A5065607090- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Sleep and related disorders
- Sleep and Wakefulness Research
- Patient Safety and Medication Errors
- Genetics, Aging, and Longevity in Model Organisms
- Plant and animal studies
- Cardiac, Anesthesia and Surgical Outcomes
- Hospital Admissions and Outcomes
- Neuroendocrine regulation and behavior
- Thermal Regulation in Medicine
- Insect and Pesticide Research
- Thermoregulation and physiological responses
- Anesthesia and Neurotoxicity Research
- Infrared Thermography in Medicine
- Medical History and Innovations
- Climate Change and Health Impacts
- Gut microbiota and health
- Dietary Effects on Health
- Birth, Development, and Health
- Marine and coastal plant biology
- Light effects on plants
- Olfactory and Sensory Function Studies
University of Auckland
2014-2025
European Society of Anaesthesiology
2014
Plant & Food Research
2013
Significance The question of the computational capacities brains widely separated genera animals is interest to behavioral biologists, comparative psychologists, neuroscientists, philosophers mind, and—we believe—much scientific community. Half a century ago, claim that any nonhuman animal had cognitive map was deeply controversial. If true, it greatly favored theory as opposed an antirepresentational behaviorist theory. Now well established by and neurobiological evidence rodents have...
Following general anesthesia, people are often confused about the time of day and experience sleep disruption fatigue. It has been hypothesized that these symptoms may be caused by anesthesia affecting circadian clock. The clock is fundamental to our well-being because it regulates almost all aspects daily biochemistry, physiology, behavior. Here, we investigated effects most common anesthetic, isoflurane, on perception using honeybee ( Apis mellifera) as a model. A 6-h daytime anesthetic...
Elongated landscape features like forest edges, rivers, roads or boundaries of fields are particularly salient landmarks for navigating animals. Here we ask how honeybees learn such structures and they used during their homing flights after being released at an unexpected location (catch-and-release paradigm). The experiments were performed in two landscapes that differed with respect to overall structure: a rather feature-less landscape, one rich close far distant landmarks. We tested three...
Summary We implemented the World Health Organization surgical safety checklist at Auckland City Hospital from November 2007. hypothesised that would reduce postoperative mortality and increase days alive out of hospital, both measured to 90 days. compared outcomes for cohorts who had surgery during 18‐month periods before vs. after implementation. also analysed 9 years included these (July 2004–December 2013). 9475 patients in period 10,589 afterwards. 57,577 2004 2013. Mean number hospital...
The immune response exhibits strong circadian rhythmicity, with enhanced bacterial clearance often synchronized an organism’s active phase. Despite providing the bulk of cellular antibacterial defense, neutrophil clockwork is poorly understood. Here, we used larval zebrafish to explore role clock genes in neutrophils during infection. Per2 was required for reactive oxygen species (ROS) production and killing by enhancing infection-responsive expression high-mobility group box 1a ( hmgb1a )....
This clinical methods comparison study describes the difference between light levels measured at wrist (Actiwatch-L) and eye (Daysimeter) in a postoperative in-patient population. The mean two devices was less than 10 lux 5000 lux. Agreement found to decrease as eye-level exposure increased. Measurements level of or more corresponded greater 100 eye- wrist-level measurements also appears be influenced by time day. During day, measurement differences were on average 50 higher level, whereas...
Summary It is notoriously difficult to obtain evidence from clinical randomised controlled trials for safety innovations in healthcare. We have developed a research design using simulation the evaluation of initiatives anaesthesia. used standard and modified scenario human‐patient simulator, involving potentially life‐threatening problem requiring prompt attention – either cardiac arrest or failure oxygen supply. The scenarios involved distractions such as loud music, demanding uncooperative...
Study Objectives To determine the prevalence of self-reported circadian-related sleep disorders, medication and melatonin use in New Zealand blind population. Design A telephone survey incorporating 62 questions on habits together with validated questionnaires quality, chronotype seasonality. Participants were grouped into: (i) 157 reduced conscious perception light (RLP); (ii) 156 visually impaired no reduction (LP) matched for age, sex socioeconomic status, (iii) fully-sighted controls...
