A5008689593- Gut microbiota and health
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Infant Nutrition and Health
- Oral microbiology and periodontitis research
- Digestive system and related health
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Gastrointestinal motility and disorders
- Escherichia coli research studies
- Salivary Gland Disorders and Functions
- Advanced Drug Delivery Systems
- Liver Disease Diagnosis and Treatment
- Health, psychology, and well-being
- Reproductive tract infections research
- Effects of Radiation Exposure
- Inhalation and Respiratory Drug Delivery
- Drug-Induced Hepatotoxicity and Protection
- Intensive Care Unit Cognitive Disorders
- Fecal contamination and water quality
- Ginger and Zingiberaceae research
- Thermal Regulation in Medicine
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Food composition and properties
Anatech
2018-2023
Advanced Materials and Technologies (Slovenia)
2023
Università Cattolica del Sacro Cuore
2004-2008
Background/Objectives: Minimal hepatic encephalopathy (MHE) is a clinical condition characterized by neurological impairments, including brain inflammation, arising from the accumulation of toxic metabolites associated with liver dysfunction and leaky gut. This study investigated pharmacological activity new phytocomplex extracted red orange by-products (AL0042) using hydrodynamic cavitation consisting mixture pectin, polyphenols, essential oils. Methods: Preliminary in vitro studies...
The aim of this study was to identify a link between the total amount breast milk oligosaccharides and faecal microbiota composition newborns at end first month life, with special attention paid bifidobacteria, establish role, if any, different in determining gut composition.Milk oligosaccharide groups were identified by high-performance anion exchange chromatography analysis. DPCRNA from newborns' samples 30 days life isolated processed polymerase chain reaction analyses that allow...
Rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (IBS), mainly due to ability act on IBS pathogenesis, through the influence gut microbiota. The aim present study was assess, by biomolecular tools, rifaximin active modulation exerted microbiota non-constipated patients. Fifteen subjects were treated 550 mg three times day 14 days. Stool samples collected before starting treatment, at end it, and after 6-week washout period....
Abstract Among the emerging issues in probiotic safety, possible presence of pks , a gene cluster synthetizing genotoxin known as colibactin, is one most alarming. Indeed, indigenous E. coli strain -positive are found 60% patients with colorectal cancer, and widely used -based probiotic, Nissle 1917 (DSM 6601), -positive. Starting from 25 potential candidates selected by screening infant stool samples, we have an (named 5C, deposited LMG S-33222) belonging to phylotype A having serovar...
The objective of the study was to investigate effects a galacto-oligosaccharides (GOS)-supplemented formula on intestinal microbiota in healthy term infants, with specific consideration for gastrointestinal symptoms as colic, stool frequency and consistency, regurgitation.This randomized, double-blind, controlled, parallel-group clinical trial performed simultaneously by 6 centers Italy. Three groups were considered: breastfed, formula-fed, GOS-supplemented formula-fed infants. Formula-fed...
Supplementing kindergarten children during a cold season with prebiotic inulin-type fructans product shorter and longer fructan chains has been shown to reduce febrile episodes requiring medical attention lower the incidence of sinusitis. These beneficial effects may be connected specific modulation children’s gut microbiota. By applying quantitative qualitative microbiota analysis this study aimed at characterising composition exploring intervention on 24-weeks antibiotic treatment in...
The gut microbiota is altered in epilepsy and emerging as a potential target for new therapies. We studied the effects of rifaximin, gastrointestinal tract-specific antibiotic, on seizures neuropathology alterations its mouse model temporal lobe (TLE). Epilepsy was induced by intra-amygdala kainate injection causing status epilepticus (SE) C57Bl6 adult male mice. Sham mice were injected with vehicle. Two cohorts SE fed rifaximin-supplemented diet 21 days, starting either at 24 h post-SE...
Inulin-type fructans used in formula have been shown to promote microbiota composition and stool consistency closer those of breastfed infants beneficial effects on fever occurrence, diarrhea, incidence infections requiring antibiotic treatment infants.The primary study aim was explore whether prophylactic supplementation with prebiotic is able influence the frequency infectious diseases kindergarten children during a winter period. A secondary objective ascertain effect intestinal...
To assess the effects of consumption psyllium seed husk on fecal bifidobacteria in healthy women and ability to metabolize vitro.Poor microbiologic evidences are nowadays available concerning promote growth human gut.Eleven consumed 7.0 g/d for 1 month. Viability feces was assessed at different time points.In vivo results showed that average content viable not significantly affected even if counts were found increase after treatment 6 out 11 having low initial concentration. In vitro trials...
