A5090483961- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Poxvirus research and outbreaks
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- Cervical Cancer and HPV Research
- Viral-associated cancers and disorders
- Data-Driven Disease Surveillance
- Syphilis Diagnosis and Treatment
- Mental Health and Patient Involvement
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Oral and Maxillofacial Pathology
- COVID-19 Clinical Research Studies
- Colorectal and Anal Carcinomas
- Family Caregiving in Mental Illness
- Sex work and related issues
- Emergency and Acute Care Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oropharyngeal Anatomy and Pathologies
- HIV/AIDS oral health manifestations
Johns Hopkins Medicine
2011-2025
Johns Hopkins University
2011-2025
University of Alabama at Birmingham
2025
Vanderbilt University Medical Center
2006-2024
Office of Infectious Diseases
2021
St. Columcille's Hospital
2017-2019
Brookhaven National Laboratory
2018
Cornell University
2018
Dementia Australia
2017
Centers for Disease Control and Prevention
1995-2014
People living with human immunodeficiency virus (HIV) may have numerous risk factors for acquiring coronavirus disease 2019 (COVID-19) and developing severe outcomes, but current data are conflicting.Health-care providers enrolled consecutively, by nonrandom sampling, people HIV (PWH) lab-confirmed COVID-19, diagnosed at their facilities between 1 April July 2020. Deidentified were entered into an electronic Research Electronic Data Capture (REDCap) system. The primary endpoint was a...
Significance In persons living with HIV-1 who start antiretroviral therapy, virus in the blood decreases rapidly to below detection limit. The decrease occurs two phases: a rapid initial first weeks, followed by second, slower phase occurring over next few months. These decay processes are important because infected cells that remain may become part of stable latent reservoir prevents cure. levels presumably reflects loss cells, but relationship between free and has been unclear. Here, we...
Combination antiretroviral therapy suppresses but does not eradicate human immunodeficiency virus type 1 (HIV-1) in infected persons, and low-level viremia can be detected despite years of suppressive therapy. Short-course (28-day) intensification standard combination is a useful approach to determine whether complete rounds HIV-1 replication rapidly cycling cells contribute persistent viremia. We investigated with the integrase inhibitor raltegravir decreases plasma RNA levels patients receiving
We sought to evaluate the impact of intense influenza media coverage during 2003-2004 season on vaccination status children 6 59 months age.Children age who presented a large, academic pediatric continuity clinic or affiliated acute care in summer 2004 were enrolled. A parental survey ascertained child and family members factors that influenced their status. For vaccinated health department, dates confirmed computerized medical chart state immunization registry.Of 256 enrolled children, 98...
Summary On the basis of an immunologic assay method developed with Boivin endotoxin E. coli O:113, behavior this and its antigenic component was studied in animals septic arthritis produced by parent organism. A single inoculation strain into knee rabbits established a severe that accompanied high spiking fever lasting 2 weeks. Somatic antigen found blood febrile absence bacteremia; observation indicated released living dead bacteria quantities exceeding those appeared to be bound locally...
Objectives: Telemedicine became the primary mode of delivering care during COVID-19 pandemic. We describe impact telemedicine on access to for people with HIV (PWH) by comparing proportion PWH engaged in prior and Design methods: conducted an observational analysis patients enrolled Johns Hopkins Clinical Cohort, a single-center cohort at urban subspecialty clinic affiliated academic center. Due pandemic, transitioned from in-person mostly visits. compared receiving two time periods. The...
Abstract Background During the 2022 mpox outbreak most patients were managed as outpatients, but some required hospitalization. Uncontrolled human immunodeficiency virus (HIV) has been identified a risk factor for severe mpox. Methods Patients with diagnosed or treated within Johns Hopkins Health System between 1 June and 15 December included. The primary outcome of interest was Demographic features, comorbid conditions, treatment, clinical outcomes determined. Results A total 353 tested...
Incidence trends for the 13 most frequent AIDS-defining opportunistic infections (OIs) among men who have sex with (MSM, n = 15,588) and injecting drug users (IDUs, 4475) were examined using data abstracted from medical records in > 90 hospitals clinics nine US cities during 1991–1996. Among MSM, OIs Mycobacterium avium complex (MAC) disease, Pneumocystis carinii pneumonia (PCP), cytomegalovirus (CMV) retinitis; decreasing (P ⩽ .05) occurred 11 (MAC PCP, CMV retinitis, Kaposi's sarcoma,...
Adults and adolescents diagnosed with AIDS from 1987 through 1992 residing in counties endemic (selected California, Arizona, Texas, New Mexico, Nevada, Utah) not for Coccidioides immitis were assessed to determine the frequency of risk factors disseminated coccidioidomycosis. Of 602 patients reported coccidioidomycosis, 323 (1.1% patients) resided C. immitis-endemic 279 (0.1% immitis-nonendemic 35 states. In multivariate analysis, coccidioidomycosis more likely be injecting drug users (odds...
