Three-dimensional Pd@Pt core−shell nanostructures with controllable shape and composition were synthesized by using a one-step microwave heating method. The the morphology, structure, being easily controlled through adjusting molar ratio between Pt Pd precursor characterized transmission electronic microscopy (TEM), scanning (SEM), X-ray powder diffraction (XRD), energy-dispersive (EDX) techniques. In addition, electrocatalytic characteristics of these prepared electrocatalysts different...

Recent studies have found that viral myocarditis (VMC) associated with coxsackievirus B3 (CVB3) causes autophagy activation after infection, but the specific mechanism is not clear. The present study demonstrated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway participates in CVB3‑induced autophagy. We light chain 3 (LC3)‑Ⅱ/LC3‑I ratio was increased and p62 p‑mTOR were altered at different times during CVB3 infection. To...

The aim of the present study was to investigate role angiotensin-converting enzyme (ACE)2-angiotensin‑(Ang)-(1-7)-Mas axis in pathogenesis pancreatitis and association between this p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor (NF-κB) signaling pathway pancreatic acinar cells. Mouse cancer (MPC-83) cells were stimulated with 10 nM caerulein (CAE) create an vitro model acute pancreatitis, collected for analysis at 2, 6, 12, 24 48 h post stimulation. In addition, pretreated...

Abstract Coxsackievirus B3 (CVB3) is an important human pathogen linked to cardiac arrhythmias and acute heart failure. CVB3 infection has been reported induce the formation of autophagosomes that support viral replication in host cells. Interestingly, our study shows accumulation during caused by a blockage autophagosome–lysosome fusion rather than induction autophagosome biogenesis. Moreover, decreases transcription translation syntaxin 17 (STX17), SNARE (soluble N...

Although firms in diverse industries increasingly adopt private regulation of labor standards for workers their global supply chains, growing scholarly evidence suggests that this approach has not generated sustainable improvements working conditions those workers. The authors draw on recent developments institutional theory regarding the development opaque fields cause decoupling between practices and outcomes to develop a new explanation lack improvement chains. Using qualitative...

Abstract Based on extensive field research in C hina during 2005–2010, this article aims to explore the determinants of unionization hinese context. We find that managerial strategies toward union organizing and functioning have been critical determining outcomes enterprises. While various environment pressures may impose constraints these strategies, industrial relations ideologies are central shaping when barely exist or bearable by management. Our study makes first effort exploring...

Spermatogenesis depends on precise epigenetic and genetic regulation of spermatogonial stem cells (SSCs). However, it remains largely unknown about the roles mechanisms small noncoding RNA in regulating self-renewal apoptosis human SSCs. Notably, we have found that Homo sapiens-microRNA (hsa-miR)-1908-3p is expressed at a higher level spermatogonia than pachytene spermatocytes. MiR-1908-3p stimulated cell proliferation DNA synthesis SSC line. Allophycocyanin (APC) Annexin V propidium iodide...

Scholars and practitioners have advocated for freedom of association collective bargaining (FOA/CB) rights as a key mechanism to improve labor compliance in global supply chains. Drawing on longitudinal data set comprising 6,500 Better Work factory assessments across seven countries from 2015 2021, the authors compare violations various FOA/CB elements provide general picture progress problems supplier workplaces. They argue that suppliers are likely selectively comply with afford them some...

A new method developed for the reliable determination of extracellular and intracellular H(2)O(2) is very useful gaining a full understanding role that plays in pathology physiology, relationship between environmental stresses lipid peroxidation. This work validated an electrochemical approach released from RAW 264.7 murine macrophage cells. based on electrocatalytic reduction at biosensor HRP-HAP/GC, which was fabricated by depositing horseradish peroxidase-hydroxyapatite (HRP-HAP)...

Listeriosis is a rare but severe foodborne infectious disease. Perinatal listeriosis often associated with septicemia, central nervous system (CNS) infection, and serious adverse pregnancy outcomes (miscarriage neonate death). Here we report the characteristics of perinatal cases treated over 6 years at Beijing Obstetrics Gynecology Hospital (BOGH), largest maternity hospital in China.We retrospectively reviewed records laboratory-confirmed, pregnancy-associated from January 1, 2013 to...

