A5039832070- Ocular Oncology and Treatments
- Circadian rhythm and melatonin
- Cutaneous Melanoma Detection and Management
- Monoclonal and Polyclonal Antibodies Research
- Nonmelanoma Skin Cancer Studies
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Brain Metastases and Treatment
- Glycosylation and Glycoproteins Research
- Ocular Disorders and Treatments
- COVID-19 and Mental Health
- Hallucinations in medical conditions
- Bacteriophages and microbial interactions
- Corneal Surgery and Treatments
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Body Image and Dysmorphia Studies
- Statistical Methods in Clinical Trials
- BRCA gene mutations in cancer
- Family Support in Illness
- Ocular Infections and Treatments
- Digital Mental Health Interventions
- Protein purification and stability
- Childhood Cancer Survivors' Quality of Life
University of Liverpool
2013-2024
Aintree University Hospitals NHS Foundation Trust
2022-2024
Royal Liverpool University Hospital
2022
University of Plymouth
2022
Royal Liverpool and Broadgreen University Hospital NHS Trust
2015-2020
University College London
1994-2002
The Royal Free Hospital
1994-2001
Roland Hill (United Kingdom)
1994-1996
Antibody-directed enzyme prodrug therapy is a targeted in which activated selectively at the tumour site by an enzyme, has been to antibody (antibody-enzyme conjugate). Previous clinical trials have shown evidence of response, however, drug had long half-life, resulted dose-limiting myelosuppression. Also, targeting system, although giving high blood ratios antibody-enzyme conjugate (10 000:1) required administration clearing addition conjugate. The purpose this current study therefore was...
Cancer survivors experience uncertainty about the future, which can be distressing. A prognostication tool is available for uveal melanoma survivors, provide accurate estimates of life expectancy - a key source uncertainty. Accurate prognostic information has not previously been healthy cancer survivors. The aims this study were to identify how patients and it affects their uncertainty.Semi-structured interviews conducted with 25 6-60 months after treatment (approximately 8-62 receiving...
Antibody engineering has made it possible to design antibodies with optimal characteristics for delivery of radionuclides tumour imaging and therapy. A humanised divalent-Fab' cross-linked a bis-maleimide linker referred as maleimide was produced result this process. It is divalent antibody no Fc, which can be in bacteria enhanced stability compared F(ab')(2). Here we describe clinical study patients colorectal cancer using generated from the anti-carcinoembryonic antigen A5B7 radiolabelled...
Abstract Objective Cancer survivors commonly experience long‐term anxiety and depression. Anxiety depression might result from problems emerging during survivorship rather than illness treatment. This study tested three potential causal paths: (a) concerns about physical symptoms functional fear of cancer recurrence (FCR) arising directly cause depression, (b) an indirect path whereby FCR mediates effects on (c) a reciprocal FCR, which exacerbate later Methods Sample 453 uveal melanoma who...
Patients with choroidal melanoma can develop psychological morbidity because of visual disability, pain, facial deformity, and fears metastatic disease. The aim this study was to report on the prevalence symptoms, moods, well-being after radiotherapy or enucleation for how these outcomes changed over time.Participants were mailed questionnaires approximately 6 months following treatment, then annually every anniversary their treatment.Soon enucleation, patients experienced difficulties loss...
Abstract Objective We examined the role of posttreatment symptoms and functional problems worry about recurrent disease (WREC) in predicting probable anxiety depression cases 24 months after diagnosis survivors posterior uveal melanoma. whether WREC mediates links between symptoms, problems, cases. Methods Prospective cohort study 261 treated melanoma 6, 12, diagnosis. Hierarchical logistic regression analyses identified by Hospital Anxiety Depression Scale cutoff scores. Symptoms, 6‐month...
We appraise the role of screening for distress as part health psychology assessment patients newly diagnosed with cancer. reviewed records consecutive who accepted a psychologist's over 4 years, examining convergence and divergence result (whether reached threshold 'cases') clinical judgment need intervention. Of 261 patients, 88 (33.7%) were 'cases'. these, psychological intervention was identified in 70 (79.5%). 173 (66.3%) 'non-cases', 59 (34.1%). Examination cases where diverged from...
Prognostication in cancer is growing importance as increasingly accurate tools are developed. Prognostic accuracy intensifies ethical concerns that a poor prognosis could be psychologically harmful to survivors. Uveal melanoma (UM) prognostication allows survivors reliably told life expectancy either normal (good prognosis) or severely curtailed because of metastatic disease (poor prognosis). Treatment cannot change expectancy. To identify whether associated with psychological harm, we...
Severe or persistent distress is associated with poorer quality of life in cancer survivors. Distress follows distinct trajectories within different population subgroups. Identifying characteristics and causes can assist intervention development targeting. In a 7-year study uveal melanoma survivors, we aimed to characterize anxiety, depression, fear recurrence (FCR) trajectories, identify whether concerns about symptoms functional problems over the first 3 years survivorship predict...
Abstract Background Phantom eye symptoms (PES), particularly phantom visual sensations (PVS) and pain (PEP), are common in enucleated patients can lead to psychological distress. Current cross-sectional studies cannot examine the temporal course of symptoms, nor they identify dynamic risk factors or consequences PES. Methods Cohort study 105 uveal melanoma returning self-report questionnaires, within 4 weeks diagnosis 6-, 12- 24-months post-treatment. Questionnaires measuring PVS PEP week...
Empathy has been identified as an important communication skill that can improve psychological outcomes for patients with cancer and palliative care patients; such there is a need nurses to be empathic. The majority of research carried out concerned the definition measurement empathy. Exploration into concept empathy shown examine nature it identify exactly where succeeds fails. questions how nurtured sustained under what conditions flourishes diminishes addressed. This study aimed...
A number of patient-reported outcomes (PROs) predict increased mortality after primary cancer treatment. Studies, though, are sometimes affected by methodological limitations. They often use control variables that poorly life expectancy, examine only one or two PROs thus not controlling potential confounding unmeasured PROs, and observe at a single point in time. To all-cause mortality, this study used affording good estimates conducted multivariate analyses multiple to identify independent...
Abstract Background Technological advances have led to cancer prognostication that is increasingly accurate but often unalterable. However, a reliable prognosis of limited life expectancy can cause psychological distress. People should carefully consider offers prognostication, little known about how and why they decide on prognostication. Using uveal melanoma (UM) patients, we aimed identify (i) do people with UM accept (ii) alignment divergence their decision‐making from conceptualizations...
Phase I/II trials of new cancer therapies are designed to determine safety, efficacy and the optimal regimen for treatment. In order uphold principle that ‘the interests subject must prevail over science society’ as laid down in Declaration Helsinki effects these on quality life be determined. Antibody-targeted a form therapy selectively deliver cytotoxic agents cells. Twenty-four patients with advanced colorectal were enrolled into three different treatment modalities based this theme....
Abstract Objective Fear of cancer recurrence (FCR) may develop into elevated anxiety or depression symptoms, but few risk factors for this development are known. estimation is possible in some cancers. Using theories communication and phobias, we examined whether the proportionality FCR to known objective influences symptoms. Method Uveal melanoma (UM) patients can opt reliable prognostic testing. Patients experience either a ‘good’ ‘poor’ outcome, whereby 10‐year mortality due metastatic...
To explore the experiences of therapists who delivered remote psychological therapy during COVID-19 pandemic.This was a qualitative, phenomenological study. Interpretative Phenomenological Analysis elicited themes from semi-structured interviews.A purposive sample eight recruited breast cancer services in United Kingdom.Analysis identified three superordinate themes. Participants spoke about how their experience working changed over time an initial crisis response to new status quo. They...