A5087740475- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Advances in Oncology and Radiotherapy
- AI in cancer detection
- MRI in cancer diagnosis
- Management of metastatic bone disease
- Radiology practices and education
- Social Media in Health Education
- Global Cancer Incidence and Screening
- Animal testing and alternatives
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Diversity and Career in Medicine
- Prostate Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Breast Cancer Treatment Studies
Western General Hospital
2020-2023
Edinburgh Cancer Research
2020-2023
Cancer Research UK
2017-2020
Addenbrooke's Hospital
2017-2020
University of Cambridge
2017-2020
Cambridge University Hospitals NHS Foundation Trust
2017-2020
For the first time, delivered dose to rectum has been calculated and accumulated throughout course of prostate radiotherapy using megavoltage computed tomography (MVCT) image guidance scans. Dosimetric parameters were linked with toxicity test hypothesis that is a stronger predictor than planned dose. Dose-surface maps (DSMs) rectal wall automatically generated from daily MVCT scans for 109 patients within VoxTox research programme. Accumulated-DSMs, representing total dose, planned-DSMs,...
The impact of weight loss and anatomical change during head neck (H&N) radiotherapy on spinal cord dosimetry is poorly understood, limiting evidence-based adaptive management strategies.133 H&N patients treated with daily mega-voltage CT image-guidance (MVCT-IG) TomoTherapy, were selected. Elastix software was used to deform planning scan SC contours MVCT-IG scans, accumulate dose. Planned (DP) delivered (DA) D2% (SCD2%) compared. Univariate relationships between irradiation strategy...
Background and PurposeAssociations between dose rectal toxicity in prostate radiotherapy are generally poorly understood. Evaluating spatial distributions to the wall (RW) may lead improvements dose-toxicity modelling by incorporating geometric information, masked dose-volume histograms. Furthermore, predictive power be strengthened effects of interfraction motion into delivered calculations.Here we interrogate 3D for patients with without identify subregions at risk (SRR), compare...
Some patients with breast cancer treated by surgery and radiation therapy experience clinically significant toxicity, which may adversely affect cosmesis quality of life. There is a paucity validated clinical prediction models for toxicity. We used machine learning (ML) algorithms to develop optimise model acute desquamation after whole external beam in the prospective multicenter REQUITE cohort study.Using demographic treatment-related features (m = 122) from (n 2058) at 26 centers, we...
The VoxTox research programme has applied expertise from the physical sciences to problem of radiotherapy toxicity, bringing together engineering, mathematics, high energy physics (including Large Hadron Collider), medical and radiation oncology. In our initial cohort 109 men treated with curative for prostate cancer, daily image guidance computed tomography (CT) scans have been used calculate delivered dose rectum, as distinct planned dose, using an automated approach. Clinical toxicity...
The irradiation of sub-regions the parotid has been linked to xerostomia development in patients with head and neck cancer (HNC). In this study, we compared classification performance radiomics features calculated on clinically relevant de novo glands HNC patients.All (N = 117) were treated TomoTherapy 30-35 fractions 2-2.167 Gy per fraction daily mega-voltage-CT (MVCT) acquisition for image-guidance purposes. Radiomics 123) extracted from MVCTs whole gland nine sub-regions. changes feature...
While core to the scientific approach, reproducibility of experimental results is challenging in radiomics studies. A recent publication identified features that are predictive late irradiation-induced toxicity head and neck cancer (HNC) patients. In this study, we assessed generalisability these findings.The procedure described question was applied a cohort 109 HNC patients treated with 50-70 Gy 20-35 fractions using helical radiotherapy although there were inherent differences between two...
Autosegmentation of image guidance (IG) scans is crucial for streamlining and optimising delivered dose calculation in radiotherapy. By accounting interfraction motion, daily can be accumulated incorporated into automated systems adaptive IG challenging due to poorer quality than typical planning kilovoltage computed tomography (kVCT) systems, the resulting reduction soft tissue contrast regions such as pelvis makes organ boundaries less distinguishable. Current autosegmentation solutions...
ESTRO 36 _______________________________________________________________________________________________ transformation parameters, we created 'voxel histories' for the spinal cord relative to planning CT, and calculated delivered dose.Maximum planned dose (D2%) were then compared. ResultsA summary of auto-contouring algorithm performance is shown in Table 1.Auto-contouring appeared comparable manual segmentation, proceeded calculate dose.These results are Figure 1 (A-C).Fig. 1A shows a...
ConclusionA NTCP model based on delivered dose to SRR0.01 and HTN was generated validated for RB.External validation would be desirable.FEA provides a more anatomically representative tool accumulation than planar homogeneous expansion.Improved toxicity prediction could useful decision making in adaptive RT.