This article outlines a research agenda for Freedom of Association and Collective Bargaining, two fundamental labor rights essential to the achievement “Decent Work” workers in global supply chains. The authors argue that SCM scholars are uniquely positioned address how workers’ freedom association collective bargaining chains could be improved. stems, part, from fact researchers industry practitioners share common “logic efficiency” analysis suggest three broad areas on bargaining, with...

Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of human SSCs remain elusive. In this study, we revealed that KLF2 decreased the proliferation, DNA synthesis, colonization as well increased apoptosis these cells. We identified demonstrated GJA1 was a target gene in SSCs. Notably, overexpression rescued reduction proliferation caused by silencing enhancement Abnormalities higher level and/or

Sertoli cell-only syndrome (SCOS) is one of the most severe non-obstructive azoospermia (NOA) types, since only cells with not any male germ exist seminiferous tubules. As such, it particular significance to elucidate molecular mechanisms underlying SCOS for improving diagnosis and treatment strategies this disease. Due difficulties in obtaining sufficient human testicular tissues limited availability cells, traditional proteomics inadequate comparing differences large scale protein...

Abstract Background and Objectives Osteoarthritis (OA) is a widespread degenerative joint disease characterized by articular cartilage degradation the leading cause of physical disability. Noncoding RNAs, especially long noncoding RNAs (lncRNAs) microRNAs, are involved in chondrocyte extracellular matrix (ECM) patients with OA. The present study was aimed to investigate effects lncRNA miR‐22 on ECM underlying mechanisms. Methods To simulate conditions found OA, primary cultured chondrocytes...

Abstract Studies on gene regulation and signaling transduction pathways of human spermatogonial stem cells (SSCs) are the utmost significance for unveiling molecular mechanisms underlying spermatogenesis therapy male infertility. We have demonstrated, first time, that RNF144B stimulated cell proliferation inhibited apoptosis SSCs. The target was identified as FCER2 by RNA sequencing. revealed interacted with immunoprecipitation. Consistently, overexpression reversed phenotype SSCs caused...

Kawasaki disease (KD) is a childhood systemic vasculitis that exhibits specific preference for the coronary arteries. The aetiology remains unknown and there are no especially diagnostic tests. microRNAs (miRNAs) 18 to 23 nucleotides non-coding RNAs negative regulator of gene expression play crucial role in regulatory network genome. Recently, circulating miRNAs have been found presentation human plasma displayed some characteristics ideal biomarker. However, few researches explored...

In contrast to various structural accounts of collective inaction or short-lived contention Chinese workers, the authors take an agency-centered approach explain how few sustained labor protests during closure bargaining develop against all odds. They suggest that workers’ capacity resolve action problems is essential understanding why a contending workers are able sustain whereas many others fail do so. argue workplace representatives and external activists crucial for helping prevent...

Human papillomavirus (HPV) infections were the main cause of anogenital cancers and warts. HPV 6/11/16/18 vaccines provide protection against high-risk types responsible for 70% cervical 90% genital This randomized, blinded, non-inferiority phase III trial was to determine whether immunogenicity tolerability would be non-inferior among women after receiving two novel 4- 9-valent (4vHPV, 6/11/16/18; 9vHPV, 6/11/16/18/31/33/45/52/58) compared with those Gardasil 4 (4-valent). 1680 females...

Extensive apoptosis of pancreatic acinar cells frequently occurs in acute pancreatitis (AP), and has been identified to be closely associated with the decrease parenchymal damage. The present study aimed investigate possible effect angiotensin (Ang)‑(1‑7) on caerulein (CAE)‑induced cell apoptosis. Mouse cancer (MPC‑83) were divided into 4 groups: Control group; CAE + Ang‑(1‑7) antagonist (A779) group. control group consisted normal MPC‑83 without special treatment. was stimulated 10 nmol/l...