A5088731012- Computational Drug Discovery Methods
- Animal testing and alternatives
- Chemistry and Chemical Engineering
- Effects and risks of endocrine disrupting chemicals
- Nanoparticles: synthesis and applications
- Trace Elements in Health
- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Electrochemical Analysis and Applications
- History and advancements in chemistry
- Chemical Safety and Risk Management
- Aluminum toxicity and tolerance in plants and animals
- Health Systems, Economic Evaluations, Quality of Life
- Machine Learning in Materials Science
- Delphi Technique in Research
- Immunotoxicology and immune responses
- Dyeing and Modifying Textile Fibers
- Pharmacogenetics and Drug Metabolism
- Cell Image Analysis Techniques
- Textile materials and evaluations
- Pharmaceutical and Antibiotic Environmental Impacts
- Advancements in Transdermal Drug Delivery
- Multicomponent Synthesis of Heterocycles
- Bioinformatics and Genomic Networks
Liverpool John Moores University
2013-2022
Joint Research Centre
2016-2019
ABS Consulting (United States)
2019
European Commission
2019
Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute
2002-2003
German Orient Foundation
2001
In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for regulatory submissions, as assessing chemicals under REACH well the ICH M7 guideline drug impurities. There are a number obstacles performing an IST assessment, including uncertainty how assessment associated expert review should be performed or what fit purpose, lack confidence that results will accepted by colleagues, collaborators...
An increasing number of manufactured nanomaterials (NMs) are being used in industrial products and need to be registered under the REACH legislation. The hazard characterisation all these forms is not only technically challenging but resource time demanding. use non-testing strategies like read-across deemed essential assure assessment NMs due at lower cost. fact that based on structural similarity substances represents an additional difficulty for as general their structure unequivocally...
As the basis for managing risks of chemical exposure, Chemical Risk Assessment (CRA) process can impact a substantial part economy, health hundreds millions people, and condition environment. However, number properly assessed chemicals falls short societal needs due to lack experts evaluation, interference third party interests, sheer volume potentially relevant information on from disparate sources. In order explore ways in which computational methods may help overcome this discrepancy...
The current landscape of Adverse Outcome Pathways (AOPs) provides a means organizing information relating to the adverse effects elicited following exposure chemicals. As such, AOPs are an excellent driver for development and application in silico models predictive toxicology allowing direct relationship between chemistry be established. Information may extracted from support creation (quantitative) structure-activity relationships [(Q)SARs] increase confidence grouping read-across. Any part...
Analysis of trends in nanotoxicology data and the development driven models for nanotoxicity is facilitated by reporting using a standardised electronic format. ISA-TAB-Nano has been proposed as such However, order to build useful datasets according this format, variety issues be addressed. These include questions regarding exactly which (meta)data report how them. The current article discusses some challenges associated with use presents set resources designed facilitate manual creation...
Capillary zone electrophoresis, with its high resolution capability in the separation of different compounds, is well suited for investigation metal-containing proteins, especially when elemental detection conducted using hyphenated inductively coupled plasma-mass spectrometry. A major problem proteins body fluids caused by effects sample matrix composition. The migration time varies significantly, depending on nature matrix. Electropherograms are consequently difficult to compare and peak...
Automation is universal in today's society, from operating equipment such as machinery, factory processes, to self-parking automobile systems. While these examples show the efficiency and effectiveness of automated mechanical procedures that support chemical risk assessment process are still their infancy. Future human safety assessments will rely increasingly on use models, physiologically based kinetic (PBK) dynamic models virtual cell assay (VCBA). These biologically-based be coupled with...
In the human body, there exists over 200 different cell types, which differ in size and structure have specialised functions organism. Therefore it can be assumed that these cells also contain proteins necessary to carry out respective functions. This supposed metalloprotein composition organs cannot demonstrated by determination of total element concentrations. investigations protein-bound forms elements were achieved speciation analysis: The biomolecules separated exclusion chromatography...