A5066240613- Glutathione Transferases and Polymorphisms
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Genomics, phytochemicals, and oxidative stress
- Nutritional Studies and Diet
- Ocular Diseases and Behçet’s Syndrome
- Pregnancy and Medication Impact
- Selenium in Biological Systems
- Health, Environment, Cognitive Aging
- Autopsy Techniques and Outcomes
- Glaucoma and retinal disorders
- Inflammasome and immune disorders
- Diabetes Treatment and Management
- Radiation Effects and Dosimetry
- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- Heavy Metal Exposure and Toxicity
- Cancer Risks and Factors
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
Zayed Military Hospital
2024
Jamia Hamdard
2024
Department of Biotechnology
2024
Islamia University of Bahawalpur
2024
Riyadh Armed Forces Hospital
2016-2023
Liaquat National Hospital
2023
Rawalpindi Medical University
2022
Hamad Medical Corporation
2022
University of Jeddah
2022
University of Sharjah
2022
Alzheimer’s disease (AD) could result from a multifactorial process involving both genetic predisposition and exposure to environmental factors like pesticides. A case control study of 70 patients AD 75 controls was done examine the association between organochlorine pesticides (OCPs) risk AD. OCPs (hexachlorocyclohexane (HCH), aldrin, dieldrin, endosulfan, pp′-dichlorodiphenyldichloroethylene ( pp′-DDE), op′-DDE, pp′-dichlorodiphenyltrichloroethane pp′-DDT), op′-DDT,...
The present study was performed to examine the effect of Eugenia caryophyllata (Myrtaceae) on learning and memory, also evaluate whether it can modulate oxidative stress in mice. Passive avoidance step-down task elevated plus-maze were used assess memory scopolamine-treated Oxidative parameters assessed brain samples by estimating malondialdehyde (MDA) reduced glutathione (GSH) levels at end study. Scopolamine (0.3 mg/kg, i. p.) produced impairment acquisition as evidenced a decrease latency...
SUMMARY The T cell response to antigens from Leishmania major promastigotes was investigated in peripheral blood mononuclear cells Sudanese individuals with a history of cutaneous leishmaniasis (CL), positive DTH reaction the leishmanin skin test but no lesions, and Danes without known exposure parasites. Proliferation production interferon-gamma (IFN-γ) IL-4 antigen-stimulated cultures measured. Lymphocytes CL proliferated vigorously produced IFN-γ after stimulation either crude preparation...
Abstract Nephrotoxicity of organochlorine pesticides (OCPs) has been established in experimental animal models. This study was designed to evaluate the relationship blood OCPs level with estimated glomerular filtration rate (eGFR) and oxidative stress (OS) chronic kidney disease (CKD) patients. Patients different stages CKD ( n = 150) age, sex matched healthy controls 96) were recruited. The analyzed by gas chromatography, plasma levels several OS parameters such as malondialdehyde (MDA),...
We investigated the association between glutathione S-transferases mu1 (GSTM1), theta 1 (GSTT1), Cytochrome P450IA1-T6235C (rs4646903, CYP1A1m1) and CYP1A1-1462V (rs1048943, CYP1A1m2) gene polymorphisms, organochlorine pesticides (OCPs) level with risk of preterm delivery (PTD). Maternal cord blood samples PTD (n = 156) cases subjects full-term (FTD, n 151) were collected at time delivery/after delivery. Women occupationally exposed to OCPs other high-risk factors such as anemia,...
Herpes Zoster is a viral infection that occurs due to reactivation of the Varicella virus. A vaccine has been approved for adults aged 50 and above prevention its complications. This study aims assess at-risk population's awareness disease vaccine, attitudes practices toward vaccine. quantitative, observational, cross-sectional was conducted among 420 age 50. Non-probability, convenience sampling used select participants from public venues. SPSS-25 analyze data. 64.3% (n = 270) heard Zoster....
The cause of Parkinson's disease (PD) remains elusive, but environmental chemical exposures have been postulated to be involved in the etiology PD. We examined association between persistent organochlorine pesticides (OCPs) and PD North Indian population. This case control study included 70 75 subjects age group 50 85 years. Blood samples were collected high-purity grade hexane acetone (2 : 1 ratio) used for extraction residues. OCPs (hexachlorocyclohexane (HCH), aldrin, dieldrin,...
Background: Type 2 Diabetes develops in adulthood, and is caused due to failure of pancreatic B-cells secrete insulin, gradually causing desensitization glucose, leading insulin resistance1-5. According American Association, the chronicity this disease, long-term complications arise which mostly occur hyperglycemia microvascular macrovascular damage6. This brings about significant damage heart, eyes(retinopathy), kidneys (chronic kidney disease) nerves(neuropathy).5 Metabolic...
Objectives: The aim was to examine the gene environment (GxE) interaction with reference APO E genotypes, serum lipids and organochlorine pesticides (OCPs) as one of factors in etiology Alzheimer’s disease (AD). Methods: A case control study used examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)/PCRrestriction fragment length method, autoanalyser OCPs gas chromatography (GC). Results: ∊4 allele frequency significantly high (p=0.000, OR=5.73, CI=2.68-12.50) AD compared...
Objective To evaluate salivary progesterone as a predictor of early preterm birth ( PTB ) and compare it with transvaginal sonographic TVS cervical length in asymptomatic high‐risk women. Design Prospective study. Setting Departments O bstetrics G ynaecology B iochemistry at UCMS & GTBH , D elhi, I ndia. Sample Ninety pregnant Methods The concentration saliva women high risk for delivery was estimated by immunoassay, measured the first antenatal visit 24–28 weeks gestation, then repeated...
Association of glutathione S-transferase (GST) M1 and T1 deletions with benign prostate hyperplasia (BPH) cancer is well reported. These enzymes metabolize numerous toxins thus protecting from oxidative injury. Oxidative stress has been associated development BPH cancer. The present study was designed to analyze role GST in these subjects. GSTs are responsible for metabolism tobacco therefore effect usage groups also studied. Three subjects: (57 patients), (53 patients) controls (46...
Hypertension, a chronic medical condition of increased blood pressure, is serious public health problem. Environmental and genetic risk factors are known to predispose hypertension. The present study was designed investigate the association glutathione S-transferase (GST) gene polymorphism with oxidative stress in hypertensive patients possible beneficial effect yoga on them.Sixty (60) individuals, between 30 60 years age, were divided into two groups each. group subjected 50-60 minutes...