The circadian clock, which evolved to help organisms harmonize physiological responses external conditions (such as the light/dark cycle, LD), is emerging an important regulator of immune response infection. Gaining a complete understanding how clock influences cell requires animal models that permit direct observation these processes within intact host. Here, we investigated use larval zebrafish, powerful live imaging system, new model study impact fundamental zeitgeber, light, on innate...
ABSTRACT General anaesthesia administered during the day has previously been shown to phase shift honey bee clock. We describe a response curve for bees (n=105) six hour isoflurane anaesthesia. The PRC is "weak" with delay portion (maximum of –1.88 hours, circadian time 0 – 3) but no advance zone. isoflurane-induced shifts observed here are in direct opposition those light. Furthermore, concurrent administration light and abolishes that occur alone. Light may thus provide means reducing...
Summary In a prospective, observational trial, we investigated the influence of time day on duration neuromuscular blockade (NMB) elicited by rocuronium. Forty‐nine patients scheduled for surgery between 08:00 and 02:00 were enrolled after giving written informed consent. Time to recovery was measured following three doses: (1) fat‐free‐mass (FFM) related induction dose (0.6 mg.kg −1 : n = 47); (2) maintenance (20% dose: 42); (3) standard 10‐mg (n 35). The extent NMB dependent administration...
How animals precisely time behaviour over the lunar cycle is a decades-old mystery. Experiments on diverse species show this to be endogenous and under clock control but mechanism has remained elusive. We present new experimental analytical techniques test hypotheses for semilunar that rhythm of foraging in intertidal isopod, Scyphax ornatus, can shifted by manipulating lengths light/dark tidal cycles. Using light T-cycles (Tcd) resultant beat period undergoes shifts from 14.79 days 6.47 T =...
Following general anaesthesia (GA), patients frequently experience sleep disruption and fatigue, which has been hypothesized to result at least in part by GA affecting the circadian clock. Here, we provide first comprehensive time-dependent analysis of effects commonly administered inhalational anaesthetic, isoflurane, on murine clock, analysing its (a) behavioural locomotor rhythms (b) PER2::LUC expression suprachiasmatic nuclei (SCN) mouse brain. Behavioural phase shifts elicited exposure...
The importance of the circadian clock for control behavior and physiology is well established but how when it develops not fully understood. Here initial expression pattern key gene period was recorded in Drosophila from embryos vivo, using transgenic luciferase reporters. PERIOD presumptive central-clock dorsal neurons started to oscillate embryo constant darkness. In behavioral experiments, a single 12-h light pulse given during embryonic stage synchronized adult activity rhythms, implying...
The importance of the circadian clock for regulation behaviour and physiology, molecular control these rhythms by a set genes are well defined. deteriorates with advancing age but mechanism underlying is unclear. Here we recorded expression two key in young, middle-aged old Drosophila using transgenic luciferase lines reporting period timeless vivo. We report novel marker imminent death TIMELESS. In days immediately preceding TIMELESS increased to at least 150% previous acrophase values...
The authors report a phase response curve (PRC) for individual honey bees (Apis mellifera) to single 1-h light pulses (1000 lux) using an Aschoff Type 1 protocol (n = 134). bee PRC is weak (Type 1) with maximum advance of 1.5 h between circadian time (CT) 18 and 3 delay CT 12 18. This the first published provides important resource chronobiologists researchers. It may also have practical applications what economically species frequently transported across different zones. (Author...
General anaesthesia (GA) is implicated as a cause of postoperative sleep disruption and fatigue with part the disturbance being attributed to shift circadian clock. In this study, Drosophila melanogaster was used model determine how Isoflurane affects clock at behavioural molecular levels. We measured response both these levels caused by different durations concentrations time 4 (CT4). Once characterized, we held duration concentration constants (at 2% in air for 6 h) calculated phase...
There is potential for heat loss and hypothermia during anesthesia also hyperthermia if conservation active warming measures are not accurately titrated. Accurate temperature monitoring particularly important in procedures which the patient actively cooled then rewarmed such as cardiopulmonary bypass surgery (CPB). We simultaneously measured core, nasopharyngeal, brachial artery temperatures to investigate last named a peripheral site. Ten patients undergoing hypothermic CPB were...