A5015979276- Metal-Organic Frameworks: Synthesis and Applications
- Nanoplatforms for cancer theranostics
- X-ray Diffraction in Crystallography
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Mesenchymal stem cell research
- Crystallization and Solubility Studies
- Advanced Nanomaterials in Catalysis
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Biosimilars and Bioanalytical Methods
- Iron oxide chemistry and applications
- Cytomegalovirus and herpesvirus research
- Advanced Malware Detection Techniques
- Erythrocyte Function and Pathophysiology
- Luminescence and Fluorescent Materials
- Machine Learning in Materials Science
Sandia National Laboratories
2018-2024
University of New Mexico
2007-2018
Center for Devices and Radiological Health
2014-2015
United States Food and Drug Administration
2015
Office of Science
2015
New Mexico Cancer Center
2010-2013
University of New Mexico Hospital
2009
Chemetall (Germany)
2009
Tuskegee University
1997
Auburn School District
1997
Abstract The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled, mesoporous silica nanoparticles (MSNs), we apply integrated SPECT/CT imaging and mathematical modeling approach understand the combined effects MSN size, surface chemistry routes administration on biodistribution clearance kinetics healthy rats. We show that increased particle size from ~32-...
Many nanocarrier cancer therapeutics currently under development, as well those used in the clinical setting, rely upon enhanced permeability and retention (EPR) effect to passively accumulate tumor microenvironment kill cells. In leukemia, where leukemogenic stem cells their progeny circulate within peripheral blood or bone marrow, EPR may not be operative. Thus, for leukemia therapeutics, it is essential target bind individual circulating Here, we investigate mesoporous silica nanoparticle...
The focus of this research was to develop a better understanding the pertinent physico-chemical properties silver nanoparticles (AgNPs) that affect genotoxicity, specifically how cellular uptake influences genotoxic cell response. genotoxicity AgNPs assessed for three potential mechanisms: mutagenicity, clastogenicity and DNA strand-break-based damage. Mutagenicity (reverse mutation assay) in five bacterial strains Salmonella typhimurium Echerichia coli, including TA102 is sensitive...
Herein, we describe a novel multifunctional metal-organic framework (MOF) materials platform that displays both porosity and tunable emission properties as function of the metal identity (Eu, Nd, tuned compositions Nd/Yb). Their collectively spans deep red to near-infrared (NIR) spectral region (∼614-1350 nm), which is highly relevant for in vivo bioimaging. These new meet important prerequisites biological processes: they are minimally toxic living cells retain structural integrity water...
Long-term antimicrobial therapies are necessary to treat infections caused by virulent intracellular pathogens, including biothreat agents. Current treatment plans include injectable therapeutics given multiple times daily over a period for up 8 weeks. Here, we present metal–organic framework (MOF), zeolitic imidazolate framework-8 (ZIF-8), as robust platform support the sustained release of ceftazidime, an important agent many critical bacterial infections. Detailed material...
Abstract Introduction Breast cancer detection using mammography has improved clinical outcomes for many women, because can detect very small (5 mm) tumors early in the course of disease. However, fails to 10 - 25% tumors, and results do not distinguish benign malignant tumors. Reducing false positive rate, even by a modest 10%, while improving sensitivity, will lead screening, is desirable attainable goal. The emerging application magnetic relaxometry, particular superconducting quantum...
The design and synthesis of artificial materials that mimic the structures, mechanical properties, ultimately functionalities biological cells remains a current holy grail science. Here, based on silica cell bioreplication approach, we report construction synthetic rebuilt red blood (RRBCs) fully broad properties native RBCs: size, biconcave shape, deformability, oxygen-carrying capacity, long circulation time. Four successive nanoscale processing steps (RBC bioreplication, layer-by-layer...
