A5084814162- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Cerebral Palsy and Movement Disorders
- Fetal and Pediatric Neurological Disorders
- Prenatal Substance Exposure Effects
- Genetics and Neurodevelopmental Disorders
- Preterm Birth and Chorioamnionitis
- Cardiac Arrest and Resuscitation
- Tuberous Sclerosis Complex Research
- Neuroscience of respiration and sleep
- Digestive system and related health
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Hallucinations in medical conditions
- Assistive Technology in Communication and Mobility
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Child Nutrition and Water Access
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical and Biological Ozone Research
- Pharmacology and Obesity Treatment
- Polyomavirus and related diseases
Kennedy Krieger Institute
2015-2025
Johns Hopkins Medicine
2011-2025
Johns Hopkins University
2011-2025
Karolinska Institutet
2024
Nationwide Children's Hospital
2024
Centre Hospitalier Universitaire Sainte-Justine
2024
Université de Montréal
2024
Behavioral Pharma (United States)
2022-2023
University of New Mexico
2020
Early diagnosis of cerebral palsy (CP) is critical in obtaining evidence-based interventions when plasticity greatest. In 2017, international guidelines for early detection CP were published on the basis a systematic review evidence. Our study aim was to reduce age at throughout network 5 diverse US high-risk infant follow-up programs through consistent implementation these guidelines.
Neurodevelopmental disabilities persist in survivors of neonatal hypoxic-ischemic encephalopathy (HIE) despite treatment with therapeutic hypothermia. Cerebrovascular autoregulation, the mechanism that maintains cerebral perfusion during changes blood pressure, may influence outcomes. Our objective was to describe relationship between acute autoregulatory vasoreactivity and neurodevelopmental outcomes at 2 years age. In a pilot study 28 neonates HIE, we measured hemoglobin volume index (HVx)...
Background/Objectives: The Hammersmith Infant Neurological Examination (HINE) is a standardized neurologic exam for infants between 2 and 24 months. Scores can be compared to optimality cutoffs as one component support an early diagnosis of cerebral palsy (CP). Some prognosis also possible diagnosed with CP. We aimed understand the longitudinal trajectories HINE scores in who were ultimately Methods: Clinical records reviewed children CP two high-risk infant follow-up clinics from at least...
Early studies following perinatal hypoxic-ischemic encephalopathy (HIE) suggested expressive language deficits and academic difficulties, but there is only limited detailed study of development in this population since the widespread adoption therapeutic hypothermia (TH). Expressive receptive testing was performed as part a larger battery with 45 children mean age 26 months HIE treated TH. Overall cohort outcomes well effects gender, estimated household income, initial pH base excess,...
Brain injury remains a serious complication of prematurity. Almost half infants with severe intraventricular hemorrhage (IVH) develop posthemorrhagic ventricular dilatation (PHVD) and 20% need surgery for hydrocephalus (PHH). This population is associated an increased risk later neurodevelopmental disability, but there uncertainty about which radiological examination features predict disability. In this study the authors sought to devise describe novel combination neurobehavioral imaging...
Objective: To determine the changes due to therapeutic hypothermia (TH) exposure in strength of association between traditional clinical and biochemical indicators severity neonatal hypoxic-ischemic encephalopathy (HIE) serum biomarkers. We hypothesized that culmination TH relationships HIE Methods: This was a single-center observational cohort study 178 neonates with treated followed biomarkers: (i) brain-derived neurotrophic factor (BDNF) vascular endothelial growth (VEGF) (neurotrophins);...
Opioid use during pregnancy continues to rise at alarming rates with a parallel trend in the number of infants and children exposed opioid medications each year. Prenatal exposure (POE) occurs critical timepoint neurodevelopment disrupting intricate pathways essential for neural-immune maturation potential devastating long-term consequences. Understanding mechanisms underlying injury associated POE is address outcomes identify diagnostic therapeutic biomarkers this vulnerable patient...
Aim: Hypoxic-ischemic encephalopathy is associated with damage to deep gray matter; however, white matter involvement has become recognized. This study explored differences between patients and clinical controls on diffusion tensor imaging, relationships imaging neurodevelopmental outcomes. Method: Diffusion was obtained for 31 neonates after hypoxic-ischemic treated therapeutic hypothermia 10 controls. A subgroup of (n = 14) had outcomes correlated scalars. Results: Group in scalars were...
Cerebral palsy (CP) is the most common cause of physical disability for children worldwide. Many infants and toddlers are not diagnosed with CP until they fail to achieve obvious motor milestones. Currently, there no effective pharmacologic interventions available substantially improve their trajectory neurodevelopment. Because from preterm birth also exhibit a sustained immune system hyper-reactivity, we hypothesized that neuro-immunomodulation regimen repurposed endogenous neurorestorative...
Abstract Minimizing central nervous system (CNS) injury from preterm birth depends upon understanding the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. Signaling by chemokine (C‐X‐C motif) ligand 1 (CXCL1) through its cognate receptor, CXCR2 [(C‐X‐C receptor 2] is for neurodevelopment. Increased signaling, however, implicated in a variety of uterine neuropathologies, their role associated with perinatal brain poorly defined. To evaluate long‐term...
Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic and somatosensory, motor, cognitive, etiologic, environmental factors This cross-sectional study enrolled 17 adult participants palsy (mean age 31 years; 8 female; Gross Motor Functional Classification Status levels I-V) able self-report 10 neurotypical volunteers 34 9 female). Participants reported characteristics, demographics, affective factors. Physical examination included...