand breaks, thereby preventing aberrant fusion events. Such end-to-end fusions are known initiate genomic instability via breakage-fusion-bridge cycles. Telomere dysfunction and other forms assault likely result in misregulation genes involved growth control, cell death, senescence pathways, lowering threshold malignancy drive disease progression. Shortened telomeres anaphase bridges...
Abstract Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Liver metastasis major CRC patient mortality, occurring in 60% patients with no effective therapies. Although studies have indicated role miRNAs CRC, an in-depth miRNA expression analysis essential to identify clinically relevant and understand their potential targeting liver metastasis. Here we analyzed expressions 405 tumors from publicly available colorectal genome sequencing project database....
Extensive portions of the human genome have unknown function, including those derived from transposable elements. One such element, DNA transposon Hsmar1, entered primate lineage approximately 50 million years ago leaving behind terminal inverted repeat (TIR) sequences and a single intact copy Hsmar1 transposase, which retains its ancestral TIR-DNA-binding activity, is fused with lysine methyltransferase SET domain to constitute chimeric SETMAR gene. Here, we provide structural basis for...
Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event carcinogenesis human solid tumors. Recent findings have established presence telomere fusions breast prostate malignancies; however, onset this mechanism during progression other cancers not well understood. Herein, we explored dynamics patient-derived epithelial ovarian (OC), a malignancy characterized by multiple distinct subtypes, extensive molecular...