A5059940902- Inflammatory Bowel Disease
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Digestive system and related health
- Clostridium difficile and Clostridium perfringens research
- Heat shock proteins research
- Diet and metabolism studies
- Colorectal Cancer Treatments and Studies
Technical University of Munich
2016-2024
Abstract Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in function are implicated inflammatory and neoplastic diseases the gastrointestinal tract. Here we report that mitochondrial plays a critical role maintaining Using cell (IEC)-specific mouse models, show loss HSP60, chaperone, activates unfolded protein response (MT-UPR) results dysfunction. HSP60-deficient crypts display proliferation, accompanied by release WNT10A RSPO1. Sporadic failure...
Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside proximity Lgr5 + intestinal stem cells (ISC) mitochondria critical for ISC-renewal differentiation. Here, we characterise ISC appearance under conditions describe role mitochondrial niche-maintenance. Design Ileal tissue samples from patients with CD, mouse models dysfunction (Hsp60 Δ/ΔISC ) CD-like ileitis...
Abstract Background Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on presence microbial triggers. Increased abundance unknown Clostridiales microscopic detection filamentous structures close to epithelium Tnf ΔARE mice, a mouse model ileitis pointed towards segmented bacteria (SFB), commensal mucosal adherent bacterium involved ileal inflammation. Results We show that SFB strongly correlates severity two...
Background & Aims While hormone secretion from enteroendocrine cells (EECs) and their functions in digestion metabolism are well studied, the role of EECs intestinal inflammation is virtually unknown. In inflammatory bowel diseases (IBD), a contribution to pathogenesis indicated by autoantibodies affecting EEC function general disease symptoms like insulin resistance altered motility. Particularly, L cell-derived glucagon-like peptide 1 (GLP-1) exerts direct effects on intraepithelial...
Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated cancer (CAC). We previously linked the endoplasmic reticulum unfolded protein response (UPRER) signal transducer activating transcription 6 (ATF6) with spontaneous microbiota-dependent colonic adenoma development mice expressing epithelial-specific activated ATF6 (nATF6IEC). To investigate IBD-related factors ATF6-mediated tumorigenesis, we crossed tumor-free...
Abstract Background Crohn’s disease (CD)-like inflammation in TNFdeltaARE mice (ARE) is triggered by dysbiotic gut microbial communities. Similar to the therapeutic effect of exclusive enteral nutrition CD, dietary intervention using semi-synthetic experimental diet prevents development ARE mice. The aim this study identify causal cues responsible for CD-like and dissect protective role Methods Bacterial communities wildtype (WT) were profiled 16S rRNA gene sequencing, FISH qPCR. Germfree WT...
ABSTRACT Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on presence microbial triggers. Increased abundance unknown Clostridiales microscopic detection filamentous structures close to epithelium Tnf ΔARE mice pointed towards segmented bacteria (SFB), a commensal well-known induce maturation Th17 cell-derived immune responses that highly implicated pathogenesis IBD. We show SFB strongly correlates severity ileal...