We tested all samples from patients with ocular toxoplasmosis sent to the Palo Alto Medical Foundation Toxoplasma Reference Laboratory June 2004 through August 2010 for serologic evidence of recent gondii infection. Of 205 aged 10-96 years, 11.7% had Many people develop disease soon after T.
Abstract Background Food insecurity disproportionately affects people with HIV (PWH) and is associated increased transmission, interruptions in care, poor medication adherence. The intersection of depression, anxiety, substance use, food among PWH may further exacerbate adverse outcomes. This study assesses the association risk viral load (VL) non-suppression PWH, or at for comorbid mental health (MHD) use disorder (SUD), care. Methods care Johns Hopkins Bartlett Infectious Disease Clinic...
Abstract Background Due to shared modes of transmission, people with HIV (PWH) have disproportionately high rates hepatitis B virus (HBV) infection. Availability the HBV vaccine in US since 1982 and recommendations for universal catch-up vaccination infants children 1990s may be associated lower prevalence among PWH born after 1980. To study how availability impacted co-infection PWH, we compared active infection at entry into an cohort by birth year groups.Table 1.Baseline characteristics...
Abstract Background Mental health disorder (MHD) prevalence is high among people with HIV (PWH) and linked to poor outcomes, including non-suppression. Despite recommendations for routine mental screening in care settings, uptake remains low. The brief Patient Health Questionnaire-2 (PHQ-2) Generalized Anxiety Disorder-2 (GAD-2) are validated screeners depression anxiety symptoms potential integration into care. This study evaluates the accuracy of PHQ-2 GAD-2 detecting PWH co-occurring MHD...
<sec> <title>BACKGROUND</title> The HIV epidemic is a national focus within the United States (U.S.), Ending Epidemic (EHE) Initiative aiming to reduce new infections by 90% 2023 through scaling of prevention and treatment strategies. Data are crucial understanding HIV-related needs, barriers care, effectiveness interventions. While several publicly available datasets exist, few integrate multiple topic domains such as outcomes, social determinants health (SDOH), community-level factors....
Background: Ending the HIV Epidemic strategies include rapid ART Initiation (R-ART), pre-exposure prophylaxis (R-PrEP), and status neutral approaches (status neutral), but implementation across heterogeneous settings in United States is not well characterized. Setting: Ryan White (RW)–funded treatment clinics located select priority areas States. Methods: Clinics were sent a survey to assess experiences offering R-ART, R-PrEP, (collectively called “rapid START”). Primary outcomes START...
Background: Although rapid antiretroviral therapy (ART) and same-day pre-exposure prophylaxis models (henceforth “rapid START”) are feasible, acceptable, cost-effective in various contexts, significant barriers have hindered their broader implementation scalability the United States. Ryan White-funded clinics cornerstones for HIV services, yet strategies urgently needed to facilitate equitable START adoption across contexts. This study aimed identify common factors influencing inform...
Abstract: The Network for Implementation Science in HIV (NISH) was established to conduct multisite research study real-world implementation of evidence-based interventions across US contexts, and generate generalizable knowledge around strategies support the achievement Ending Epidemic goals. NISH sites represent diverse priority jurisdictions include participation multiple units within those (eg, clinics community-based organizations) bring together teams from backgrounds science service...
Antiretroviral therapy (ART) halts HIV-1 replication, reducing plasma virus levels to below the limit of detection, but it is not curative due a reservoir latently infected CD4+ T cells. In some people living with (PLWH), RNA becomes persistently detectable despite optimal ART. This nonsuppressible viremia (NSV) characterized by identical, non-evolving variants expressed from cell clones. The mechanisms driving persistent production specific population cells are poorly understood. We...
Abstract A pilot program was implemented to assess the feasibility of emergency department (ED) preexposure prophylaxis (PrEP) referral. Of 119 eligible patients approached and assessed, 39 (33%) expressed interest were referred peer navigators. these, 16 (41%) scheduled for appointments; four (10%) initiated PrEP, which demonstrated ED-based PrEP referral feasible.
Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants detectable virus-specific responses, a PWH was not on antiretroviral therapy and immunosuppressive therapy. These 2 robust polyfunctional CD4+ to peptides the 121L vaccinia (VACV) protein. T-cells 4 of 5 HLA-A2-positive targeted at least 1 previously described HLA-A2-restricted VACV epitope, an epitope participants....
Point-of-service (POS) HIV testing in sexually transmitted infection (STI) clinics is one public health strategy to increase knowledge of serostatus and facilitate entry into care. Variation has been reported clients' views test reliability rates acceptance. Our objective was characterize STI clinic patients' choice POS versus conventional (enzyme-linked immunosorbant assay [ELISA] followed by Western blot, with results 1 week) Baltimore, Maryland (a high-prevalence city) when both were...