A5035304300- Treatment of Major Depression
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Pharmacology and Obesity Treatment
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- Complement system in diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Advancements in Transdermal Drug Delivery
- Rabbits: Nutrition, Reproduction, Health
- Immunotherapy and Immune Responses
- Urinary Tract Infections Management
- Clinical practice guidelines implementation
- Marine Biology and Environmental Chemistry
- Computational Drug Discovery Methods
- Venous Thromboembolism Diagnosis and Management
- Pelvic floor disorders treatments
- Animal Nutrition and Physiology
- Phosphodiesterase function and regulation
- Veterinary Pharmacology and Anesthesia
- Renal Diseases and Glomerulopathies
- Trypanosoma species research and implications
Tohoku University Hospital
2017
Josai University
2016
Astellas Pharma (Japan)
2012-2013
Astellas Pharma (China)
2012
Abstract Retinoid X receptor (RXR) is a nuclear that plays important and multiple roles in mammalian development homeostasis. We previously reported that, human choriocarcinoma cells, tributyltin chloride triphenyltin hydroxide, which are typical environmental contaminants cause masculinization female mollusks, potent stimulators of chorionic gonadotropin production aromatase activity, play key endocrine functions maintaining pregnancy fetal development. However, the molecular mechanism...
TP0473292 (the active ingredient of TS-161) is a prodrug novel metabotropic glutamate (mGlu) 2/3 receptor antagonist being developed for the treatment patients with depression. This study evaluated safety, tolerability, and pharmacokinetics orally administered TS-161 in healthy subjects.This was first-in-human, phase 1, randomized, double-blind, placebo-controlled, single-ascending dose (15-400 mg 10-day multiple-ascending (50-150 subjects, conducted from June 2019 through February 2020....
An adequate immune response to percutaneous vaccine application is generated by delivery of sufficient amounts antigen skin and administration toxin adjuvants or invasive abrasion that leads an adjuvant effect. Microneedles penetrate the stratum corneum, outermost layer skin, enable direct vaccines from surface into where immunocompetent dendritic cells are densely distributed. However, whether microneedles activates antigen-presenting (APCs) has not been demonstrated. Here we aimed...
The safety and pharmacokinetics of single multiple doses a novel mGlu2/3 receptor agonist prodrug, MGS0274 besylate (TS-134), were investigated in healthy subjects.Phase 1 single-ascending dose (5-20 mg) multiple-ascending titration (5-80 studies conducted male female subjects. Both randomized, double-blinded placebo-controlled. In one cohort study (10 mg), concentrations MGS0008, the active compound, cerebrospinal fluid (CSF) measured for up to 24 hours postdose.Following oral...
50代，男性．数日前からの血尿にて受診し，著明な血小板減少，LDH高値，腎障害を認め，即日入院．血栓性血小板減少性紫斑病（thrombotic thrombocytopenic purpura：TTP）と考え，ステロイド薬投与，血漿交換を開始したが，第3病日に全身性痙攣，意識障害を来たし，人工呼吸器管理となった．連日血漿交換を行ったが状態改善せず，ADAMTS13活性感度以下，インヒビター高力価が判明し，第7病日からrituximabの投与を行った．連日の血漿交換施行下でようやく血小板増加，病状改善を得られ，以後，長期的に寛解を維持している．