In patients with Parkinson's disease (PD), constipation is common, and it appears in a prodromal stage before the hallmark motor symptoms. The present study aimed to investigate whether Velusetrag, selective 5‑HT4 receptor agonist, may be suitable candidate improve intestinal motility mouse model of PD. Five months old PrP human A53T alpha-synuclein transgenic (Tg) mice, which display severe along decreased colonic cholinergic transmission already at 3 months, were treated daily drug for 4...
Crohn’s and ulcerative colitis are common conditions associated with inflammatory bowel disease as well intestinal flora epithelial barrier dysfunction. A novel fermented Lactobacillus brevis (AL0035) herein assayed in a trinitro benzene sulfonic acid (TNBS)-induced mice model after oral administration significantly counteracted the body weight loss improves activity index histological injury scores. AL0035 decreased mRNA protein expression of different pro-inflammatory cytokines (TNFalpha,...
Stress affects the immune system and intestinal microbiota composition can lead to imbalance between pro- anti-inflammatory cytokines or uncontrolled production of cytokines. The effect emotional stress on secretory IgA levels also indicates that decreases mucosal integrity. Our aim was evaluate whether a probiotic product (Lactoflorene® Plus) prevent alterations in response associated with self-reported composition. Healthy adult volunteers who psychological were enrolled randomised into...
Recent investigations have highlighted, both experimentally and clinically, that probiotic strains equipped with arabinofuranosidase, in particular
Periodontitis is a common disorder that leads to the loss of both tooth and personal well-being, contributing worsen risk for metabolic cardiovascular diseases. Recently, probiotics, characterized by rapid oral dispersion, have been topically used. Here, we present data mucoadhesive gel containing capable ensuring slow release bacteria prevent treat periodontitis.An original (AL0005) anhydrous food grade, loaded with blend lactobacilli plants' dry extracts, has assayed.The kinetics bacterial...
Castellazzi, Annamaria PhD*; Tagliacarne, Sara Carlotta Soldi, PhD†; Perna, Simone PhD‡; Ziviani, Luigi MD§; Milleri, Stefano Montagna, Lorenza BSc*; Valsecchi, Chiara MSc∥ Author Information
We present the genome sequence of
Pelvic radiation disease (PRD), a frequent side effect in patients with abdominal/pelvic cancers treated radiotherapy, remains an unmet medical need. Currently available preclinical models have limited applications for the investigation of PRD pathogenesis and possible therapeutic strategies. In order to select most effective irradiation protocol induction mice, we evaluated efficacy three different locally fractionated X-ray exposures. Using selected (10 Gy/day × 4 days), assessed through...
This study was designed to evaluate the effects of a gluco-oligosaccharide (GOS), as an alternative growth promoters in piglets, on: performance, blood parameters and morphological characteristics intestinal tract. Four week old weaned piglets (n=128) (7.2 ± 1.04 kg l.w.) were divided into four groups fed for 77 days on different diets follows: 1.- Basal diet (CTR); 2.- supplemented with 2% GOS; 3.- chlortetracycline spiramicine at 1000 400 mg/ kg, respectively, 14 then CTR basal (CTRM); or...
: An innovative and stable probiotics-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated periodontal diseases. Tau-Marin was tested against some pathogenic bacteria, belonging so-called "red complex", recognized as most important pathogens in plaque specimens, adherent epithelial lining of pockets. A detailed physico-chemical profile AL0020 its vitro efficacy protecting activity bacteria well...
Abstract In patients with Parkinson’s disease (PD), constipation is common, and it appears in a prodromal stage before the hallmark motor symptoms. The present study aimed to investigate whether Velusetrag, selective 5‑HT4 receptor agonist, may be suitable candidate improve intestinal motility mouse model of PD. Five months old PrP human A53T alpha-synuclein transgenic mice, which display severe along decreased colonic cholinergic transmission already at 3 months, were treated daily drug for...
An innovative and stable probiotic-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated periodontal diseases. Tau-Marin gel, prepared anhydrous ingredients prevent replication of bacteria ensure good stability over time, was tested against some pathogenic bacteria, belonging so-called “red complex”, recognized as most important pathogens in plaque specimens, adherent epithelial lining pockets. This lipogel vitro, a...