A5082628752- Gut microbiota and health
- Inflammatory Bowel Disease
- Microscopic Colitis
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Drug Transport and Resistance Mechanisms
- Esophageal Cancer Research and Treatment
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Diet, Metabolism, and Disease
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- Probiotics and Fermented Foods
- Bioinformatics and Genomic Networks
- Meta-analysis and systematic reviews
- Autophagy in Disease and Therapy
- Metastasis and carcinoma case studies
- Insect and Arachnid Ecology and Behavior
- Pharmacological Effects of Natural Compounds
- HIV/AIDS Impact and Responses
Technical University of Munich
2018-2025
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2020-2025
Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside proximity Lgr5 + intestinal stem cells (ISC) mitochondria critical for ISC-renewal differentiation. Here, we characterise ISC appearance under conditions describe role mitochondrial niche-maintenance. Design Ileal tissue samples from patients with CD, mouse models dysfunction (Hsp60 Δ/ΔISC ) CD-like ileitis...
Abstract Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome analysis longitudinal cohort Crohn’s disease patients undergoing autologous hematopoietic stem cell transplantation, investigational therapy that induces drug free remission in subset patients. Via comparison who responded maintained remission, but experienced relapse did not respond therapy, identify shared functional signatures...
Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via butyrate production. Human bariatric surgery data suggest the gut-brain axis is also involved this process, but underlying mechanisms remain unknown.We compared effect of fecal transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin (SERT) binding as well stable isotope-determined...
Abstract Transition from traditional high-fiber to Western diets in urbanizing communities of Sub-Saharan Africa is associated with increased risk non-communicable diseases (NCD), exemplified by colorectal cancer (CRC) risk. To investigate how urbanization gives rise microbial patterns that may be amenable dietary intervention, we analyzed diet intake, fecal 16 S bacteriome, virome, and metabolome a cross-sectional study healthy rural urban Xhosa people (South Africa). Urban individuals had...
Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt mitochondrial function in the epithelium by deleting chaperone, heat shock protein 60 (Hsp60
In addition to their important role in fat digestion, bile acids are increasingly being used as markers for various diseases. The large diversity of results from the conversion primary and conjugated into secondary by deconjugation dehydroxylation reactions mediated intestinal microbiota. Here, we describe a fast sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method absolute quantitation 45 human or mouse feces combination with simple workup extraction procedure. Method...
Abstract Background Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on presence microbial triggers. Increased abundance unknown Clostridiales microscopic detection filamentous structures close to epithelium Tnf ΔARE mice, a mouse model ileitis pointed towards segmented bacteria (SFB), commensal mucosal adherent bacterium involved ileal inflammation. Results We show that SFB strongly correlates severity two...
Background & Aims While hormone secretion from enteroendocrine cells (EECs) and their functions in digestion metabolism are well studied, the role of EECs intestinal inflammation is virtually unknown. In inflammatory bowel diseases (IBD), a contribution to pathogenesis indicated by autoantibodies affecting EEC function general disease symptoms like insulin resistance altered motility. Particularly, L cell-derived glucagon-like peptide 1 (GLP-1) exerts direct effects on intraepithelial...
Abstract Background and Aims Crohn’s disease [CD] is a major subtype of inflammatory bowel diseases [IBD] with increasing incidence prevalence. Results studies using available small large animal models are often poorly translatable to patients, few CD show intestinal pathology. Due its similarities humans, the pig has emerged as highly suitable translational model, particularly for testing novel nutritional technological interventions. Our goal was develop physiologically relevant porcine...
The incidence of Barrett esophagus (BE) and Gastroesophageal Adenocarcinoma (GEAC) correlates with obesity a diet rich in fat. Bile acids (BA) support fat digestion undergo microbial metabolization the gut. farnesoid X receptor (FXR) is an important modulator BA homeostasis. capacity inhibiting cancer-related processes when activated, make FXR appealing therapeutic target. In this work, we assess role on microbiota-BA axis evaluate disease progression.
Background Personalized medicine requires finding relationships between variables that influence a patient’s phenotype and predicting an outcome. Sparse generalized canonical correlation analysis identifies different groups of variables. This method establishing model the expected interaction those Describing these interactions is challenging when relationship unknown or there no pre-established hypothesis. Thus, our aim was to develop find microbiome host transcriptome data relevant...
Esophageal adenocarcinoma (EAC) is mostly prevalent in industrialized countries and has been associated with obesity, commonly linked a diet rich fat refined sugars containing high fructose concentrations. In meta-organisms, dietary components are digested metabolized by the host its gut microbiota. Fructose shown to induce proliferation cell growth pancreas colon cancer lines also alter previous study L2-IL-1B mouse model, we showed that high-fat (HFD) accelerated EAC progression from...