A5019999058- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Vitamin D Research Studies
- Biomarkers in Disease Mechanisms
- Diet and metabolism studies
- Therapeutic Uses of Natural Elements
- Adipokines, Inflammation, and Metabolic Diseases
- Salivary Gland Disorders and Functions
- Ferroptosis and cancer prognosis
- Retinal Development and Disorders
- Pain Mechanisms and Treatments
- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
- Neuroscience and Neural Engineering
- Systemic Lupus Erythematosus Research
- Iron Metabolism and Disorders
- Photoreceptor and optogenetics research
- Selenium in Biological Systems
- Herpesvirus Infections and Treatments
- Diet, Metabolism, and Disease
- Aluminum toxicity and tolerance in plants and animals
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Healthcare and Venom Research
Taipei Medical University
2019-2025
Wan Fang Hospital
2020-2025
Taipei Medical University-Shuang Ho Hospital
2019
DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) one of the global markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought investigate correlation between 5mdC developmental delay (DD) among preschoolers. Additionally, we assessed whether modified impacts blood total urinary arsenic levels on DD. We analyzed concentrations 5mdC, cadmium lead, 174 children DD 88 healthy...
Myeloperoxidase (MPO) is an oxidative stress biomarker, with elevated MPO levels linked to chronic kidney disease (CKD) progression. Metal exposure a risk factor for CKD, and also correlated expression, specific genotypes expression. Therefore, we examined whether plasma or polymorphisms were explored these factors modified associations between CKD metal concentrations. Accordingly, recruited 395 age- sex-matched controls 215 patients (persistent estimated glomerular filtration rate (eGFR) <...
In renal cell carcinoma (RCC), tissue inhibitor of metalloproteinase (TIMP) 3 expression is lost, suggesting that the TIMP3 gene may function as a tumor suppressor gene. Cadmium (Cd) and arsenic (As) exposure affect TIMP3. Here we investigate association clear RCC with polymorphisms, explore whether polymorphisms modify relationship between blood Cd or total urinary As levels respectively. We recruited 281 patients 689 sex- age-matched controls. The was diagnosed by pathological evaluation...
Adiponectin is an adipokine multipeptide hormone with insulin-sensitizing; anti-atherosclerotic; and anti-inflammatory properties. Chronic kidney disease (CKD) may be associated low adiponectin. The adiponectin gene ADIPOQ thought to the only major responsible for plasma levels; which are diabetes diabetic nephropathy. purpose of this study was investigate association between polymorphism CKD. In addition; combined effects levels total urinary arsenic blood cadmium on CKD were also explored....
Glycated hemoglobin (HbA1c) levels are an important index for the diagnosis and long-term control of diabetes. This study is first to use a direct label-free photoelectric biosensor determine HbA1c using bacteriorhodopsin-embedded purple membranes (PM) as transducer. A biotinylated PM (b-PM) coated electrode that layered with protein A-oriented antibodies against (Hb) readily captures non-glycated Hb (HbA0) generates less photocurrent. The spectra bacteriorhodopsin overlap so photocurrent...
The sex and age differences in the relationship between vitamin D lipid levels remain unclear. This retrospective study investigated correlations serum 25-hydroxyvitamin various biomarkers, along with these associations, among 573 men 436 women during physical check-ups. mean of population was 51.4 years, 66% people had 25(OH)D below 30 ng/mL. People aged over 65 years higher than those younger lower men. Younger (odds ratio (OR) per year = 1.044, 95% CI, 1.029−1.059, p < 0.0001), female (OR...
Overnutrition with a high-fat or high-sugar diet is widely considered to be the risk factor for various metabolic, chronic, malignant diseases that are accompanied by alterations in gut microbiota, metabolites, and downstream pathways. In this study, we investigated supplementation soybean fermentation broth containing saponin (SFBS, also called SAPOZYME) male C57BL/6 mice fed high-fat-fructose normal chaw. addition lessening of weight gain, influence SFBS on reducing hyperlipidemia...
Sjogren's syndrome (SS) is a systemic autoimmune disease featured with dry mouth and eyes. Several autoantibodies, including anti-SSA, anti-SSB, antinuclear antibodies can be detected in patients SS. Oxidation-specific epitopes (OSEs) formed from malondialdehyde (MDA)-modified protein adducts trigger chronic inflammation. In this study, our purposes were used serum levels of anti-MDA-modified peptide autoantibodies to evaluate predictive performance by machine learning algorithms primary...