A5005049952- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Virus-based gene therapy research
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Reproductive System and Pregnancy
Cincinnati Children's Hospital Medical Center
2018-2022
University of Cincinnati
2018
Pregnancy and parturition are intricately regulated to ensure successful reproductive outcomes. However, the factors that control gestational length in humans other anthropoid primates remain poorly defined. Here, we show endogenous retroviral long terminal repeat transposon-like human element 1B (THE1B) selectively controls placental expression of corticotropin-releasing hormone (CRH) that, turn, influences birth timing. Placental CRH subsequently prolonged were found two independent...
Postpartum depression (PPD) affects up to 20% of mothers and has negative consequences for both mother child. Although exposure psychosocial stress during pregnancy abnormalities in the hypothalamic pituitary adrenal (HPA) axis have been linked PPD, molecular changes brain that contribute this disease remain unknown. This study utilized a novel chronic paradigm (CGS) investigate effects on maternal behavior, neuroendocrine function, gene expression regulators HPA early postpartum period....
Abstract Prenatal stress (PS) is associated with increased vulnerability to affective disorders. Transplacental glucocorticoid passage and stress-induced maternal environment alterations are recognized as potential routes of transmission that can fundamentally alter neurodevelopment. However, molecular mechanisms underlying aberrant emotional outcomes or the individual contributions intrauterine versus play in shaping these remain unknown. Here, we report anxiogenic behaviors, anhedonia,...
ABSTRACT Prenatal stress (PS) is associated with increased vulnerability to affective disorders. Transplacental glucocorticoid passage and stress-induced maternal environment alterations are recognized as potential routes of transmission that can fundamentally alter neurodevelopment. However, molecular mechanisms underlying aberrant emotional outcomes or the individual contributions intrauterine versus play in shaping these remain unknown. Here, we report anxiogenic behaviors, anhedonia,...