A5006613958- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Head and Neck Surgical Oncology
- Fatty Acid Research and Health
- Birth, Development, and Health
- Neuroethics, Human Enhancement, Biomedical Innovations
- Pituitary Gland Disorders and Treatments
- Spinal Dysraphism and Malformations
- Ethics and Legal Issues in Pediatric Healthcare
- Meningioma and schwannoma management
- Neuroscience of respiration and sleep
- Pregnancy and preeclampsia studies
- Pluripotent Stem Cells Research
- Fetal and Pediatric Neurological Disorders
- Prenatal Substance Exposure Effects
- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Preterm Birth and Chorioamnionitis
Children's Hospital of Philadelphia
2025
University of Pennsylvania
2025
Johns Hopkins University
2022-2023
Adult and Pediatric Dermatology
2022-2023
Johns Hopkins Medicine
2022-2023
Tumours of the anterior skull base present unique surgical challenges due to critical neurovascular proximity and developing cranial anatomy. While open transcranial approaches (TCAs) have traditionally been used for these tumors, endoscopic endonasal approach (EEA) is preferred reduced morbidity higher gross total resection (GTR) rates (1). Studies report excellent GTR reconstructive outcomes with EEA in under-18 paediatric population, complications including cerebrospinal fluid (CSF) leak,...
The natural history of cephaloceles is not well understood. goal this study was to better understand the fetal from prenatal diagnosis postnatal period. Between January 2013 and April 2023, all patients evaluated with a cephalocele at Center for Fetal Diagnosis Treatment were identified. All underwent MRI. Demographic imaging covariates obtained electronic medical record. Volumetric analyses performed determine percentage neural tissue within cephalocele. Progressive herniation defined as an...
Opioid use during pregnancy continues to rise at alarming rates with a parallel trend in the number of infants and children exposed opioid medications each year. Prenatal exposure (POE) occurs critical timepoint neurodevelopment disrupting intricate pathways essential for neural-immune maturation potential devastating long-term consequences. Understanding mechanisms underlying injury associated POE is address outcomes identify diagnostic therapeutic biomarkers this vulnerable patient...
Cerebral palsy (CP) is the most common cause of physical disability for children worldwide. Many infants and toddlers are not diagnosed with CP until they fail to achieve obvious motor milestones. Currently, there no effective pharmacologic interventions available substantially improve their trajectory neurodevelopment. Because from preterm birth also exhibit a sustained immune system hyper-reactivity, we hypothesized that neuro-immunomodulation regimen repurposed endogenous neurorestorative...
<ns4:p>Brain organoids are self-organizing, three-dimensional tissues derived from pluripotent stem cells that recapitulate many aspects of the cellular diversity and architectural features developing brain. Recently, there has been growing interest in using human brain organoid transplantation animal models as a means addressing limitations <ns4:italic>in vitro</ns4:italic> culture, such lack vascularization, to explore potential for neural repair. While substantial debate on ethical...
Introduction: Novel therapeutics are emerging to mitigate damage from perinatal brain injury (PBI). Few newborns with PBI suffer a singular etiology. Most experience cumulative insults prenatal inflammation, genetic and epigenetic vulnerability, toxins (opioids, other drug exposures, environmental exposure), hypoxia-ischemia, postnatal stressors such as sepsis seizures. Accordingly, tailoring of therapeutic regimens endogenous repair or neuro-immunomodulatory agents for individuals requires...