Abstract Optical tags provide a way to quickly and unambiguously identify valuable assets. Current tag fluorophore options lack the tunability allow combined methods of encoding in single material. Herein we report design strategy encode multilayer complexity family heterometallic rare‐earth metal–organic frameworks based on highly connected nonanuclear clusters. To impart both intricacy security, synergistic approach was implemented resulting overt (visible) covert (near‐infrared, NIR)...
Abstract Lifetime-encoded materials are particularly attractive as optical tags, however examples rare and hindered in practical application by complex interrogation methods. Here, we demonstrate a design strategy towards multiplexed, lifetime-encoded tags via engineering intermetallic energy transfer family of heterometallic rare-earth metal-organic frameworks (MOFs). The MOFs derived from combination high-energy donor (Eu), low-energy acceptor (Yb) an optically inactive ion (Gd) with the...
Metal–organic frameworks (MOFs) are a class of porous, crystalline materials that have been systematically developed for broad range applications. Incorporation two or more metals into single phase to generate heterometallic MOFs has shown lead synergistic effects, in which the whole is oftentimes greater than sum its parts. Because geometric proximity typically required function cooperatively, deciphering and controlling metal distributions crucial establish structure–function...
Both magnetic relaxometry and resonance imaging (MRI) can be used to detect locate targeted nanoparticles, noninvasively without ionizing radiation. Magnetic offers advantages in terms of its specificity (only nanoparticles are detected) the linear dependence signal on number present. In this study, detection single‐core iron oxide by superconducting quantum interference device (SQUID)‐detected standard 4.7 T MRI compared. The were conjugated a Her2 monoclonal antibody Her2‐expressing...
Abstract Previous studies have shown that a field of genetically altered but histologically normal tissue extends 1 cm or more from the margins human breast tumors. The extent, composition and biological significance this are only partially understood, molecular alterations in affected cells could provide mechanisms for limitless replicative capacity, genomic instability microenvironment supports tumor initiation progression. We demonstrate by microarray, qRT‐PCR immunohistochemistry...
The high density of the extracellular matrix in solid tumors is an important obstacle to nanocarriers for reaching deep tumor regions and has severely limited efficacy administrated nanotherapeutics. use proteolytic enzymes prior nanoparticle administration or directly attached nanocarrier surface been proposed enhance their penetration, but low vivo stability these macromolecules compromises strongly limits application. Herein, we have designed a multifunctional able transport cytotoxic...
We report on the availability and chemical utility of primary amines within metal–organic frameworks (MOFs) for cell targeting. Primary amine groups represent one most versatile moieties conjugation to biologically relevant molecules, including antibodies enzymes. Specifically, we used two different conjugations schemes, utilizing amino functionality organic linker: first, carbodiimide chemistry was link available carboxyl protein neutravidin; second, sulfhydryl cross-linking via Traut's...
Optical anticounterfeiting tags utilize the photoluminescent properties of materials to encode unique patterns, enabling identification and validation important items assets. These must combine optical complexity with ease production authentication both prevent counterfeiting remain practical for widespread use. Metal-organic frameworks (MOFs) based on polynuclear, rare earth clusters are ideal platforms this purpose, combining fine control over structure composition, tunable, complex energy...
Abstract Emerging and re-emerging viral pathogens present a unique challenge for anti-viral therapeutic development. Anti-viral approaches with high flexibility rapid production times are essential combating these high-pandemic risk viruses. CRISPR-Cas technologies have been extensively repurposed to treat variety of diseases, recent work expanding into potential applications against infections. However, delivery still presents major technologies. Lipid-coated mesoporous silica nanoparticles...
Optimizing the sensitivity of SQUID (superconducting quantum interference device) relaxometry for detecting cell-targeted magnetic nanoparticles in vivo diagnostics requires with a narrow particle size distribution to ensure that Néel relaxation times fall within measurement timescale (50 ms–2 s, this work). To determine optimum size, single-core magnetite (with nominal average diameters 20, 25, 30 and 35 nm) were characterized by relaxometry, transmission electron microscopy, susceptometry,...